...Robert A. Clayton; Jane E. Nally; Neil C. Thomson; John C. McGrath 1. The aim of this study was to compare the ability of four different bronchodilators (atrial natriuretic peptide, salbutamol, sodium nitroprusside and isosorbide dinitrate) to reverse and also to protect against contractions evoked...

... for measuring nasal potential difference, a pilot study was carried out using topical amiloride, a drug which has previously been shown to inhibit airway epithelium sodium transport in vivo. We then studied the effects of ouabain and digoxin, two inhibitors of Na + -K + -ATPase, and salbutamol, a drug which...

... male subjects received single oral doses of BRL 35135 (8 mg) or the selective β 2 -adrenoceptor agonist salbutamol (8 mg) after pretreatment with placebo, bisoprolol (5 mg) as a selective β 1 -antagonist or nadolol (20 mg) to block β 1 -and β 2 -, but not β 3 -adrenoceptors. 3. BRL 35135 and salbutamol...

... study, we investigated the effects of a slow-release preparation of salbutamol or a placebo on skeletal muscle functional capacity in 12 healthy men. The strength of different muscle groups was measured on two occasions before and after 14 and 21 days of treatment. 2. No significant changes in muscle...

... of potassium plus 24 mmol of magnesium; (f) 5 mg of bendrofluazide plus 50 mg of triamterene. 2. After each treatment period, subjects were given two doses of inhaled salbutamol (each of 1 mg), and measurements were made 25 min after each dose. 3. Treatment with bendrofluazide plus salbutamol produced a lower...

... and insulin-induced hypoglycaemia stress tests. 2. The effects of l -adrenaline infusions, sufficient to achieve pathophysiological levels of adrenaline, and of therapeutic intravenous infusions of salbutamol, a β 2 -agonist, on plasma magnesium, plasma potassium, plasma glucose and plasma insulin levels were...

...Stanley Braude; David Royston 1. The effect in the rat of salbutamol infusion (1 μg min −1 kg −1 ) on acid-induced lung injury has been determined. Severity of lung injury was assessed by two techniques: the pulmonary clearance of 99m Tc-diethylenetriaminepenta-acetate ( 99m Tc-DTPA) and the lung...

... was seen in the number of α 1 -receptors in normoxia and in chronic hypoxia [ B max .: normoxic control 48 ( sem 3), hypoxic 48 ( sem 5) fmol/mg of protein]. 6. Treatment with salbutamol (2.5 mg/kg twice daily subcutaneously) did not reduce the number of β-adrenceptors in lung either during normoxia...

...C. M. B. Higgs; R. B. Richardson; G. Laszlo 1. Airway responses to inhaled salbutamol were measured in two groups of six normal non-atopic subjects. In each group there was a dose-dependent increase in specific airways conductance after salbutamol inhaled in cumulative doses from 25 to 600 μg. 2...

...W. MacNee; N. J. Douglas; M. F. Sudlow 1. Bronchodilatation was produced in eight normal subjects by inhalation, on separate occasions, of the atropine-like drug ipratropium bromide (0·16 mg by pressurized inhaler; 1 mg nebulized) and the β-sympathomimetic salbutamol (0·8 mg by pressurized inhaler...

...J. E. Harvey; C. J. Baldwin; P. J. Wood; K. G. M. M. Alberti; A. E. Tattersfield 1. Airway, metabolic and cyclic nucleotide responses to intravenous salbutamol were measured in five patients with mild asthma who had taken no medication in the week before the study. The studies were repeated after...

...S. T. Holgate; W. A. Stubbs; P. J. Wood; E. S. McCaughey; K. G. M. M. Alberti; A. E. Tattersfield 1. The airway and metabolic responses to an intravenous β 2 -agonist salbutamol have been investigated in normal subjects before and after chronic administration of inhaled salbutamol, 1600 μg daily...