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Articles
Clin Sci (Lond) (2019) 133 (6): 761.
Published: 19 March 2019
... 2019 09 02 2019 28 02 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 oedema sodium salt We would like to thank Dr Bhave for the provocative discussion and for providing further details on his theoretical framework...
Articles
Clin Sci (Lond) (2019) 133 (6): 739-740.
Published: 19 March 2019
... Portland Press Limited on behalf of the Biochemical Society 2019 Extracellular Matrix Sodium Tonicity I read with great interest the hypothesis paper by Rossitto et al [ 1 ]. The authors should be commended for a thoughtful analysis of the interpretation of changes in tissue [Na...
Articles
Clin Sci (Lond) (2018) 132 (24): 2609-2613.
Published: 13 December 2018
... distributed under the Creative Commons Attribution License 4.0 (CC BY) . concentration model MRI oedema sodium Classic physiology advocates the ultimate achievement of a constant balance between salt intake and excretion. At variance, over the last few years work by Titze and his...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (5): 415-422.
Published: 11 June 2015
... has been associated with higher mortality rates in people with diabetes. Our aim is to examine the effect of angiotensin II receptor blocker (ARB), telmisartan, with and without dietary sodium chloride (NaCl) supplementation, on BP [mean arterial pressure (MAP)], plasma renin activity (PRA), serum...
Articles
Clin Sci (Lond) (2009) 117 (1): 1-11.
Published: 02 June 2009
... human intervention studies demonstrate the association between salt intake and HBP. Furthermore, animal studies indicate that short-term interventions in humans may underestimate the health risks associated with high dietary sodium. Recent intervention studies have found decreases in cardiovascular...
Articles
Clin Sci (Lond) (2007) 113 (5): 251-258.
Published: 01 August 2007
...Linda S. Pescatello; Bruce E. Blanchard; Gregory J. Tsongalis; Carl M. Maresh; Ann O'Connell; Paul D. Thompson The α-adducin Gly460Trp polymorphism alters renal sodium transport and is associated with hypertension. Despite the immediate sodium- and volume-depleting effects of aerobic exercise, the...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 254S-257S.
Published: 01 September 2002
... prevented the reduction of urine flow rate and urinary sodium excretion in association with an increase in the glomerular filtration rate and renal plasma flow compared with the vehicle. FR901533 also suppressed significantly the elevation of plasma atrial natriuretic peptide and aldosterone levels which is...
Articles
Clin Sci (Lond) (2001) 101 (3): 243-251.
Published: 03 August 2001
... myocytes Na+/H+ exchange sodium 243Clinical Science (2001) 101, 243 251 (Printed in Great Britain) Importance of glycolytically derived ATP for Na+ loading via Na+/H+ exchange during metabolic inhibition in guinea pig ventricular myocytes Hiroshi SATOH, Shiho SUGIYAMA, Noriyuki NOMURA, Hajime TERADA...
Articles
Clin Sci (Lond) (2001) 100 (5): 557-566.
Published: 09 April 2001
...António FERREIRA; Paulo BETTENCOURT; Paula DIAS; Manuel PESTANA; Paula SERRÃO; Patrício SOARES-DA-SILVA; Mário CERQUEIRA-GOMES The benefits of tailoring therapy with vasodilators in patients with severe heart failure are well documented, but this may lead to neurohormonal activation and sodium...
Articles
Clin Sci (Lond) (2000) 98 (6): 697-702.
Published: 10 May 2000
... on oral contraceptives were enrolled; 17 were studied in the follicular phase and 18 in the luteal phase of the menstrual cycle. The women in each group were then randomly allocated to receive a low-sodium (40 mmol/day) or a high-sodium (250 mmol/day) diet for a 7-day period in two consecutive...
Articles
Clin Sci (Lond) (1998) 96 (1): 5-15.
Published: 01 January 1999
... increased from 1.6 to 101 ;pmol/l in control subjects and from 25 to 173 ;pmol/l in congestive heart failure during infusion. Urinary sodium excretion increased significantly in both congestive heart failure (60%) and control subjects (71%), but the absolute increase was significantly lower in congestive...
