... inhibition (ACEi) in a sheep model of SFK delays onset of kidney dysfunction. We hypothesized that modulation of the renin–angiotensin system via brief postnatal ACEi in SFK would reprogram renal sodium and water handling. Here, blood pressure (BP), kidney haemodynamics and kidney excretory function were...

... secretion of the natriuretic peptides, hormones with actions beneficial in this disease. The present study investigates the roles of AngII and ET-1 in regulating the stretch-induced release of the natriuretic peptides during the development of heart failure. On seven separate days, eight sheep underwent...

... as an anticancer agent. During IL-2 therapy, adverse effects, such as vasodilatation and hypotension, are common. Previous studies suggest that these effects are due to nitric oxide (NO). Therefore a model of IL-2-induced hyperdynamic response in sheep was developed to test the effect of pyridoxalated haemoglobin...

...Kathryn L. GATFORD; E. Marelyn WINTOUR; Miles J. DE BLASIO; Julie A. OWENS; Miodrag DODIC Numerous epidemiological studies have related an increased risk of adult-onset cardiovascular and metabolic disease to an adverse intra-uterine environment at critical periods. We have shown that fetal sheep...

... diseases later in life. We were the first to show that sheep exposed to dexamethasone (0.28 mg⋅kg -1 ⋅day -1 for only 2 days) at the end of the first month of pregnancy (PTG1), but not those exposed at the end of the second month of pregnancy (PTG2), had a higher basal mean arterial pressure (MAP) 19...

... of the latter on blood gases and vertical distribution of blood flow within the two lungs. 2. Serial infusions of radioactive or fluorescent microspheres were given to each of seven adult standing sheep before, during occlusion of the left mainstem bronchus for up to 6 min, and after release of occlusion...

... and adrenocorticotropic hormone in these sheep at any of the ages studied, nor did it affect basal or adrenocorticotropic hormone-induced concentrations of Cortisol or basal plasma renin concentrations in the lambs at any age. 4. These data support the hypothesis that excess glucocorticoid exposure in early pregnancy...

...Barbara S. Polla; Josiane Clerc; Jean-François Pittet; Denis R. Morel 1. We have studied the time course of the numbers of arterial monocytes and their superoxide anion (O 2 − ) production in a chronically instrumented sheep model of subacute endotoxaemia induced by a continuous intravenous...

...B. A. Scoggins; J. P. Coghlan; D. A. Denton; Maureen Fitzgerald; W. F. Graham; R. T. Mason; E. G. Schneider 1. ACTH administration (20 μg day −1 kg −1 ) to sheep produces hypertension associated with a raised cardiac output and hypokalaemia. 2. The aim of the present experiments was to detail...

...B. A. Scoggins; K. J. F. Allen; J. P. Coghlan; D. A. Denton; W. F. Graham; T. J. Humphery; Judith A. Whitworth 1. Administration of adrenocorticotropic hormone (ACTH) to sheep produced increases in mean arterial pressure within 24 h associated with an increase in cardiac output and cardiac rate...

... bacterial pyrogen and leucocyte pyrogen appears to depend upon the maturity of the physiological mechanisms involved in pyrogen fever. 22 10 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 fever pyrogen newborn sheep Clinical Science and Molecular Medicine...