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Keywords: single nucleotide polymorphism
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Articles

MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S -adenosylmethionine and de novo purine synthesis

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Yi-Cheng Wang, Ming-Tsung Wu, Feng-Yao Tang, Der-Yuan Chen, Hsin-An Ko, Barry Shane, Wen-Nan Huang, En-Pei Isabel Chiang
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (2): 253–267.
https://doi.org/10.1042/CS20180932
Published: 25 January 2019
... Isabel Chiang ( [email protected] ) 01 11 2018 24 12 2018 01 01 2019 03 01 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 folate Metabolism Nutrition rheumatoid arthritis single nucleotide polymorphism...
View articletitled, MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S -adenosylmethionine and de novo purine synthesis
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Articles

Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites

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Ying-Ying Yang, Han-Chieh Lin, Ming-Wei Lin, Chi-Jen Chu, Fa-Yauh Lee, Ming-Chih Hou, Shou-Dong Lee, Wei-Ping Lee, Tze-Tze Liu, Tjin-Shing Jap
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (11): 509–521.
https://doi.org/10.1042/CS20110018
Published: 09 August 2011
... handling system. We hypothesized that SNPs (single nucleotide polymorphisms) affecting candidate genes in the RAAS and renal sodium handling pathway may influence initial diuretic responsiveness and affect clinical outcome in non-azotaemic cirrhotic patients with moderate ascites. We prospectively...
View articletitled, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites
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Includes: Supplementary data
Articles

Hunting for fibrosis progression genes in hepatitis C patients

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Pietro Invernizzi
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (7): 285–286.
https://doi.org/10.1042/CS20100553
Published: 13 December 2010
... fatty liver disease (NAFLD) single nucleotide polymorphism viral hepatitis HCV (hepatitis C virus) infection is often asymptomatic but, once established, chronic infection can progress to scarring of the liver (i.e. fibrosis) and, generally after many years, to advanced scarring (i.e. cirrhosis...
View articletitled, Hunting for fibrosis progression genes in hepatitis C patients
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Articles

A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease

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Rika Iwata, Katharina Baur, Bruno Stieger, Joachim C. Mertens, Ann K. Daly, Pascal Frei, Julia Braun, Athanasios Vergopoulos, Felix Stickel, Karim Sabrane, Ina V. Martin, Johannes Schmitt, Oliver Goetze, Chris P. Day, Beat Müllhaupt, Andreas Geier, the Swiss Hepatitis C Cohort Study Group
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (7): 287–296.
https://doi.org/10.1042/CS20100246
Published: 13 December 2010
... Biochemical Society 2011 bile acid transport bile salt export pump (BSEP) cirrhosis farnesoid X receptor (FXR) non-alcoholic fatty liver disease (NAFLD) single nucleotide polymorphism viral hepatitis With more than 170 million people infected worldwide, chronic HCV (hepatitis C virus...
View articletitled, A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease
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Articles

The RANTES −403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease

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Yangsoo Jang, Jey Sook Chae, Yae Jung Hyun, Soo Jeong Koh, Ji Young Kim, Min Ji Ko, Se-Joong Rim, Hyun-Joon Shin, Jose M. Ordovas, Jong Ho Lee
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (8): 349–356.
https://doi.org/10.1042/CS20070014
Published: 12 September 2007
...>A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54–0.92], P =0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the −403G...
View articletitled, The RANTES −403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease
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Articles

Leukotriene B 4 production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction

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Annette Maznyczka, Massimo Mangino, Andrew Whittaker, Peter Braund, Tom Palmer, Martin Tobin, Alison H. Goodall, Peter Bradding, Nilesh J. Samani
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (7): 411–416.
https://doi.org/10.1042/CS20060271
Published: 01 March 2007
... J. Samani (email [email protected] ). 25 9 2006 11 12 2006 18 12 2006 18 12 2006 The Biochemical Society 2007 arachidonate 5-lipoxygenase-activating protein (ALOX5AP) cardiovascular risk leukotriene myocardial infarction single nucleotide polymorphism MI...
View articletitled, Leukotriene B 4 production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction
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Articles

Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population

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Wei Yang, Wentao Huang, Shaoyong Su, Biao Li, Weiyan Zhao, Shufeng Chen, Dongfeng Gu
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (5): 333–340.
https://doi.org/10.1042/CS20060020
Published: 13 October 2006
.... This prompted us to perform a case-control study to investigate the relationship of ACE2 polymorphisms with CHD (coronary heart disease) and MI (myocardial infarction). Three single nucleotide polymorphisms in the ACE2 gene (1075A/G, 8790A/G and 16854G/C) were genotyped by PCR-RFLP (restriction-fragment-length...
View articletitled, Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population
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Articles

CETP (cholesteryl ester transfer protein) promoter −1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia

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Mutsuko Takata, Akihiro Inazu, Shoji Katsuda, Kenji Miwa, Masa-aki Kawashiri, Atsushi Nohara, Toshinori Higashikata, Junji Kobayashi, Hiroshi Mabuchi, Masakazu Yamagishi
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (5): 325–331.
https://doi.org/10.1042/CS20060088
Published: 13 October 2006
... (CETP) coronary artery disease familial hypercholesterolaemia hepatic lipase single nucleotide polymorphism CETP (cholesteryl ester transfer protein) is a key player in the metabolism of major plasma lipoproteins. CETP mediates the transfer of cholesteryl esters from HDL (high-density...
View articletitled, CETP (cholesteryl ester transfer protein) promoter −1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia
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Articles

Linkage and linkage disequilibrium analysis of the lipoprotein lipase gene with lipid profiles in Chinese hypertensive families

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Wenjie YANG, Jianfeng HUANG, Cailiang YAO, Shaoyong SU, Donghai LIU, Dongliang GE, Dongfeng GU
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (2): 137–142.
https://doi.org/10.1042/CS20040101
Published: 21 January 2005
... SNPs (single nucleotide polymorphisms), Hin dIII and Hin fI, were found in linkage disequilibrium with LDL-cholesterol levels ( P =0.0178 and P =0.0088 respectively). A strong linkage disequilibrium was observed between the Hin dIII in intron 8 and Hin fI in the exon 9 ( P <0.00001, D ′=0.895...
View articletitled, Linkage and linkage disequilibrium analysis of the lipoprotein lipase gene with lipid profiles in Chinese hypertensive families
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Includes: Supplementary data