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Keywords: signal transduction
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Clin Sci (Lond) (2019) 133 (24): 2481–2498.
Published: 23 December 2019
... The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hes Hey Notch receptors pulmonary arteries signal transduction vascular smooth muscle cells...
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Clin Sci (Lond) (2015) 128 (9): 559–565.
Published: 11 February 2015
... transduction • No pharmacological treatment has been established that can inhibit or slow AAA development and rupture. We have shown that EGFR ‘trans’-activation is a critical signal transduction of Ang II in VSMC. • In the present study, we demonstrated that a pharmacological inhibition of EGFR...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 122 (8): 361–368.
Published: 14 December 2011
... tyrosine kinase signal transduction vascular disease Axl, an RTK (receptor tyrosine kinase), derives its name from the Greek word anexelekto which means uncontrolled. Axl was initially discovered in cancer cells over two decades ago [ 1 ]. Axl is a founder of a unique TAM (Tyro3, Axl and Mertk...
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Clin Sci (Lond) (2010) 118 (8): 519–526.
Published: 26 January 2010
... , 16 ]. FcγRIIb, an ITIM-containing receptor, is the only inhibitory FcγR. It is expressed on B cells, mast cells, macrophages, monocytes and neutrophils, and inhibits pro-inflammatory functions of these cells [ 15 , 16 ]. acute lung injury FcγRIIa IgG receptor lung signal transduction...
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Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
.... Correspondence: Dr Philip Newsholme (email [email protected] ). 5 10 2004 10 11 2004 15 11 2004 15 11 2004 The Biochemical Society 2005 amino acids apoptosis diabetes gene expression metabolism mitochondria signal transduction Thus a relatively small number...
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Clin Sci (Lond) (1997) 92 (5): 445–451.
Published: 01 May 1997
... factors. Recently, mutations in a G-protein (constitutively-activated Gs,) and in a seven-transmembrane-region receptor (constitutively Key words: cell proliferation, protein kinase, signal transduction. Abbreviations: E-Brd, &bromoadenosine 3',5'-cyclic monophosphate; CAMP, cyclic AMP; MAPK, mitogen...
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Clin Sci (Lond) (1996) 91 (5): 527–537.
Published: 01 November 1996
... states that G-proteins undergo as they are activated and deactivated and has provided great insight into the kinetic models of G-protein-mediated signal transduction. 3. The regulation of adenylate cyclase has proven to be intriguing and complex. G sα activates all forms of mammalian adenylate cyclase...
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Clin Sci (Lond) (1995) 89 (3): 227–232.
Published: 01 September 1995
...Samuel S. Lee; Jung-Min Pak; Shaun M. Medlicott; Arieh Bomzon 1. There is currently considerable interest in the role of locally produced vasodilators such as nitric oxide and adenosine in the pathogenesis of the peripheral vasodilatation of cirrhosis. However, the signal transduction pathways...