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Articles

Using serpins cysteine protease cross-specificity to possibly trap SARS-CoV-2 Mpro with reactive center loop chimera

In Collection
Coronavirus
Mohamad Aman Jairajpuri, Shoyab Ansari
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2235–2241.
https://doi.org/10.1042/CS20200767
Published: 01 September 2020
...Mohamad Aman Jairajpuri; Shoyab Ansari Human serine protease inhibitors (serpins) are the main inhibitors of serine proteases, but some of them also have the capability to effectively inhibit cysteine proteases. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) main protease (Mpro...
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Articles

PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases

Xuemin He, Rui Cheng, Siribhinya Benyajati, Jian-xing Ma
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (11): 805–823.
https://doi.org/10.1042/CS20130463
Published: 19 March 2015
...Xuemin He; Rui Cheng; Siribhinya Benyajati; Jian-xing Ma Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles in many physiological and pathophysiological processes...
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Articles

Loop—Sheet Polymerization: The Structural Basis of Z α 1 -Anti Trypsin Accumulation in the Liver

David A. Lomas
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (5): 489–495.
https://doi.org/10.1042/cs0860489
Published: 01 May 1994
... the plasma of a homozygote was present as long chains of polymers identical with those of Z antitrypsin. © 1994 The Biochemical Society and the Medical Research Society 1994 antitrypsin cirrhosis liver loop—sheet polymerization proteinase inhibitor serpin Clinical Science (1994) 86, 489-495...
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