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Keywords: serotonin
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Clin Sci (Lond) (2005) 108 (5): 399–412.
Published: 22 April 2005
...Stephanie W. WATTS Since its discovery by Erspamer in the 1930s and identification by Page in the 1950s, 5-HT (5-hydroxytryptamine; serotonin) has been an elusive candidate as a substance that plays a role in the disease of high blood pressure, also known as hypertension. In both animal and human...
Clin Sci (Lond) (2000) 98 (6): 643–648.
Published: 17 May 2000
...Gerald P. MCCANN; Helen CAHILL; Stephen KNIPE; Douglas F. MUIR; Paul D. MACINTYRE; W. Stewart HILLS 5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the perception of exercise-induced fatigue. Sumatriptan is a selective 5-HT 1B/D receptor agonist which does not cross the blood–brain...
Clin Sci (Lond) (1984) 66 (4): 443–451.
Published: 01 April 1984
..., contractile responses produced by the platelets 1 min after aggregation were significantly reduced. They were then not significantly different from those produced by addition of the aliquots 20 min after aggregation, which were unaffected. 4. Pretreatment of the arteries with the serotonin antagonist...
Clin Sci (Lond) (1982) 63 (s8): 323s–326s.
Published: 01 October 1982
...R. Laguzzi; W. T. Talman; D. J. Reis 1. Highly localized microinjections of serotonin into the nucleus tractus solitarius in rats produced dose-dependent hypotension and bradycardia and electroencephalogram (EEG) changes consistent with an alerting response. 2. Microinjection of the serotinin...
Clin Sci (Lond) (1980) 59 (6): 505–508.
Published: 01 December 1980
...J. Dawson; M. G. Bryant; A. G. Cox; N. D. Christofides; S. R. Bloom; T. J. Peters 1. Analytical subcellular fractionation techniques have been applied to human jejunal homogenates to study the localization of serotonin and motilin. 2. Serotonin, detected by a fluorimetric assay, showed two distinct...
Clin Sci Mol Med (1976) 51 (s3): 427s–430s.
Published: 01 December 1976
...W. J. Louis; B. Jarrott; A. E. Doyle 1. Studies with a sensitive radioenzymatic assay for plasma noradrenaline suggest there is a selective overactivity of the sympathetic nervous system in essential hypertension. 2. Serotonin turnover in the mesenteric vessels is approximately twice...