Articles
Clin Sci (Lond) (1998) 95 (5): 583-587.
Published: 01 November 1998
...Klaus KISTERS; Ernst-Rudolf KREFTING; Claus SPIEKER; Walter ZIDEK; Karl Heinz DIETL; Michael BARENBROCK; Karl Heinz RAHN 1. Although in blood cells decreased magnesium concentrations and increased sodium concentrations in essential hypertension have often been described, only sparse data exist on...
Articles
Clin Sci (Lond) (1998) 95 (1): 3-17.
Published: 01 July 1998
... ATPase catecholamines digitalis heart insulin muscle potassium sodium thyroid hormones training 3Clinical Science (1998) 95, 3 17 (Printed in Great Britain) + R E V I E W Clinical and therapeutic significance of the Na+,K+ pump* Torben CLAUSEN Department of Physiology, University of Aarhus...
Articles
Clin Sci (Lond) (1997) 93 (1): 35-41.
Published: 01 July 1997
... renal and cardiovascular damage. 7 2 1997 25 3 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 cardiovascular system endothelins endothelium hypertension sodium Clinical Science ( I 997) 93, 35-41 (Printed in Great Britain) 35 Elevated plasma and...
Articles
Clin Sci (Lond) (1997) 92 (4): 397-407.
Published: 01 April 1997
...JAN Carstens; Kaare T. Jensen; Erling B. Pedersen 1. The renal efficacy of urodilatin in humans has only been partly investigated. It is unknown whether intravenously infused urodilatin has an effect on sodium reabsorption in both the proximal and distal part of the nephron. 2. Twelve healthy...
Articles
Clin Sci (Lond) (1996) 91 (3): 299-305.
Published: 01 September 1996
...D. G. Shirley; S. J. Walter; R. J. Unwin 1. The nephron sites involved in the blunted natriuretic response to frusemide during sodium depletion were investigated using micropuncture techniques in anaesthetized rats. 2. Glomerular filtration rate was lower, and fractional sodium reabsorption in the...
Articles
Clin Sci (Lond) (1995) 89 (3): 293-298.
Published: 01 September 1995
... gradients, and a Na + -Mg 2+ exchanger may be involved in the regulation of [Mg 2+ ] i in human platelets. 14 3 1995 24 4 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 cytosolic magnesium mag-fura-2 ouabain sodium Clinical Science (1995) 89, 293-298...
Articles
Clin Sci (Lond) (1995) 88 (3): 293-299.
Published: 01 March 1995
...Eric Féraille; Sophie Marsy; Catherine Barlet-Bas; Martine Rousselot; Lydie Cheval; Herve Favre; Alain Doucet 1. Hyperinsulinaemia is considered to be a pathogenic factor for human and experimental hypertension. Thus, the contribution of the known insulin-stimulated tubular sodium reabsorption to...
Articles
Clin Sci (Lond) (1994) 87 (4): 447-451.
Published: 01 October 1994
... Medical Research Society 1994 digoxin-like substances oxygen respiratory disease sodium Clinical Science (1994) 87, 447451 (Printed in Great Britain) 447 Plasma endogenous digoxiwlike substance levels are dependent on blood 0, in man Claudio FERRI, Cesare BELLINI, Simonetta COASSIN, Claudio DE...
Articles
Clin Sci (Lond) (1994) 86 (5): 575-581.
Published: 01 May 1994
... pre-eclampsia by intravenous frusemide, which stimulates renin acutely through a prostacyclin-mediated mechanism. 2. Plasma active renin concentration, plasma aldosterone concentration, haematocrit and urinary sodium, creatinine and 6-keto-prostaglandin F 1α were measured before (0) and 15, 30 and 60...
Articles
Clin Sci (Lond) (1994) 86 (4): 383-390.
