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Keyword: sepsis
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Articles
Clin Sci (Lond) (2019) 133 (18): 1993–2004.
Published: 24 September 2019
... Ritter; Felipe Dal-Pizzol Background: Several different mechanisms have been proposed to explain long-term cognitive impairment in sepsis survivors. The role of persisting mitochondrial dysfunction is not known. We thus sought to determine whether stimulation of mitochondrial dynamics improves...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... Portland Press Limited on behalf of the Biochemical Society 2018 acute kidney injury endothelin-1 fibroblast mTORC1 sepsis TSC1 Sepsis, a dysregulated host response to severe infection [ 1 ], has been shown to occur in 32.4–47.5% of critically ill patients with acute kidney injury (AKI...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (13): 1433–1438.
Published: 18 July 2018
...Amel Komic; Patricia Martinez-Quinones; Cameron G. McCarthy; R. Clinton Webb; Camilla F. Wenceslau Sepsis is a profoundly morbid and life-threatening condition, and an increasingly alarming burden on modern healthcare economies. Patients with septic shock exhibit persistent hypotension despite...
Articles
Clin Sci (Lond) (2017) 131 (8): 747–758.
Published: 06 April 2017
...Jerome Morel; Iain Hargreaves; David Brealey; Viruna Neergheen; Janne T. Backman; Sandro Lindig; Marcus Bläss; Michael Bauer; Daniel F. McAuley; Mervyn Singer Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated the...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (4): 259–271.
Published: 14 January 2016
...Veronica I. Landoni; Daiana Martire-Greco; Nahuel Rodriguez-Rodrigues; Paula Chiarella; Pablo Schierloh; Martin A. Isturiz; Gabriela C. Fernández Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis. Repetitive inoculation of increasing doses...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... hypometabolic phenotype triggered by glucocorticoid-induced mitochondrial dysfunction activating the NLRP1 inflammasome prevents normal lymphocyte functionality and increases apoptosis. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis • The mechanism underlying a potential...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (1): 49–61.
Published: 01 April 2015
...Ting He; Jiongyu Hu; Guangning Yan; Lingfei Li; Dongxia Zhang; Qiong Zhang; Bing Chen; Yuesheng Huang The integrity of the vascular barrier, which is essential to blood vessel homoeostasis, can be disrupted by a variety of soluble permeability factors during sepsis. Pigment epithelium-derived...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
...Yvette C. Luiking; Martijn Poeze; Nicolaas E. Deutz Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (12): 857–867.
Published: 05 March 2014
... sepsis. The target genes were predicted by bioinformatics analysis; the levels of the respective proteins in the sera of patients with sepsis were detected by ELISA. ACVR2A (activin A receptor, type IIA), FOXO1 (forkhead box O1), IHH (Indian hedgehog), STK4 (serine/threonine kinase 4) and DUSP3 (dual...
Articles
Clin Sci (Lond) (2014) 126 (5): 355–365.
Published: 01 November 2013
...Daiana Martire-Greco; Veronica I. Landoni; Paula Chiarella; Nahuel Rodriguez-Rodrigues; Pablo Schierloh; Barbara Rearte; Martin A. Isturiz; Gabriela C. Fernandez Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis. Strategies aimed at...
Articles
Clin Sci (Lond) (2013) 125 (3): 131–141.
Published: 12 April 2013
...: Dr Chin-Wei Chiao (email chinwei.chiao@msa.hinet.net ). 5 9 2012 16 1 2013 7 3 2013 7 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cyclo-oxygenase interleukin-1β lipopolysaccharide nitric oxide synthase P2X 7 receptor sepsis tumour...
Articles
Clin Sci (Lond) (2013) 125 (2): 77–85.
Published: 26 March 2013
...Hadj Ahmed Mostefai; Jean-Michel Bourget; Ferhat Meziani; Maria Carmen Martinez; Daniela Leonetti; Alain Mercat; Pierre Asfar; Lucie Germain; Ramaroson Andriantsitohaina During sepsis, inflammation can be orchestrated by the interaction between circulating and vascular cells that, under activation...
Articles
Clin Sci (Lond) (2013) 124 (6): 389–390.
Published: 27 November 2012
... cycling in cardiac tissue of rats with early sepsis could discriminate survivors from non-survivors. These findings underscore the great potential of systems biology in translational medicine. However, further investigations should be done to make the benchside results more feasible for routine clinical...
Articles
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
...Alain Rudiger; Alex Dyson; Karen Felsmann; Jane E. Carré; Valerie Taylor; Sian Hughes; Innes Clatworthy; Alessandro Protti; Denis Pellerin; Jana Lemm; Ralf A. Claus; Michael Bauer; Mervyn Singer Myocardial function is depressed in sepsis and is an important prognosticator in the human condition...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (3): 173–192.
