...Scott Earley; Joseph E. Brayden TRP (transient receptor potential) channels play important roles in the regulation of normal and pathological cellular function. In the vasculature, TRP channels are present both in ECs (endothelial cells) and vascular SMCs (smooth muscle cells) and contribute...

... commonly supposed with important receptor actions pre-junctionally as well as on the smooth muscle itself. The potential role of the pre-junctional M 2 receptor in the pathogenesis of asthma has been suggested before, supported by observation that viruses and eosinophils can suppress M 2 function (hence...

...Liming Jin; Arthur L. Burnett Penile erection is a complicated event involving the regulation of corpus cavernosal smooth muscle tone. Recently, the small monomeric G-protein RhoA and its downstream effector Rho-kinase have been proposed to be important players for mediating vasoconstriction...

... cerebral artery coronary artery 5-HT (5-hydroxytryptamine) receptor plasma concentration in vitro pharmacology smooth muscle triptan The drugs used currently that act as acute abortive anti-migraine therapies are defined as agonists at 5-HT 1B/1D receptors (where 5-HT is 5...

...Chia-Hung YEN; Ying-Tung LAU 17β-Oestradiol (E 2 ; oestrogen) is known to increase endothelium-dependent vasodilatation and NO (nitric oxide) production. It is also known to decrease the response of VSMCs (vascular smooth muscle cells) to vasoconstrictors in vitro . E 2 induces a decrease in age...

... paclitaxel, were implanted. The absorption and elution characteristics of paclitaxel were established. Artery tissue remained viable at 72h when cultured closed, despite stent implantation. Specimens developed smooth muscle cell proliferation. The stents absorbed up to 127±29 μ g of paclitaxel...

... oxide smooth muscle subcutaneous small arteries vascular structure 155Clinical Science (1999) 96, 155 163 (Printed in Great Britain) Altered small artery morphology and reactivity in critical limb ischaemia C. HILLIER, R. D. SAYERS*, P. A. C. WATT , R. NAYLOR , P. R. F. BELL and H. THURSTON...

... levels of α-smooth-muscle actin or proliferating cell nuclear antigen correlated with myosin heavy-chain levels in the glomeruli of rats with puromycin aminonucleoside nephrosis. None of the cellular components in the glomeruli was positive for either α-smooth-muscle actin or proliferating cell nuclear...

... 1987 autonomic regulation bronchial hyper-responsiveness heart-lung transplantation methacholine smooth muscle Clinical Science (1987) 73, 299-303 Bronchial hyper-responsiveness after human cardiopulmonary transplantation ALLAN R. GLANVILLE, eONOR M. BURKE, JAMES THEODORE, JOHN C. BALDWIN...

...A. F. Brading; J. L. Mostwin; G. N. A. Sibley; M. J. Speakman © 1986 The Biochemical Society and the Medical Research Society 1986 bladder intracellular potentials smooth muscle urethra Clinical Science (1986) 70 (Suppl. 14), 7s-13s 7s The role of smooth muscle and its possible...

... smooth muscle responsiveness to stimulation. Clinical Science( 1986) 70, 571-575 571 Effects of mucosal removal on guinea-pig airway smooth muscle responsiveness CHRISTOPHER MURLAS Pulmonary Divisions, Departments of Medicine, Physiology and Environmental Health, University of Cincinnati School...

...P. Leijten; C. Cauvin; N. Lodge; K. Saida; C. Van Breemen 1. We propose the following model of Ca 2+ mobilization by noradrenaline in vascular smooth muscle. Upon receptor occupation Ca 2+ from a labile small intracellular store on the inner plasmalemma is released. This Ca 2+ does not function...

...John C. McGrath 1. The effects of varying [Ca 2+ ] o on the contraction of smooth muscle by different α-adrenoceptor agonists were examined on rat isolated anococcygeus muscle. Agonists were tested in the presence of various [Ca 2+ ] o or ‘Ca 2+ -re-addition curves’ were constructed. In some...

... ORE. Key words: arterioles, calcium, forearm, nitro- prusside, smooth muscle, verapamil. Introduction A number of functional abnormalities have been demonstrated in the resistance vessels of patients with primary hypertension. Studies of the forearm vascular bed have revealed depression of the dilator...

... Vascular smooth muscle membrane potential and a ouabain- like humoral factor in one-kidney, one-clip hypertension in rats M O T I L A L B. P A M N A N I , D A V I D R . H A R D E R , S T E P H E N J . H U O T , H O W A R D J. B R Y A N T , F R A N C I S A. K U T Y N A A N D F R A N C I S J. H A D D Y...

...Yoshinori Kawaguchi; Kyuzo Aoki; Masahiko Yamamoto; Ken Hotta 1. Calcium reactivity of arterial smooth muscle and the effect of diltiazem (calcium antagonist) were investigated in helical strips of mesenteric arteries from 6-week-old male spontaneously hypertensive rats (SHR) and age-and sex...

... outside the normal range. 4. The abnormal pattern of response observed in the hypertensive group cannot be accounted for by structural changes in the vessels and strongly suggests a functional abnormality of the vascular smooth muscle. Clinical Science (1982) 63,33-42 33 Response of forearm resistance...

...R. Garcia; E. L. Schiffrin; G. Thibault; R. Boucher; J. Genest 1. The response of arterial smooth muscle to noradrenaline was studied in one-clip hypertensive rats with or without the contralateral/kidney and in normotensive rabbits. 2. Strips of aorta from one-kidney, one-clip hypertensive animals...

...S. N. Orlov; Yu. V. Postnov 1. The ability of isolated membrane fractions of cardiomyocytes, aortic smooth muscle and erythrocytes from spontaneously hypertensive rats to bind calcium was investigated isotopically. 2. Plasma membranes of aortic smooth muscle and erythrocytes of spontaneously...

... of noradrenaline into arterial tissue was similar in both groups, although uptake into the cephalic veins of deafferented animals was less than in the control group. 5. [ 3 H]Thymidine uptake, an index of DNA synthesis, was similar in both groups, radioautography revealing no difference in smooth muscle cell...

... therapeutic action in man. Propranolol has non-specific inhibitory effects on vascular smooth muscle, which might contribute to its hypotensive activity at high concentrations, but oxprenolol has only slight peripheral effects that are probably therapeutically insignificant. 23 12 1977 12 4 1978...

... AMP. © 1994 The Biochemical Society and the Medical Research Society 1994 angiotensin adenylcyclase phosphodiesterase cyclic AMP smooth muscle uterus Clinical Science and Molecular Medicine (1973) 45,247~250s. EFFECTS O F ANGIOTENSIN I1 O N ADENYLCYCLASE ACTIVITY, PHOSPHODIESTERASE...