... diseases, however, its function in acute liver injury is currently unknown. We analysed miR-192-5p serum levels and hepatic miR-192-5p expression in mice after hepatic ischaemia and reperfusion (I/R) as well as in toxic liver injury. On a functional level, miRNA levels were analysed in the different...

... serum miRNAs as biomarkers for liver pathologies. Real-time qPCR (quantitative PCR)-based TaqMan MicroRNA arrays were first employed to profile miRNAs in serum pools from patients with HCC (hepatocellular carcinoma) or LC (liver cirrhosis) and from healthy controls. Five miRNAs (i.e. miR - 885 - 5p...

... by coronary ligation, we found that serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated. The miR-1 level returned to basal levels at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI had a strong positive correlation...

...Fortunato SCALERA; Tina FISCHER; Dietmar SCHLEMBACH; Ernst BEINDER This study was conducted to compare the effects of serum from healthy pregnant women and that from pregnant women with pre-eclampsia on oxidative stress in endothelial cells in culture. Human umbilical vein endothelial cells (HUVECs...

...A. J. A. Al-Modhefer; M. W. B. Bradbury; T. J. B. Simons 1. The binding of lead to human blood serum, and components of serum, was studied by titration with the addition of Pb(NO 3 ) 2 solution, monitoring the free Pb 2+ concentration with a Pb 2+ electrode, and by equilibrium dialysis. 2. In fresh...

...John W. Barlow; Lorna E. Raggatt; Chen-Fee Lim; Sharon L. Munro; Duncan J. Topliss; Jan R. Stockigt 1. We studied a brominated thyroid hormone analogue, SKF L-94901, which has the potential to lower serum cholesterol without adverse cardiovascular effects. This compound is about 50% as active...

... diet, the concentration of p -cresol and urea in serum decreased in the two uraemic patients studied. The serum concentration of phenol was uninfluenced by this change of diet. 3. One female patient was studied during treatment with peritoneal dialysis, which on two out of three occasions appeared...

...P. W. Taylor 1. The serum of two patients with infections of the upper urinary tract contained a specific factor which inhibited its bactericidal action against the Gram-negative organism causing the infection. 2. The serum of the patients was fractionated by gel filtration and anion-exchange...