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Keywords: sirtuin 1
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Articles

IGF2 deficiency causes mitochondrial defects in skeletal muscle

Open Access
Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 979–990.
https://doi.org/10.1042/CS20210128
Published: 16 April 2021
... the possible regulatory pathway and found that mitochondrial regulation in skeletal muscle cells might occur through IGF2-Sirtuin 1 (SIRT1)-peroxisome proliferator-activated receptor-γ co-activator-1α (PGC1α) signaling pathway. Therefore, the present study first demonstrated the relationship between IGF2...
View articletitled, IGF2 deficiency causes mitochondrial defects in skeletal muscle
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Includes: Supplementary data
Articles

Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia

Available to Purchase
Ching-Hsia Hung, Shih-Hung Chan, Pei-Ming Chu, Kun-Ling Tsai
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (6): 477–487.
https://doi.org/10.1042/CS20150127
Published: 22 June 2015
... (reactive oxygen species) formation and SIRT1 (sirtuin 1) degradation through a proteasome-dependent mechanism, thereby mitigating the activity of SIRT1 by deacetylating HSF1 (heat-shock transcription factor 1). We also found that NOX2 is a key NAPDH oxidase isoform responsible for the Hcy-caused ROS...
View articletitled, Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
Open the PDF for Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia in another window