Published: 01 April 1994
...Carlo Beretta-Piccoli; Francesca Elshater-Zanetti; Sidney Shaw; Daniele Cusi; Peter Weidmann 1. Diabetes mellitus is associated with high body sodium, but the pathogenetic mechanism is still unknown. The possibility that an abnormal renal handling of sodium, an abnormal responsiveness of sodium...
Articles
Clin Sci (Lond) (1994) 86 (3): 353-357.
Published: 01 March 1994
... Research Society 1994 absorption chloride diuretics oxalate secretion sodium Clinical Science (1994) 86, 353-357 (Printed in Great Britain) Do thiazides reduce intestinal oxalate absorption?: a study in vitro using rabbit colon M. HATCH and N. D. VAZlRl Division of Nephrology, Department of...
Articles
Clin Sci (Lond) (1994) 86 (1): 1-9.
Published: 01 January 1994
...Nigel D.C. Sturrock; A.D. Struthers © 1994 The Biochemical Society and the Medical Research Society 1994 calcium cyclosporin hypertension nephrotoxicity prostaglandins renin-angiotensin system sodium Clinical Science (1994) 86, 1-9 (Printed in Great Britain) I Editorial Review...
Articles
Clin Sci (Lond) (1993) 85 (1): 13-17.
Published: 01 July 1993
...G. A. Sagnella; N. D. Markandu; M. G. Buckley; D. R. J. Singer; G. A. MacGregor 1. The present study was designed to investigate the relationships between circulating atrial natriuretic peptide, plasma and urinary cyclic GMP and sodium excretion under basal conditions and in response to changes in...
Articles
Clin Sci (Lond) (1993) 84 (4): 357-375.
Published: 01 April 1993
... dopaminergic agonists of therapeutic utility. 7. Final conclusions and unanswered questions. © 1993 The Biochemical Society and the Medical Research Society 1993 dopamine hypertension kidney sodium Clinical Science (1993) 81, 357-375 (Printed in Great Britain) 357 Editorial Review Dopamine and...
Articles
Clin Sci (Lond) (1993) 84 (4): 401-405.
Published: 01 April 1993
... + -K + pump rate constant during the menstrual cycle. 23 10 1992 25 11 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 adenosine triphosphatase erythrocytes menstrual cycle potassium pregnancy sodium sodium-potassium pump Clinical Science (1993...
Articles
Clin Sci (Lond) (1993) 84 (2): 237-242.
Published: 01 February 1993
... baseline period and three 1 h periods during dopamine infusion. 2. Baseline sodium clearance with placebo was 0.65 ± 0.35 ml/min, but with lithium it increased to 1.25 ± 0.44 ( P < 0.001) and 1.17 ± 0.46 ml/min ( P < 0.01) after 450 and 600 mg, respectively. Urine flow rates were unchanged compared...
Articles
Clin Sci (Lond) (1992) 83 (3): 301-306.
Published: 01 September 1992
... stimulation of prostacyclin synthesis during Na + deprivation could impair Na + conservation. 23 3 1992 8 6 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 ageing prostacyclin prostaglandin E 2. renal papilla sodium thromboxane Clinical Science (1992...
Articles
Clin Sci (Lond) (1992) 82 (4): 341-352.
Published: 01 April 1992
...P. A. Rutherford; T. H. Thomas; R. Wilkinson © 1992 The Biochemical Society and the Medical Research Society 1992 diabetes mellitus erythrocyte hyperlipidaemia hypertension lithium pregnancy sodium Clinical Science (1992) 82, 341-352 (Printed in Great Britain) Editorial Review 34...
Articles
Clin Sci (Lond) (1992) 82 (3): 291-299.
Published: 01 March 1992
...Peter A. Rutherford; Trevor H. Thomas; Susan J. Carr; Roy Taylor; Robert Wllklnson 1. Increased erythrocyte sodium-lithium countertransport activity has been reported to be associated with nephropathy in type 1 diabetes and linked to a family history of essential hypertension. 2. This study aimed...
Articles
Clin Sci (Lond) (1992) 82 (1): 99-104.
