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Clin Sci (Lond) (2014) 126 (4): 253–265.
Published: 14 October 2013
... cigarette smoke, causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T-cells are prominent, leads to oxidative stress, emphysema, small airways fibrosis and mucus hypersecretion. The mechanisms and mediators that drive the induction and progression of chronic...
Clin Sci (Lond) (2010) 118 (9): 565–572.
Published: 09 February 2010
...Nicholas S. Hopkinson; Michael I. Polkey COPD (chronic obstructive pulmonary disease) is the most common pulmonary disease and is the only common cause of death in which mortality is presently rising. It is caused by the inhalation of smoke, which leads to oxidative stress and inflammation both in...
Clin Sci (Lond) (2007) 113 (5): 233–241.
Published: 01 August 2007
... population. Smoking is a key lifestyle risk factor for bone loss and fractures that appears to be independent of other risk factors for fracture such as age, weight, sex and menopausal status. This review discusses the effects of smoking on bone health in pre-menopausal and post-menopausal women and men...
Clin Sci (Lond) (2006) 111 (1): 87–91.
Published: 14 June 2006
...-smoking group (2.2±0.5 and 4.5±0.8% respectively; P <0.05). In the smoking group, FMD increased significantly ( P <0.05) to 4.0±0.8% during treatment with atorvastatin and returned to basal levels during placebo (2.3±0.6%). In the non-smoking group, FMD was unaffected by both atorvastatin and...
Ting-Hsing CHAO, Yi-Heng LI, Jyh-Hong CHEN, Hua-Lin WU, Guey-Yueh SHI, Ping-Yen LIU, Wei-Chuan TSAI, How-Ran GUO
Clin Sci (Lond) (2004) 107 (5): 461–466.
Published: 26 October 2004
...)], smoking [OR (95% CI), 3.5, (2.1–6.0)], hypertension [OR (95% CI), 3.6, (1.9–6.9)] and diabetes mellitus [OR (95% CI), 3.5 (1.5–8.4)] were independent risk factors for premature AMI. Plasma levels of Ab-ox-LDL were significantly higher in healthy volunteers with the TT genotype compared with those with the...
Richard G. IJZERMAN, Erik H. SERNE, Mirjam M. van WEISSENBRUCH, Renate T. de JONGH, Coen D.A. STEHOUWER
Clin Sci (Lond) (2003) 104 (3): 247–252.
Published: 12 February 2003
...Richard G. IJZERMAN; Erik H. SERNE; Mirjam M. van WEISSENBRUCH; Renate T. de JONGH; Coen D.A. STEHOUWER An effect on microvascular function has been proposed as a possible mechanism explaining the association of acute smoking with increased blood pressure and decreased insulin sensitivity. However...
Junichi MINAMI, Masakatsu TODOROKI, Masayoshi YOSHII, Shinichiro MITA, Toshio NISHIKIMI, Toshihiko ISHIMITSU, Hiroaki MATSUOKA
Clin Sci (Lond) (2002) 103 (2): 117–122.
Published: 28 June 2002
...Junichi MINAMI; Masakatsu TODOROKI; Masayoshi YOSHII; Shinichiro MITA; Toshio NISHIKIMI; Toshihiko ISHIMITSU; Hiroaki MATSUOKA We investigated the effects of smoking cessation or alcohol restriction on metabolic and fibrinolytic variables in Japanese men. In the smoking study, 35 male subjects [32...
Clin Sci (Lond) (2001) 101 (1): 53–58.
Published: 24 May 2001
...Robert BUTLER; Andrew D. MORRIS; Allan D. STRUTHERS Cigarette smoking is a pernicious risk factor for the pathogenesis of coronary artery disease, and endothelial dysfunction is an important antecedent event in this process. This is important, as cigarette smoke is directly toxic to endothelial...
Clin Sci (Lond) (2001) 100 (6): 661–665.
Published: 14 May 2001
...Katherine M. ENGLISH; Peter J. PUGH; Helen PARRY; Nanette E. SCUTT; Kevin S. CHANNER; T. Hugh JONES The effect of smoking on androgen levels is important given the recent interest in the link between low levels of androgens and the development of cardiovascular disease. Numerous studies examining...
Clin Sci (Lond) (2000) 99 (1): 65–75.
Published: 15 June 2000
... decompression illness contrast echocardiography decompression sickness gas embolism lung function tests patent foramen ovale pulmonary arteriovenous fistula pulmonary barotrauma smoking spinal decompression illness 65Clinical Science (2000) 99, 65 75 (Printed in Great Britain) Relationship between...
Clin Sci (Lond) (1996) 91 (5): 621–626.
Published: 01 November 1996
...J. H. Knudsen; F. Gustafsson; J. Toft; N. J. Christensen 1. We studied 37 healthy men at rest in the supine position to examine the effect of ageing, smoking and physical training on β 2 -adrenoceptor function, plasma catecholamines and the proportions of various lymphocyte subsets. 2. In 14 young...
