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Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1207–1223.
Published: 11 November 2015
... disrupts Plic-1 binding to GABA A Rs, significantly shortened the latency of seizure onset, and increased the seizure severity and duration in these two epileptic models. Overexpressed Plic-1 through lentivirus transfection into a PTZ model resulted in a reduction in both seizure severity and generalized...