Published: 01 January 1992
...J. F. St. J. Dwight; A. C. Mendes Ribeiro; B. M. Hendry 1. Sodium pump function has been assessed by measurement of ouabain-sensitive 86 Rb uptake in human erythrocytes after incorporation of palmitic, stearic, oleic and linoleic acids into the erythrocyte membrane. 14 C-labelled fatty acids were...
Articles
Clin Sci (Lond) (1991) 80 (6): 599-604.
Published: 01 June 1991
...B. Vogt; H. Favre 1. In the nephrotic syndrome the kidneys retain salt and water, which leads to oedema formation. The site of this sodium retention has been localized in the cortical collecting tubule by micropuncture studies. Whether or not this phenomenon is an intrinsic renal problem or is the...
Articles
Clin Sci (Lond) (1991) 80 (2): 95-99.
Published: 01 February 1991
..., although in vivo the presence of HCO − 3 /Cl − exchangers may also contribute to intracellular pH homoeostasis. 7 8 1990 16 8 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 amiloride leucocytes pH sodium Clinical Science ( 199 1 ) 80, 95-99 95 Na+/H...
Articles
Clin Sci (Lond) (1990) 79 (6): 631-638.
Published: 01 December 1990
...S. MacPhail; T. H. Thomas; R. Wilkinson; J. M. Davison; W. Dunlop 1. Normotensive primigravid pregnant women were studied longitudinally during pregnancy and 20 weeks after delivery. 2. Erythrocyte sodium content, ouabain-sensitive sodium flux and sodium pump rate constant were measured in whole...
Articles
Clin Sci (Lond) (1990) 79 (5): 505-511.
Published: 01 November 1990
... sodium Clinical Science (1990) 79, 505-51 1 505 Stimulation of active renin release in normal and hypertensive pregnancy MARK A. BROWN, VIVIENNE C. ZAMMIT AND DELMA ADSETT Department of Renal Medicine, St George Hospital, Kogarah, New South Wales, Australia (Received 12 March/l4 May 1990; accepted 6...
Articles
Clin Sci (Lond) (1990) 79 (5): 491-497.
Published: 01 November 1990
... 1990 19 6 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 hypertension leucocyte muscle nuclear magnetic resonance protons sodium Clinical Science ( 1 990) 79,491-497 49 1 Evidence for abnormal Na+ /H + antiport activity detected by phosphorus nuclear...
Articles
Clin Sci (Lond) (1990) 79 (4): 315-323.
Published: 01 October 1990
...Alan J. Knox; Paul Ajao; John R. Britton; Anne E. Tattersfield 1. To determine whether alterations in membrane sodium transport in airway smooth muscle can alter its contractility, we studied the effect of ouabain (a Na + /K + -adenosine triphosphatase inhibitor) and amiloride on contractile...
Articles
Clin Sci (Lond) (1990) 78 (6): 605-612.
Published: 01 June 1990
...D. J. S. Carmichael; M. S. Sutters; R. J. Unwin; D. Gordon; J. Few; V. H. T. James; J. Wadsworth; W. S. Peart 1. The fall in renal sodium excretion after dietary sodium restriction is prompt and reproducible. The importance of increased aldosterone secretion during the early phase (within 48 h) of...
Articles
Clin Sci (Lond) (1990) 78 (5): 503-507.
Published: 01 May 1990
...N. V. Olsen; J. M. Hansen; S. D. Ladefoged; N. Fogh-Andersen; P. P. Leyssac 1. Using the renal clearance of lithium ( C Li ) as an index of proximal tubular outflow of sodium and water, together with simultaneous measurements of effective renal plasma flow, glomerular filtration rate (GFR) and...
Articles
Clin Sci (Lond) (1990) 78 (5): 497-501.
Published: 01 May 1990
... tubuloglomerular feedback activity. 2. Glomerular function and the renal tubular handling of sodium during infusion of amino acids was studied in 12 normal volunteers. 3. Clearance of sodium ( C Na ) was unchanged. Effective renal plasma flow increased slightly, but significantly, by 9% ( P <0.05). GFR was...