Published: 12 April 2012
... antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia and...
Articles
Clin Sci (Lond) (2012) 122 (3): 133–142.
Published: 11 October 2011
..., we investigated whether muscle protein degradation is increased in critically ill patients with sepsis and which proteolytic enzyme systems are involved in this degradation. Eight patients and seven healthy volunteers were studied. In vivo muscle protein kinetics was measured using arteriovenous...
Articles
Clin Sci (Lond) (2010) 118 (6): 421–427.
Published: 14 December 2009
...Rokhsareh F. Vesali; Norbert Cibicek; Towe Jakobsson; Maria Klaude; Jan Wernerman; Olav Rooyackers The human endotoxin model has been used to study the early phase of sepsis. The aim of the present study was to assess leg muscle protein kinetics after an endotoxin challenge given to healthy human...
Articles
Clin Sci (Lond) (2009) 117 (9): 313–319.
Published: 01 September 2009
... glutathione status and glutathione kinetics in healthy volunteers during the initial phase of sepsis using a human endotoxin model. The present study was a descriptive pilot study in healthy male volunteers ( n =8) before and after an endotoxin challenge. The glutathione status was determined in plasma and...
Articles
Clin Sci (Lond) (2009) 116 (9): 721–730.
Published: 02 April 2009
...Visith Thongboonkerd; Wararat Chiangjong; Jan Mares; Jiri Moravec; Zdenek Tuma; Thomas Karvunidis; Supachok Sinchaikul; Shui-Tein Chen; Karel Opatrný, Jr; Martin Matejovic Sepsis is a systemic response to infection commonly found in critically ill patients and is associated with multi-organ failure...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2008) 115 (11): 343–351.
Published: 03 November 2008
... studies have demonstrated the immunomodulatory effects of quorum-sensing signal molecules. In the present study, we have examined the impact of these molecules on normal human immune function in vitro and compared this with immune changes in patients with sepsis where quorum-sensing signal molecules were...
Articles
Clin Sci (Lond) (2008) 114 (2): 123–130.
Published: 11 December 2007
... compilation © 2008 Biochemical Society 2008 albumin capillary leak fluorophore poly(ethylene glycol) redistribution phase sepsis vascular permeability Attaching PEG [poly(ethylene glycol)] to proteins (PEGylation) increases their intravascular retention time [ t ½ (half-life)] by...
Articles
Clin Sci (Lond) (2007) 112 (9): 499–506.
Published: 02 April 2007
...Maria Klaude; Katarina Fredriksson; Inga Tjäder; Folke Hammarqvist; Bo Ahlman; Olav Rooyackers; Jan Wernerman Patients with sepsis in the ICU (intensive care unit) are characterized by skeletal muscle wasting. This leads to muscle dysfunction that also influences the respiratory capacity, resulting...
Articles
Clin Sci (Lond) (2002) 102 (6): 645–650.
Published: 14 May 2002
...Michael C. READE; Megan F. CLARK; J. Duncan YOUNG; C.A.R. BOYD Increased production of nitric oxide (NO) is thought to be a factor in the pathogenesis of many human diseases - among them the hypotension that often accompanies sepsis. The supply of the cationic amino acid arginine is known to be...
Articles
Clin Sci (Lond) (2001) 101 (3): 295–304.
Published: 15 August 2001
...Michael J. O'LEARY; Colin N. FERGUSON; Michael J. RENNIE; Charles J. HINDS; John H. COAKLEY; Victor R. PREEDY We have investigated sequential changes in skeletal muscle and hepatic protein synthesis following sepsis, and their relationship to changes in circulating and tissue glutamine...
Articles
Clin Sci (Lond) (2001) 100 (2): 169–182.
Published: 02 January 2001
... concept that iron (often viewed as the ‘villain’ in free radical biology) can also be considered as a signalling species. Iron is intimately involved in the regulation of its own storage, compartmentalization and turnover. During adult respiratory distress syndrome (ARDS) and sepsis, such regulation may...
Articles
Clin Sci (Lond) (2001) 100 (1): 81–89.
Published: 08 December 2000
...Suveer SINGH; Peter B. ANNING; C. Peter WINLOVE; Timothy W. EVANS Sepsis is characterized by increased microvascular permeability and regional variations in capillary perfusion, which may be modulated by nitric oxide (NO) and reversed by fluid resuscitation (FR). The effects of saline FR and NO...
Articles
Clin Sci (Lond) (2000) 99 (6): 489–496.
