...Munehiro Kitada; Shinji Kume; Ai Takeda-Watanabe; Keizo Kanasaki; Daisuke Koya Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins, SIRT1–SIRT7. Among them, SIRT1, SIRT3 and SIRT6 are induced by calorie...

... eNOS and efforts to reverse eNOS uncoupling. SIRT1 (sirtuin 1), which regulates the expression and activity of multiple pro- and anti-oxidant enzymes, could be considered a candidate molecule for a ‘molecular switch’. Correspondence: Dr Ismail Laher (email [email protected] ). 8 11...

...Yoshiyuki Horio; Takashi Hayashi; Atsushi Kuno; Risa Kunimoto Sirtuins are NAD + -dependent protein deacetylases that are broadly conserved from bacteria to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention has been paid to their mammalian homologues. Recent...