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Keywords: signal transduction
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Articles
Clin Sci (Lond) (2019) 133 (24): 2481–2498.
Published: 23 December 2019
... The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hes Hey Notch receptors pulmonary arteries signal transduction vascular smooth muscle cells...
Articles
Clin Sci (Lond) (2015) 128 (9): 559–565.
Published: 11 February 2015
... transduction • No pharmacological treatment has been established that can inhibit or slow AAA development and rupture. We have shown that EGFR ‘trans’-activation is a critical signal transduction of Ang II in VSMC. • In the present study, we demonstrated that a pharmacological inhibition of EGFR...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (8): 539–548.
Published: 02 July 2014
... proliferation and migration. Our novel data suggest DAPK3 as a pharmaceutical target for the prevention of hypertensive cardiovascular diseases. death-associated protein kinase 3 (DAPK3) growth factor hyperplasia hypertension signal transduction • DAPK3 is a serine/threonine kinase...
Articles
Clin Sci (Lond) (2014) 127 (3): 185–194.
Published: 03 April 2014
...) kinase]/NF-κB and PI3K/Akt pathways revealing a new role for the KKS (kallikrein–kinin system) in muscle mass control. G-protein-coupled receptor (GPCR) kinin B 1 receptor muscle atrophy protein metabolism signal transduction ubiquitin–proteasome system • As the kinin B 1...
Articles
Clin Sci (Lond) (2012) 122 (8): 361–368.
Published: 14 December 2011
... tyrosine kinase signal transduction vascular disease Axl, an RTK (receptor tyrosine kinase), derives its name from the Greek word anexelekto which means uncontrolled. Axl was initially discovered in cancer cells over two decades ago [ 1 ]. Axl is a founder of a unique TAM (Tyro3, Axl and Mertk...
Articles
Clin Sci (Lond) (2011) 120 (10): 451–462.
Published: 28 January 2011
... 8 12 2010 8 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 β-catenin limb ischaemia myocardial infarction signal transduction remote ischaemic preconditioning The phenomenon of local IPC (ischaemic preconditioning) induced by short periods...
Articles
Clin Sci (Lond) (2010) 118 (8): 519–526.
Published: 26 January 2010
... lung signal transduction ALI and the ARDS were first described in 1967 and represent a severe form of diffuse lung disease. Alternations of lung function in these pathological entities include rapid onset of dyspnoea, hypoxaemia and respiratory failure. The alveolar-capillary barrier becomes...
Articles
Clin Sci (Lond) (2007) 113 (4): 195–204.
Published: 13 July 2007
... The Authors Journal compilation © 2007 Biochemical Society 2007 focal adhesion kinase (FAK) heart failure hypertrophy myocardial fibrosis signal transduction volume overload Cardiac diseases often result in adverse remodelling of the left ventricle and progression to heart failure. Complex...
Articles
Clin Sci (Lond) (2005) 109 (3): 227–241.
Published: 24 August 2005
... Society 2005 angiogenesis inflammation signal transduction tumour vascular endothelial growth factor (VEGF) vascular permeability Angiogenesis and vasculogenesis are regulated predominantly by several different growth factors and their associated RTKs (receptor tyrosine kinases...
Articles
Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
... amino acids apoptosis diabetes gene expression metabolism mitochondria signal transduction Amino acid metabolism, under appropriate conditions, is known to enhance insulin secretion from primary islet cells and β-cell lines [ 1 – 5 ]. In vivo , L -glutamine and L -alanine...
Articles
Clin Sci (Lond) (2004) 106 (1): 19–25.
Published: 01 January 2004
... dilatation pre-eclampsia signal transduction Correspondence: Dr Nick Anim-Nyame (e-mail n.anim@ic.ac.uk ). 29 1 2003 19 6 2003 30 7 2003 30 7 2003 © 2004 The Biochemical Society 2004 Clinical Science (2004) 106, 19 25 (Printed in Great Britain) 19 Impaired...
Articles
Clin Sci (Lond) (2003) 104 (4): 421–428.
Published: 20 March 2003
... 2003 2003 angiopoietin-2 cell culture cyclical stretch gene expression signal transduction Tie receptor 421Clinical Science (2003) 104, 421 428 (Printed in Great Britain) Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein...
Articles
Clin Sci (Lond) (1997) 92 (5): 445–451.
Published: 01 May 1997
... characterized by inappropriate activation of growth factor signalling pathways. © 1997 The Biochemical Society and the Medical Research Society 1997 cell proliferation protein kinase signal transduction Clinical Science (1997) 92,445-45 I (Printed in Great Britain) 445 Glaxo/MRS Young Investigator...
Articles
Clin Sci (Lond) (1996) 91 (5): 527–537.
Published: 01 November 1996
... states that G-proteins undergo as they are activated and deactivated and has provided great insight into the kinetic models of G-protein-mediated signal transduction. 3. The regulation of adenylate cyclase has proven to be intriguing and complex. G sα activates all forms of mammalian adenylate cyclase...
Articles
Clin Sci (Lond) (1995) 89 (3): 227–232.
Published: 01 September 1995
...Samuel S. Lee; Jung-Min Pak; Shaun M. Medlicott; Arieh Bomzon 1. There is currently considerable interest in the role of locally produced vasodilators such as nitric oxide and adenosine in the pathogenesis of the peripheral vasodilatation of cirrhosis. However, the signal transduction pathways...