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1-22 of 22
Keywords: saralasin
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (5): 517–524.
Published: 01 May 1984
...C. J. Mathias; R. J. Unwin; F. A. Pike; H. L. Frankel; P. S. Sever; W. S. Peart 1. The cardiovascular and hormonal effects of intravenous saralasin (0.5, 1 and 5 μg min −1 kg −1 ) were assessed in nine tetraplegic patients (with complete cervical spinal cord transaction above the sympathetic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 65 (3): 255–261.
Published: 01 September 1983
...-treated rats, though both catecholamines tended to be higher after administration of the PNMT inhibitor. 4. In two additional groups of glucocorticoid-hypertensive rats, the blood pressure effects of an infusion of saralasin, a competitive antagonist of angiotensin II, or of a bolus injection...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 153s–156s.
Published: 01 October 1982
... and plasma and aortic renin concentrations were determined at 1, 3, 6 or 9 h after injection. In separate groups of rats the effect of the competitive angiotensin II antagonist, saralasin, on blood pressure was measured 3 or 6 h after renin injection. 2. Blood pressure remained elevated for up to 6 h after...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 343s–345s.
Published: 01 October 1982
... produced significant increases in cerebrospinal fluid and plasma noradrenaline. Intravertebral artery infusion of [Sar 1 , Ala 8 ]angiotensin II (saralasin) significantly suppressed the frusemide-induced increases in cerebrospinal and plasma noradrenaline and resulted in a fall in arterial blood pressure...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (6): 573–579.
Published: 01 June 1982
..., we infused the angiotensin II competitive blocker, saralasin, into GH rats under sodium pentobarbital anaesthesia and examined renal haemodynamics and excretory function of each kidney before and during saralasin infusion and after cessation of saralasin infusion. 2. Saralasin reduced mean arterial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (2): 175–180.
Published: 01 August 1981
...Hiromichi Suzuki; Kazuoki Kondo; Michiko Handa; Takao Saruta 1. To examine the possible participation of the brain iso-renin-angiotensin system in the control of blood pressure, as well as in the regulation of plasma renin activity, saralasin and captopril were injected into the cerebral ventricles...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 75s–78s.
Published: 01 December 1980
...R. Fagard; A. Amery; P. Lijnen 1. To study which factors determine the balance between the antagonistic and agonistic effects of the angiotensin II analogue [Sar 1 ,Ala 8 ]-angiotensin II (saralasin) in man, saralasin was infused in subjects on a ‘normal’ sodium intake (group 1) during sodium...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 79s–82s.
Published: 01 December 1980
... min. 4. Saralasin or captopril also lowered blood pressure of spontaneously hypertensive rats, but progressively over a period of 3 h. 5. The results suggest that dopamine and angiotensin have opposite effects on the neurosecretion of vasopressin. 6. Vasopressin appears to be involved in maintenance...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 175s–178s.
Published: 01 December 1980
... of the dipeptidyl carboxypeptidase inhibitor captopril (250 μg) during continuous saralasin-induced angiotensin II blockade (10 μg/min). Dietary sodium restriction alone in sham-operated rats had no effect. 2. Acute bilateral adrenalectomy (18-24 h) did not preclude the demonstration of an augmented response...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 58 (1): 15–20.
Published: 01 January 1980
... of the angiotensin II antagonist saralasin was quite ineffective. The difference in response to the two inhibitors may have been due to bradykinin potentiation by the converting enzyme inhibitor. 4. Although plasma renin is often elevated in Goldblatt two-kidney rats with hypertension of more than 4 months' duration...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 313s–316s.
Published: 01 December 1979
...D. B. Case; S. A. Atlas; J. H. Laragh 1. Saralasin and converting enzyme inhibitors SQ 20881 and captopril induced increases in plasma renin activity to greater than 14 ng h −1 ml −1 in 43 out of 44 patients with untreated renovascular hypertension when studied in the seated position and on normal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 119s–121s.