Articles
Clin Sci (Lond) (1990) 78 (4): 423-429.
Published: 01 April 1990
... Society 1990 denervation dopa dopamine natriuresis salt sodium Clinical Science (1990) 78,423-429 423 Increased spillover of dopa into arterial blood during dietary salt loading EHUD GROSSMAN', AARON HOFFMAN', PETER C. CHANG', HARRY R. KEISER' AND DAVID S. GOLDSTEIN' 'Hypertension-Endocrine...
Articles
Clin Sci (Lond) (1990) 78 (3): 335-341.
Published: 01 March 1990
... min −1 and a saturable component with a K m of 61 ± 23 μmol/l and a V max. of 11.3 ± 4.5 × 10 −4 mmol min −1 l −1 . Ouabain and low extracellular concentrations of sodium partly inhibited influx. Uptake was predominantly into the cytosolic fraction of the cell with 12% entering the membrane-associated...
Articles
Clin Sci (Lond) (1990) 78 (2): 235-238.
Published: 01 February 1990
...J. Main; T. Thomas 1. Although ethanol appears to alter cellular sodium transport, the exact nature of its effects has not been clearly defined. We have studied the effects of different concentrations of ethanol on human leucocyte sodium content, and on the rise in leucocyte sodium content which...
Articles
Clin Sci (Lond) (1989) 77 (4): 417-423.
Published: 01 October 1989
... Biochemical Society and the Medical Research Society 1989 amiloride leucocytes sodium Clinical Science ( 1989) 77, 41 7-423 417 Intracellular pH clamping of human leucocytes: a technique for determination of cellular buffering power and Na+/H+ antiport characteristics L. L. NG AND C . DUDLEY Sheikh...
Articles
Clin Sci (Lond) (1989) 77 (2): 157-160.
Published: 01 August 1989
...J. Main; T. H. Thomas; R. Wilkinson 1. Previous published measurements of leucocyte cation content are inconsistent, with sodium concentrations having particularly high coefficients of variation. We have measured the effects of recovery time after isolation, different types of handling, and...
Articles
Clin Sci (Lond) (1989) 76 (5): 469-474.
Published: 01 May 1989
... Society 1989 angiotensin II prostaglandin E 2 prostaglandin F 2α prostaglandin I 2 sodium thromboxane Clinical Science (1989) 76,469-474 469 Effects of sodium depletion on renal prostanoid synthesis in rats: influence of the converting enzyme inhibitor captopril M. RATHAUS, E. PODJARNY, A...
Articles
Clin Sci (Lond) (1989) 76 (2): 157-163.
Published: 01 February 1989
... to be markers of secondary hypertension in these patients. 15 6 1988 22 6 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 chronic renal failure co-transport countertransport endogenous digoxin-like immunoreactivity natriuretic hormone sodium...
Articles
Clin Sci (Lond) (1989) 76 (2): 199-203.
Published: 01 February 1989
...R. Seon; T. Forrester 1. One hundred and five primigravidae were followed sequentially at 4-weekly intervals starting at gestational week 31. They were seen again at 6 weeks post partum . 2. At each visit measurements were made of blood pressure as well as of leucocyte and erythrocyte sodium and...
Articles
Clin Sci (Lond) (1988) 75 (5): 521-526.
Published: 01 November 1988
... measured in media containing 10 mmol/l Na + and that this is contributed mainly by amiloride-sensitive and bumetanide-sensitive Na + influx mechanisms. 8 4 1988 27 4 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 amiloride hypertension leucocytes sodium...
Articles
Clin Sci (Lond) (1988) 75 (4): 403-410.
Published: 01 October 1988
... tubular function. 2. hANP increased urine flow rate, sodium, calcium and magnesium excretion without significant changes in potassium and phosphate excretion, heart rate or blood pressure. 3. hANP caused a small change in fractional lithium clearance, and larger changes in distal nephron handling of...