... The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hes Hey Notch receptors pulmonary arteries signal transduction vascular smooth muscle cells...

... transduction • No pharmacological treatment has been established that can inhibit or slow AAA development and rupture. We have shown that EGFR ‘trans’-activation is a critical signal transduction of Ang II in VSMC. • In the present study, we demonstrated that a pharmacological inhibition of EGFR...

... to vascular structural remodelling including neointimal hyperplasia. The present study suggests DAPK3 as a novel pharmaceutical target for the prevention of hypertensive cardiovascular diseases. death-associated protein kinase 3 (DAPK3) growth factor hyperplasia hypertension signal transduction...

... after gonadectomy. G-protein-coupled receptor (GPCR) kinin B 1 receptor muscle atrophy protein metabolism signal transduction ubiquitin–proteasome system • As the kinin B 1 receptor activates signalling pathways that are also known to be involved in skeletal muscle catabolic...

... tyrosine kinase signal transduction vascular disease Axl, an RTK (receptor tyrosine kinase), derives its name from the Greek word anexelekto which means uncontrolled. Axl was initially discovered in cancer cells over two decades ago [ 1 ]. Axl is a founder of a unique TAM (Tyro3, Axl and Mertk...

... by a post-hoc testing (Newman–Keuls test). Values of P ≤0.05 were considered statistically significant. Values are shown as means±S.E.M. © The Authors Journal compilation © 2011 Biochemical Society 2011 β-catenin limb ischaemia myocardial infarction signal transduction remote ischaemic...

... , 16 ]. FcγRIIb, an ITIM-containing receptor, is the only inhibitory FcγR. It is expressed on B cells, mast cells, macrophages, monocytes and neutrophils, and inhibits pro-inflammatory functions of these cells [ 15 , 16 ]. acute lung injury FcγRIIa IgG receptor lung signal transduction...

... The Authors Journal compilation © 2007 Biochemical Society 2007 focal adhesion kinase (FAK) heart failure hypertrophy myocardial fibrosis signal transduction volume overload Cardiac diseases often result in adverse remodelling of the left ventricle and progression to heart failure. Complex...

... 5 4 2005 9 5 2005 The Biochemical Society 2005 angiogenesis inflammation signal transduction tumour vascular endothelial growth factor (VEGF) vascular permeability Angiogenesis and vasculogenesis are regulated predominantly by several different growth factors...

.... Correspondence: Dr Philip Newsholme (email [email protected] ). 5 10 2004 10 11 2004 15 11 2004 15 11 2004 The Biochemical Society 2005 amino acids apoptosis diabetes gene expression metabolism mitochondria signal transduction Thus a relatively small number...

... Nick Anim-Nyame (e-mail [email protected] ). 29 1 2003 19 6 2003 30 7 2003 30 7 2003 © 2004 The Biochemical Society 2004 blood flow conducted dilatation pre-eclampsia signal transduction Clinical Science (2004) 106, 19 25 (Printed in Great Britain) 19 Impaired...

... C pathways. angiopoietin-2 cell culture cyclical stretch gene expression signal transduction Tie receptor Correspondence: Dr Kou-Gi Shyu, MD, Division of Cardiology, 95 Wen-Chang Rd, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan (e-mail [email protected] ). 29...

... factors. Recently, mutations in a G-protein (constitutively-activated Gs,) and in a seven-transmembrane-region receptor (constitutively Key words: cell proliferation, protein kinase, signal transduction. Abbreviations: E-Brd, &bromoadenosine 3',5'-cyclic monophosphate; CAMP, cyclic AMP; MAPK, mitogen...

... states that G-proteins undergo as they are activated and deactivated and has provided great insight into the kinetic models of G-protein-mediated signal transduction. 3. The regulation of adenylate cyclase has proven to be intriguing and complex. G sα activates all forms of mammalian adenylate cyclase...

...Samuel S. Lee; Jung-Min Pak; Shaun M. Medlicott; Arieh Bomzon 1. There is currently considerable interest in the role of locally produced vasodilators such as nitric oxide and adenosine in the pathogenesis of the peripheral vasodilatation of cirrhosis. However, the signal transduction pathways...