Published: 01 December 1979
...S. N. Hunyor; H. Larkin; Janet Rowe 1. The haemodynamic response to antagonistic (10 μg min −1 kg −1 ) and agonistic (40 μg min −1 kg −1 ) doses of saralasin was studied in young essential hypertensive patients. Blood pressure behaviour alone was thought to be inadequate to describe the response...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 131s–134s.
Published: 01 December 1979
... by 27·1 mmHg ( n = 18) with no further change of plasma ANG II. δMBAP was significantly related to control log plasma renin (PRA) and log ANG II in both conditions. 2. The acute depressor response to captopril was 11·2 mmHg greater ( P < 0·001) than δMBAP during saralasin infusion ( n = 12). 3. Heart...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 145s–148s.
Published: 01 December 1979
...G. A. MacGregor; N. D. Markandu; J. E. Roulston 1. Propranolol, saralasin and captopril changed blood pressure in normotensive as well as hypertensive subjects. 2. The percentage change in blood pressure with these three drugs for a given plasma renin activity was similar in normotensive...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 307s–309s.
Published: 01 December 1978
...G. Leonetti; Laura Terzoli; Carla Sala; C. Bianchini; Laura Sernesi; A. Zanchetti 1. The pressor role of renin stimulated by chronic diuretic therapy has been assessed in 31 patients with essential hypertension by infusing the angiotensin II antagonist, saralasin, immediately before and at the end...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 319s–321s.
Published: 01 December 1978
... angiotensin II concentration did not differ markedly from reference values in 25 40-year-old control subjects. In the untreated, sodium replete state saralasin infusion (5·4 nmol min −1 kg −1 ) produced an increase in mean arterial pressure in the patient group as a whole. 3. Twenty-one patients were treated...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 243s–246s.
Published: 01 December 1978
...Chang-Seng Liang; Haralambos Gavras; H. R. Brunner 1. Salt depletion was produced in five dogs by a low salt diet and daily administration of frusemide for 5 days; a control group of five dogs was placed on the same diet, to which 2·5 g of sodium chloride was added. 2. Saralasin infusion (0·5 μg...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 297s–299s.
Published: 01 December 1978
...M. H. Maxwell; P. Varady; E. T. Zawada; J.-F. Burkhalter; U. Waks; L. Marks 1. Thirty-four patients with essential hypertension and 37 with proven renovascular hypertension were tested with saralasin after frusemide-induced diuresis. 2. Variables used for analysis were: pre-saralasin plasma renin...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 301s–303s.
Published: 01 December 1978
...S. F. Wong; M. I. Mitchell; V. Robson; R. Wilkinson 1. Plasma renin activity, response to saralasin and exchangeable sodium have been measured in 43 patients with early renal disease. 2. Blood pressure was directly proportional to plasma renin activity. However, mean plasma renin activity was lower...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (3): 305–312.
Published: 01 March 1978
... correlated with plasma renin activity and the correlation was not improved when blood pressure was related to expressions combining renin and volume. 2. Changes in supine mean blood pressure during saralasin infusion were related to pre-infusion plasma renin activity ( P < 0·001) or plasma angiotensin II...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (4): 341–348.
Published: 01 October 1977
...B. P. McGrath; J. G. G. Ledingham; C. R. Benedict 1. The initial blood pressure response to saralasin (Sar 1 -Ala 8 -angiotensin II) infusion was examined in 15 normal subjects, eight patients with untreated essential hypertension and 65 patients established on chronic haemodialysis (including six...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (s3): 193s–196s.
Published: 01 December 1976
...G. A. MacGregor; P. M. Dawes 1. Saralasin (Sar 1 -Ala 8 -angiotensin II), a competitive inhibitor of angiotensin II (AII), has been infused into normal subjects and patients with essential hypertension when deprived of sodium by 5 days of a 10 mmol/day sodium diet. 2. When saralasin was given...