Published: 07 November 2000
...Quan WANG; Xiaoyan SUN; Timothy A. PRITTS; Hector R. WONG; Per-Olof HASSELGREN Previous studies suggest that production of interleukin-6 (IL-6) is increased in the intestinal mucosa during sepsis and endotoxaemia. We tested the hypothesis that mucosal IL-6 production during endotoxaemia is...
Articles
Clin Sci (Lond) (2000) 99 (4): 321–328.
Published: 05 September 2000
...Cécile CHAMBRIER; Martine LAVILLE; Khalid RHZIOUAL BERRADA; Michelle ODEON; Paul BOULÉTREAU; Michel BEYLOT In order to quantify the changes in insulin sensitivity, particularly of endogenous glucose production and fat metabolism, in patients with severe sepsis, a prospective study was conducted in...
Articles
Clin Sci (Lond) (2000) 98 (2): 193–200.
Published: 11 January 2000
... increase in blood pressure as observed in matched sheep of the l -NMMA group (non-septic phase). Treatment was discontinued after 3 h. Sepsis was initiated and maintained by a continuous infusion of live Pseudomonas aeruginosa . After 24 h of sepsis, the sheep were again challenged over a treatment period...
Articles
Clin Sci (Lond) (1999) 97 (5): 529–538.
Published: 15 September 1999
... monocytes, and higher concentrations of IL-6, IL-8 and sIL-2R. C-reactive protein and soluble E-selectin concentrations did not differ between groups. No parameter alone identified all patients that subsequently developed OF. However, a sepsis-related inflammation severity score (SISS), developed on the...
Articles
Clin Sci (Lond) (1998) 95 (4): 467–478.
Published: 01 October 1998
... injury normally found during sepsis in our porcine model. 8. These findings suggest that during sepsis a protective endogenous β 2 adrenergic receptor-mediated anti-inflammatory response is activated via cell membrane transduction to stimulate the trimeric G-protein complex Gs and activate the second...
Articles
Clin Sci (Lond) (1997) 92 (5): 519–525.
Published: 01 May 1997
...Tory A. Meyer; Jing Jing Wang; Gregory M. Tiao; Cora K. Ogle; Josef E. Fischer; Per-Olof Hasselgren 1. In previous studies, experimental endotoxaemia was found to stimulate cytokine production in the central nervous system. The effect of sepsis on brain cytokines is not fully known. We compared the...
Articles
Clin Sci (Lond) (1996) 91 (3): 371–374.
Published: 01 September 1996
.... 30 4 1996 7 5 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 lipid neutrophils sepsis total parenteral nutrition Clinical Science (1996) 91, 371-374 (Printed in Great Britain) 37 I Neutrophil adhesion molecule expression and response to stimulation...
Articles
Clin Sci (Lond) (1996) 90 (3): 173–182.
Published: 01 March 1996
...Mark Sair; C. Peter Winlove; Timothy W. Evans © 1996 The Biochemical Society and the Medical Research Society 1996 microcirculationn sepsis tissue nutrition tissue oxygenation tissue perfusion Clinical Science (1996) 90. 173-182 (Printed in Great Britain) Editorial Review I73...
Articles
Clin Sci (Lond) (1995) 89 (6): 601–609.
Published: 01 December 1995
...Ceri J. Green; I. T. Campbell; Ellen O'sullivan; S. Underhill; D. P. M. McLaren; L. J. Hipkin; I. A. MacDonald; Jean Russell 1. Patients suffering trauma and sepsis are insulin resistant, but no studies have specifically been made of patients suffering multiple organ failure. 2. We have studied...
Articles
Clin Sci (Lond) (1995) 89 (3): 311–319.
Published: 01 September 1995
...Takashi Higashiguchi; Yoshifumi Noguchi; Tory Meyer; Josef E. Fischer; Per-Olof Hasselgren 1. We studied the effect of sepsis and the regulation by glutamine of protein synthesis in enterocytes isolated from the small intestine of rats. 2. Sepsis was induced by caecal ligation and puncture; control...
Articles
Clin Sci (Lond) (1995) 88 (5): 587–594.
Published: 01 May 1995
...Bart J. Biemond; Marcel Levi; Hugo Ten Cate; Tom Van Der Poll; Harry R. Büller; C. Erik Hack; Jan W. Ten Cate 1. Disseminated intravascular coagulation frequently accompanies Gram-negative sepsis and may contribute to widespread deposition of microthrombi. Besides the endotoxin-induced activation...
Articles
Clin Sci (Lond) (1995) 88 (4): 393–400.
