...Stephanie W. WATTS Since its discovery by Erspamer in the 1930s and identification by Page in the 1950s, 5-HT (5-hydroxytryptamine; serotonin) has been an elusive candidate as a substance that plays a role in the disease of high blood pressure, also known as hypertension. In both animal and human...

...Gerald P. MCCANN; Helen CAHILL; Stephen KNIPE; Douglas F. MUIR; Paul D. MACINTYRE; W. Stewart HILLS 5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the perception of exercise-induced fatigue. Sumatriptan is a selective 5-HT 1B/D receptor agonist which does not cross the blood–brain...

...Mikael Lördal; Håkan Wallén; Paul Hjemdahl; Olof Beck; Per M. Hellström 1. The influence of circulating 5-hydroxytryptamine (serotonin) on small intestinal motility was investigated in healthy volunteers. 2. Small intestinal motility was studied by means of a constantly perfused multi-channel...

..., contractile responses produced by the platelets 1 min after aggregation were significantly reduced. They were then not significantly different from those produced by addition of the aliquots 20 min after aggregation, which were unaffected. 4. Pretreatment of the arteries with the serotonin antagonist...

... of angiotensin II. 1 6 1983 18 7 1983 © 1984 The Biochemical Society and the Medical Research Society 1984 aldosterone angiotensin blood pressure catecholamines haemodynamics 5-hydroxytryptamine ketanserin renin serotonin Clinical Science (1984) 66, 17-25 17 Responses...

...R. Laguzzi; W. T. Talman; D. J. Reis 1. Highly localized microinjections of serotonin into the nucleus tractus solitarius in rats produced dose-dependent hypotension and bradycardia and electroencephalogram (EEG) changes consistent with an alerting response. 2. Microinjection of the serotinin...

... radioimmunoassays. 2. The stimulants potassium, adrenocorticotropic hormone (ACTH), serotonin and adenosine 3′:5′-cyclic monophosphate (cyclic AMP), at concentrations which gave marked increases in steroid output, had no significant effect on the rate of 45 Ca efflux from capsular cell preparations (mainly zona...

...J. Dawson; M. G. Bryant; A. G. Cox; N. D. Christofides; S. R. Bloom; T. J. Peters 1. Analytical subcellular fractionation techniques have been applied to human jejunal homogenates to study the localization of serotonin and motilin. 2. Serotonin, detected by a fluorimetric assay, showed two distinct...

...W. J. Louis; B. Jarrott; A. E. Doyle 1. Studies with a sensitive radioenzymatic assay for plasma noradrenaline suggest there is a selective overactivity of the sympathetic nervous system in essential hypertension. 2. Serotonin turnover in the mesenteric vessels is approximately twice...