... and is termed ‘metabolic memory’. SMCs (smooth muscle cells) of blood vessel walls, through their inherent ability to switch between a contractile quiescent phenotype and an active secretory state, maintain vascular homoeostasis in health and development. This plasticity also confers SMCs with the essential...

... coronary artery endothelial cells. However, the effect of Ang II and statin on leptin expression in VSMCs (vascular smooth muscle cells), the major cell types in atheroma, is poorly understood. Thus the aim of the present study was to investigate the molecular mechanism of atorvastatin for reducing leptin...

...Kou-Gi Shyu; Li-Ming Lien; Bao-Wei Wang; Peiliang Kuan; Hang Chang Resistin may play a major potential role in vascular remodelling and may contribute to atherogenesis. However, the role of VSMC (vascular smooth muscle cell)-derived resistin in neointimal formation is not well understood. We...

... sought to investigate the cellular and molecular mechanisms underlying the regulation of resistin by cyclic mechanical stretch in VSMCs (vascular smooth muscle cells). VSMCs from thoracic aorta of adult Wistar rats were cultured and subjected to cyclic stretch. Cyclic mechanical stretch significantly...

...Kou-Gi Shyu; Bao-Wei Wang; Hang Chang DDR2 (discoidin domain receptor 2) regulates collagen turnover mediated by SMCs (smooth muscle cells) in atherosclerosis. HBO (hyperbaric oxygen) has been used in medical practice; however, the molecular mechanism of the beneficial effects of HBO is poorly...

... healing and atherosclerotic lesion formation. Mechanical stretch can modulate several different cellular functions in VSMCs (vascular smooth muscle cells). These functions include, but are not limited to, cell alignment and differentiation, migration, survival or apoptosis, vascular remodelling...

..., as studies suggest that even imperfect base pairing of miRNA with its target mRNA can lead to a decrease in the abundance of the mRNA [ 37 , 38 ]. cardiac arrhythmia cardiac hypertrophy microRNA myocyte neointimal formation smooth muscle cell miRNAs (microRNAs) comprise a novel class...

.... 17 6 2003 9 7 2003 9 7 2003 © 2003 The Biochemical Society 2003 gene expression hypoxia-inducible factor-1 (HIF-1) mitogen-activated protein kinase (MAP kinase) smooth muscle cell stretch Clinical Science (2003) 105, 393 394 (Printed in Great Britain) 393 C O M M E N T...

...Hang CHANG; Kou-Gi SHYU; Bao-Wei WANG; Peiliang KUAN Vascular smooth muscle cells (VSMCs) are exposed to hormonal and mechanical stress in vivo . Hormonal factors have been shown to affect hypoxia-inducible factor-1α (HIF-1α). How mechanical stress affects the regulation of HIF-1α in VSMCs has...