Published: 01 April 1995
...Jon S. Friedland © 1995 The Biochemical Society and the Medical Research Society 1995 65-kDa heat shock protein Interleukin 8 malaria monocyte chemotactic protein 1 sepsis toxoplasmosis tuberculosis Clinical Science (1995) 88, 393-400 (Printed in Great Britain) 393 Glaxo/MRS Young...
Articles
Clin Sci (Lond) (1994) 87 (5): 539–546.
Published: 01 November 1994
...D. C. Macallan; G. E. Griffin 1. Sepsis is associated with marked changes in cardiac muscle protein synthesis. Such changes may be the result of altered transcription of specific myofibrillar protein mRNAs. 2. In order to investigate myofibrillar protein gene expression, a rat model of sepsis was...
Articles
Clin Sci (Lond) (1994) 87 (2): 207–211.
Published: 01 August 1994
...Takashi Higashiguchi; Yoshifumi Noguchi; William O'Brien; Kenneth Wagner; Josef E. Fischer; Per-Olof Hasselgren 1. In a previous study we found that the protein synthesis rate was increased by 50–60% in the mucosa of the jejunum and ileum during sepsis in rats. It is not known if sepsis affects...
Articles
Clin Sci (Lond) (1994) 86 (4): 359–374.
Published: 01 April 1994
...Nicholas P. Curzen; Mark J. D. Griffiths; Timothy W. Evans © 1994 The Biochemical Society and the Medical Research Society 1994 endothelin endothelium nitric oxide sepsis vasculature Clinical Science (1994) 86, 359-374 (Printed in Great Britain) Editorial Review 359 Role of the...
Articles
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Articles
Clin Sci (Lond) (1992) 83 (4): 495–501.
Published: 01 October 1992
...-esterified fatty acids secondary to hepatic vasoconstriction. 16 6 1992 19 6 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 ketone bodies lipolysis platelet-activating factor sepsis Clinical Science (1992) 83, 495-501 (Printed in Great Britain) PI atele...
Articles
Clin Sci (Lond) (1992) 82 (6): 709–716.
Published: 01 June 1992
...M. Salleh; M. Ardawi 1. The hepatic metabolism of glutamine, alanine, ammonia, urea, glutathione and glucose was studied in rats made septic by caecal ligation and puncture and was compared with that in rats that had undergone sham operation (laparotomy). 2. Sepsis resulted in increases in the...
Articles
Clin Sci (Lond) (1992) 82 (5): 573–580.
Published: 01 May 1992
... with or without epidermal growth factor treatment survived sepsis significantly better than other septic rats given parenteral nutrition. The cumulative percentage of deaths over 4 days in septic rats infused with glutamine-supplemented parenteral nutrition was 20% (without epidermal growth factor) and...
Articles
Clin Sci (Lond) (1992) 82 (4): 419–427.
Published: 01 April 1992
...M. Salleh; M. Ardawi 1. The effects of parenteral nutrition with or without xylitol and/or glutamine supplementation were studied in septic rats after 4 days of treatment. 2. Septic rats treated with xylitol- and/or glutamine-supplemented parenteral nutrition survived sepsis significantly better...
Articles
Clin Sci (Lond) (1992) 82 (2): 205–209.
Published: 01 February 1992
.... Parallel changes occurred in hepatic ketone bodies. 3. It is concluded that tumour necrosis factor-α and interleukin-1-α are not responsible for the hypoketonaemia associated with sepsis or other inflammatory states. 13 8 1991 30 8 1991 © 1992 The Biochemical Society and the Medical...
Articles
Clin Sci (Lond) (1991) 81 (6): 815–822.
Published: 01 December 1991
... sepsis sheep Clinical Science (1991) 81,815-822 815 Superoxide production by peripheral blood monocytes during sustained endotoxaemia in sheep BARBARA S. POLLA*, JOSIANE CLERC*, JEAN-FRANCOIS PITTEV AND DENIS R. MOREL? *Allergy Unit, Department of Medicine, University Hospital of Geneva, Geneva...
Articles
Clin Sci (Lond) (1991) 81 (5): 603–609.
Published: 01 November 1991
... concentrations were markedly increased as compared with sham-operated rats. Conversely, blood ketone body and plasma cholesterol concentrations were significantly decreased in septic rats. Both plasma insulin and plasma glucagon concentrations were markedly elevated in response to sepsis. Sepsis resulted in a...
Articles
Clin Sci (Lond) (1991) 81 (3): 357–365.
Published: 01 September 1991
... Society and the Medical Research Society 1991 endothelin endotoxin pulmonary lymph sepsis septic shock Clinical Science (1991) 81,357-365 357 Time course of plasma and pulmonary lymph endothelin-like immunoreactivity during sustained endotoxaemia in chronically instrumented sheep D. R. MOREL...