... The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hes Hey Notch receptors pulmonary arteries signal transduction vascular smooth muscle cells...

... of EGFR-linked signal transduction in mouse and human AAA ( A ) C57BL/6 mice were treated with Ang II plus BAPN with or without erlotinib as in Figure 1 . Representative staining of AA with Masson's Trichrome (MT) and the indicated antibodies were presented ( n =4 in each group, 200X). ( B ) Human aorta...

... proliferation and migration. Our novel data suggest DAPK3 as a pharmaceutical target for the prevention of hypertensive cardiovascular diseases. death-associated protein kinase 3 (DAPK3) growth factor hyperplasia hypertension signal transduction • DAPK3 is a serine/threonine kinase...

... metabolism signal transduction ubiquitin–proteasome system In the present study, we made use of various approaches and tools, including in vitro assays with C2C12 cell myotubes, animal treatment with selective antagonists and the use of knockout mice, to address the contribution of the kinin B 1...

... [ 21 ]. Therefore ligand-independent activation of Axl is more typical during pathophysiological conditions with increases in oxidative stress and excess receptor expression. Axl autoimmunity cancer receptor tyrosine kinase signal transduction vascular disease Axl, an RTK (receptor...

... andrew.redington@sickkids.ca ). 17 9 2010 17 11 2010 8 12 2010 8 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 β-catenin limb ischaemia myocardial infarction signal transduction remote ischaemic preconditioning The phenomenon of local IPC...

... with ALI/ARDS [ 10 , 11 ]. Furthermore, anti-IL-8 autoantibody/IL-8 immune complexes are found in association with FcγRIIa (Fcγ receptor IIa) in pulmonary tissues from these patients [ 14 ]. acute lung injury FcγRIIa IgG receptor lung signal transduction ALI and the ARDS were first...

... ). 19 1 2007 16 4 2007 11 5 2007 11 5 2007 focal adhesion kinase (FAK) heart failure hypertrophy myocardial fibrosis signal transduction volume overload Cardiac diseases often result in adverse remodelling of the left ventricle and progression to heart failure...

... Society 2005 angiogenesis inflammation signal transduction tumour vascular endothelial growth factor (VEGF) vascular permeability Angiogenesis and vasculogenesis are regulated predominantly by several different growth factors and their associated RTKs (receptor tyrosine kinases...

... amino acids apoptosis diabetes gene expression metabolism mitochondria signal transduction In vivo , the β-cell is constantly monitoring nutrient availability and metabolic status and can generate appropriate secondary stimulus-coupling signals in response to the most minor changes...

... Nick Anim-Nyame (e-mail n.anim@ic.ac.uk ). 29 1 2003 19 6 2003 30 7 2003 30 7 2003 © 2004 The Biochemical Society 2004 blood flow conducted dilatation pre-eclampsia signal transduction Clinical Science (2004) 106, 19 25 (Printed in Great Britain) 19 Impaired...

... 2003 2003 angiopoietin-2 cell culture cyclical stretch gene expression signal transduction Tie receptor 421Clinical Science (2003) 104, 421 428 (Printed in Great Britain) Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein...

... characterized by inappropriate activation of growth factor signalling pathways. © 1997 The Biochemical Society and the Medical Research Society 1997 cell proliferation protein kinase signal transduction Clinical Science (1997) 92,445-45 I (Printed in Great Britain) 445 Glaxo/MRS Young Investigator...

... states that G-proteins undergo as they are activated and deactivated and has provided great insight into the kinetic models of G-protein-mediated signal transduction. 3. The regulation of adenylate cyclase has proven to be intriguing and complex. G sα activates all forms of mammalian adenylate cyclase...

...Samuel S. Lee; Jung-Min Pak; Shaun M. Medlicott; Arieh Bomzon 1. There is currently considerable interest in the role of locally produced vasodilators such as nitric oxide and adenosine in the pathogenesis of the peripheral vasodilatation of cirrhosis. However, the signal transduction pathways...