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Keywords: skin
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Clin Sci (Lond) (2023) 137 (3): 239–250.
Published: 07 February 2023
...Jun Yu Chen; Khai Syuen Chew; Sheon Mary; Philipp Boder; Domenico Bagordo; Gian Paolo Rossi; Rhian M. Touyz; Christian Delles; Giacomo Rossitto Increasing evidence suggests excess skin Na + accumulation in hypertension; however, the role of skin-specific mechanisms of local Na + /water regulation...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (12): 935–952.
Published: 22 June 2022
... for this chronic disease. We consider both the skin and the musculoskeletal compartment and how different manifestations of psoriatic inflammation are linked. This review brings a focus to the importance of inflammatory feedback loops that exist in the initiation and chronic stages of the condition, and how close...
Clin Sci (Lond) (2022) 136 (8): 579–597.
Published: 21 April 2022
..., and disruption of the normal circadian rhythms has been linked to elevation of multiple health risks. The skin serves as a protective barrier to prevent microbial infection and maintain homoeostasis of the underlying tissue and the whole organism. However, in chronic non-healing wounds such as diabetic foot...
Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Published: 13 July 2017
...Steven Horsburgh; Nicola Fullard; Mathilde Roger; Abbie Degnan; Stephen Todryk; Stefan Przyborski; Steven O’Reilly The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each...
Clin Sci (Lond) (2011) 120 (3): 99–120.
Published: 20 October 2010
... biological processes, and this situation has been documented in active vitiligo skin. Tyrosinase activity is impaired by excess H 2 O 2 through oxidation of methionine residues in this key melanogenic enzyme. Mechanisms for repairing this oxidant damage are also damaged by H 2 O 2 , compounding the effect...
Clin Sci (Lond) (2003) 105 (5): 533–535.
Published: 01 November 2003
...Richard WELLER Nitric oxide (NO) is involved in several processes in the skin, including wound healing, pigmentation and regulation of apoptosis. Pharmacological intervention with NO donors appears to be a promising treatment for conditions such as diabetic ulceration. In this issue of Clinical...
Clin Sci (Lond) (2003) 105 (5): 577–584.
Published: 01 November 2003
... in decomposition rate between 19 and 37 °C. In the forearm of eight normal male subjects, we found that D -SNAG produced a significant dose-dependent vasodilator effect ( P =0.001) with good reproducibility (19%) on repeated testing. We propose that delivery of NO from D -SNAG to the forearm skin microvessels most...
Clin Sci (Lond) (2001) 101 (6): 567–572.
Published: 22 October 2001
..., methacholine, bradykinin and substance P were administered iontophoretically to the forearm skin of healthy volunteers on two to three occasions. Dose-dependent increases in skin microvascular blood flow in response to these drugs were measured with laser Doppler imaging. Vascular responses to acetylcholine...
Clin Sci (Lond) (2001) 100 (4): 395–400.
Published: 26 February 2001
... significant amounts of NO. The originally described system was messy and impractical, and the high acidity may cause pain and further tissue damage in ulcerated skin. To overcome this, a selectively permeable, hydrophilic polyester co-polymer membrane system (Sympatex™) has been identified that can be placed...
Clin Sci (Lond) (1995) 89 (1): 69–73.
Published: 01 July 1995
...Andrew E. Pocock; Martin J. O. Francis; Roger Smith 1. Skin fibroblast lines were cultured from nine patients who had the features of idiopathic juvenile osteoporosis, six relatives, five unrelated control subjects and three unrelated patients with osteogenesis imperfecta type I. Some patients...
Clin Sci (Lond) (1991) 81 (5): 611–619.
Published: 01 November 1991
... in the whole body. k s was selectively depressed in skeletal muscles, mainly owing to a reduced k RNA , and was not modified in heart, liver and skin. The contribution of skin to whole-body protein synthesis increased by 39%. 3. During the phase of protein sparing (5 days of fasting), k d in the whole body...
Clin Sci (Lond) (1982) 62 (6): 605–609.
Published: 01 June 1982
... 1981 14 12 1981 © 1982 The Biochemical Society and the Medical Research Society 1982 blood flow head-up tilt nervous blockade skin spinal reflex tetraplegia vasoconstrictor response veno-arteriolar reflex Clinical Science (1982) 62,605-609 605 Sympathetic reflex control...
Clin Sci (Lond) (1982) 62 (2): 243–245.
Published: 01 February 1982
.... The underlying mechanism may be neuronal inhibition, probably antidromic, in sympathetic fibres. 21 9 1981 5 10 1981 © 1982 The Biochemical Society and the Medical Research Society 1982 Acute myocardial infarction local suction skin subatmospheric pressure subcutaneous blood flow veno...
Clin Sci (Lond) (1981) 60 (5): 499–506.
Published: 01 May 1981
... 1980 © 1981 The Biochemical Society and the Medical Research Society 1981 blood circulation blood pressure oxygen skin vascular diseases venous pressure Clinical Science (198 I) 60, 499-506 Dependence of transcutaneous oxygen tension on local arteriovenous pressure gradient...
Clin Sci (Lond) (1980) 58 (3): 235–242.
Published: 01 March 1980
...M. Davie; D. E. M. Lawson 1. The response of 25-hydroxyvitamin D [25-(OH)D] to artificial ultraviolet irradiation applied to a known area of dorsal skin was investigated in 18 subjects, small quantities of ultraviolet energy being used. Ultraviolet irradiation was administered on days, 1, 3, 5, 8...
Clin Sci Mol Med (1976) 51 (5): 467–474.
Published: 01 November 1976
...M. J. O. Francis; M. C. Sanderson; R. Smith 1. Skin collagen from fifteen patients with idiopathic adolescent scoliosis, three with congenital scoliosis, and fourteen patients with various degrees of Marfan's syndrome has been examined. 2. The stability of a polymeric collagen fraction, extracted...
Clin Sci Mol Med (1976) 50 (4): 307–310.
Published: 01 April 1976
...C. D. Moutafis; N. B. Myant 1. The specific radioactivity of [ 14 C]cholesterol in plasma and in serial biopsies of muscle and skin was measured in Rhesus monkeys for 156 days after a single intravenous injection of [ 14 C]cholesterol. 2. Analysis of the specific radioactivity—time curves in terms...