Clin Sci (Lond) (1996) 91 (1): 107–111.
Published: 01 July 1996
.... Specific enzymes have a crucial role in these antioxidant defences, and their activity may be induced by regulatory mechanisms that respond to oxygen metabolite concentration. 2. To assess whether smoking induces an additional adaptive response, we compared antioxidant defence systems in erythrocytes from...
Clin Sci (Lond) (1995) 89 (4): 333–342.
Published: 01 October 1995
...Dilys J. Freeman; Chris J. Packard © 1995 The Biochemical Society and the Medical Research Society 1995 coronary heart disease lipoprotein metabolism smoking triacylgycerol Clinical Science (1995) 89, 333--342 (Printed in Great Britain) Editorial Review Smoking and plasma lipoprotein...
Clin Sci (Lond) (1994) 86 (3): 297–303.
Published: 01 March 1994
...Dr Peter Wilmshurst; Craig Davidson; Geraldine O'Connell; Christopher Byrne 1. Blind analysis of contrast echocardiograms to detect intracardiac shunts, blind analysis of lung function tests for evidence of small airways disease, smoking history and dive characteristics were examined in an attempt...
Clin Sci (Lond) (1993) 85 (1): 51–55.
Published: 01 July 1993
...Marie-Cécile Jacobs; Jacques W. M. Lenders; Jan A. Kapma; Paul Smits; Theo Thien 1. Cigarette smoking is one of the major risk factors for the development of atherosclerosis. It is not clear, however, whether chronic cigarette smoking impairs the normal physiological function of the endothelium...
Clin Sci (Lond) (1989) 76 (5): 487–494.
Published: 01 May 1989
...-asthmatic men who were never-smokers (aged 26-61 years) and in 41 male cigarette smokers (aged 32-64 years). The results were compared with those for spirometry and the single-breath N 2 test which are the most commonly used techniques in epidemiological surveys for detecting the effects of smoking on the...
Clin Sci (Lond) (1988) 75 (4): 371–373.
Published: 01 October 1988
...Andrew J. T. Kirkham; Andrew R. Guyatt; Gordon Cumming 1. The rise (‘boost’) in carboxyhaemoglobin (HbCO) on smoking has been studied with alveolar carbon monoxide measurements before and after smoking a cigarette. We re-examined this in 28 subjects with HbCO values compared with rebreathing carbon...
Clin Sci (Lond) (1988) 74 (1): 29–36.
Published: 01 January 1988
...Andrew R. Guyatt; Andrew J. T. Kirkham; Derek C. Mariner; Gordon Cumming 1. We measured alveolar carbon monoxide (CO) after a 20 s breath-holding period and carboxyhaemoglobin both before and after smoking a cigarette on 500 occasions (101 individuals). The two measurements were closely correlated...
Clin Sci (Lond) (1985) 68 (4): 395–399.
Published: 01 April 1985
... mothers than in group I, irrespective of smoking habits. There were no racial differences in peripheral white cell zinc levels. 4. PMN, and to a lesser degree MN, zinc levels were lower in smoking than in non-smoking mothers. 5. Erythrocyte zinc did not correlate with other zinc measurements nor with the...
Clin Sci (Lond) (1985) 68 (4): 419–425.
Published: 01 April 1985
... infarction is likely to be associated with a large mean platelet volume and low count compared with the ischaemic heart disease group. There is no statistical evidence that this condition is related to smoking or size and site of infarct. 5. This evidence suggests that large mean platelet volume and low...
Clin Sci (Lond) (1983) 65 (6): 661–664.
Published: 01 December 1983
...-smokers' (2.33 nmolh −1 μg −1 of DNA; sem 0.40) ( P <0.05). 4. AM from donors with a recent lower respiratory tract infection released increased quantities of H 2 O 2 (5.22 nmol h −1 μg −1 of DNA; sem 0.72; P <0.01) even when allowance was made for smoking habits. 5. These findings are consistent...
Clin Sci (Lond) (1983) 65 (6): 669–672.
Published: 01 December 1983
...-smokers there was a rise in the HDL 2 /HDL 3 cholesterol ratio after oral fat, but not in smokers. 4. These findings are compatible with the hypothesis that smoking interferes with the lipolysis of triglyceride rich lipoproteins and the conversion of HDL 3 into HDL 2 . 19 5 1983 18 7 1983...
Clin Sci (Lond) (1983) 64 (3): 273–280.
Published: 01 March 1983
... PRA in the pathogenesis of essential hypertension and target-organ damage. 19 7 1982 1 10 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 blood pressure hypertension ischaemic heart disease renin smoking Clinical Science (1983) 64,213-280 273 The...
Clin Sci (Lond) (1982) 63 (s8): 403s–405s.
Published: 01 October 1982
...S. Freestone; L. E. Ramsay 1. Patients with mild hypertension who habitually smoked cigarettes and consumed caffeine were examined after abstaining from caffeine and cigarettes overnight. Their mean blood pressure (147/89 mmHg) was substantially lower than values recorded in the clinic (164/102...