...Olivier Huet; Jaye P. F. Chin-Dusting Septic shock results from the dysregulation of the innate immune response following infection. Despite major advances in fundamental and clinical research, patients diagnosed with septic shock still have a poor prognostic outcome, with a mortality rate of up...

.... 2004 42 440 449 adrenocorticotropic hormone (ACTH) aminoprocalcitonin peptide (N-PCT) cytokine mortality procalcitonin septic shock Sepsis and the closely related condition SIRS (systemic inflammatory syndrome) yearly affects 18 million people throughout the world [ 1...

...Eva Tavares; Francisco J. Miñano Severe sepsis and septic shock are an important cause of mortality and morbidity. These illnesses can be triggered by the bacterial endotoxin LPS (lipopolysaccharide) and pro-inflammatory cytokines, particularly TNF-α (tumour necrosis factor-α) and IL (interleukin...

... in patients with sepsis or septic shock and in healthy volunteers. Endogenous leucine flux, an index of whole-body protein breakdown rate, was measured in 13 critically ill patients with sepsis or septic shock and seven healthy controls using an intravenous infusion of [1- 13 C]leucine. Arginine flux...

... 77555-0833, U.S.A. (e-mail dltraber@utmb.edu ). 26 9 2002 25 10 2002 3 1 2003 The Biochemical Society and the Medical Research Society © 2003 2003 anticoagulant haemodynamics infection/inflammation Pseudomonas aeruginosa septic shock thrombosis 349Clinical Science...

... to be rate-limiting for NO production. We hypothesized that cationic amino acid transport might be increased in cells producing excess NO from patients with septic shock. Peripheral blood mononuclear cells were isolated from patients with sepsis and from healthy control subjects. The rates of both...

...Olivier APPOLONI; Jean-Louis VINCENT; Jean DUCHATEAU We hypothesized that cytokine production following delayed in vitro cell stimulation (to reproduce physiological cellular status at baseline) may be related to outcome in patients with septic shock. A total of 20 patients were included...

... The Biochemical Society and the Medical Research Society © 2002 2002 inflammation lipopolysaccharides nitric oxide septic shock vascular smooth muscle. 297Clinical Science (2002) 102, 297 305 (Printed in Great Britain) The role of inducible nitric oxide synthase in lipopolysaccharide-mediated...

... and monocyte counts, and high concentrations of IL-6, IL-8 and sIL-2R predict OF in patients with community-acquired septic shock, and the combination of these markers may provide the means to identify sepsis patients who will develop OF. Correspondence : Dr Annika Takala (e-mail annika.takala...

... Research Society 1995 nitric oxide nitric oxide synthase septic shock septicaemia shock Clinical Science (1995) 88, 131-133 (Printed i n Great Britain) Rapid Communication 131 Nitric oxide synthase activity is increased in patients with sepsis syndrome Helen F. GOODE, Peter D. HOWDLE, Barry E...

... synthase septic shock spleen Clinical Science (1594) 87, 179-186 (Printed in Great Britain) I 79 Cellular localization of inducible nitric oxide synthase in experimental endotoxic shock in the rat H. Terence COOK, Alison J. BUNE, Albertine S. JANSEN, G. Michael TAYLOR, Rashpal K. LO1 and Victoria...

..., including acute myocardial infarction, acute renal failure and essential hypertension. We determined the time course of plasma and pulmonary lymph endothelin-like immunoreactivity in relation to the progressive deterioration of cardiopulmonary function in an ovine septic shock model leading to multi-organ...

... 1970 The Biochemical Society and the Medical Research Society 1970 hypotension interleukin-1 septic shock tumour necrosis factor Clinical Science (1988) 75,251-255 25 1 Interleukin- 1 and tumour necrosis factor cause hypotension in the conscious rabbit J. R. WEINBERG, D. J. M. WRIGHT...