... formation of the infarcted left ventricle (LV). However, this can lead to chronic systemic inflammation and persistent autoimmune responses. In this study, we analyzed sex differences in the inflammatory autoimmune response to chronic MI. MI was induced by permanent left coronary artery ligation in adult...

... the current understanding of salt sensitivity, delving into its underlying mechanisms, the role of inflammation, and the influence of aging and sex differences on these processes. We also aim to provide insights into the multifaceted nature of salt sensitivity and its implications for personalized treatment...

... resistance arteries, and LDN 27219 induced vasorelaxation, selectively enhancing ACh relaxation in non-diabetic females, likely owing to increased TG2 expression. This finding underscores the importance of sex differences in TG2 modulation of vasorelaxation. Prior to sample analysis, primers were optimized...

...: Debra I. Diz ( [email protected] ) 18 05 2018 04 07 2018 19 07 2018 19 07 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 fetal programming hypertension mitogen-activated protein kinases sex differences...

... 07 2017 09 10 2017 03 11 2017 03 11 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 hypertension pregnancy relaxin sex differences Hypertension is the leading risk factor for cardiovascular disease...

...), sex hormones (oestrogen and androgen), epigenetic regulation and environmental factors all contribute to sex differences. Ischaemic sensitivity varies over the lifespan, with females having an “ischaemia resistant” phenotype that wanes after menopause, which has recently been modelled...

... despite the fact that both men and women develop hypertension. This is especially problematic since hypertension is well recognized as having distinct sex differences in the prevalence, absolute BP values and molecular mechanisms contributing to the pathophysiology of the disease. The purpose...

... that therapies targeting the RAS could be optimized for discrete epochs in life. aging angiotensin receptors cardiovascular disease hypertension sex differences The renin–angiotensin system (RAS) is a key regulator of arterial pressure and water and electrolyte balance in health and disease...

... of SCM occur in women Coronary heart disease Sex differences in risk factors • Higher rates of hypertension, physical inactivity • Diabetes and smoking confer greater risk of CHD compared with men • Female-specific risk factors of post-menopausal changes and pregnancy-related...

... of chronic disease. Sex has an impact on the severity of cardiovascular risk in experimental models of developmental insult. Yet, few studies examine the influence of sex on blood pressure and cardiovascular health in low-birth weight men and women. Fewer still assess the impact of ageing on sex differences...

..., better cardiac function and less heart failure development. cardiac function fibrosis myocardial infarction oestrogen receptor β sex differences • The lower incidence of ischaemic cardiomyopathy in pre-menopausal women compared with age-matched men raises the crucial question about...

...N. Orzes; S. Bellentani; R. Aldini; P. Simoni; I. Ferretti; G. C. Lunazzi; G. L. Sottocasa; C. Tiribelli 1. Sex difference in the hepatic uptake of sulphobromophthalein (BSP) was investigated in male and female rats in three different experimental models. 2. In the intact animal the BSP plasma...

...Maurizio Muraca; Jan De Groote; Johan Fevery 1. Hepatic bilirubin UDP-glucuronosyltransferase activity was higher in female than in male rats; gonadectomy decreased enzyme activity in females and increased it in males. This sex difference in bilirubin conjugation was further used to evaluate...