... reabsorption 195Clinical Science (2001) 101, 195 198 (Printed in Great Britain) + R A P I D C O M M U N I C A T I O N In vivo inhibition of renal 11b-hydroxysteroid dehydrogenase in the rat stimulates collecting duct sodium reabsorption M. A. BAILEY, R. J. UNWIN and D. G. SHIRLEY Centre for Nephrology...

...R. J. UNWIN; S. J. WALTER; G. GIEBISCH; G. CAPASSO; D. G. SHIRLEY In order to clarify the effects on sodium reabsorption in the loop of Henle of methazolamide (a carbonic anhydrase inhibitor), chlorothiazide and the loop diuretics frusemide and bumetanide, superficial loops were perfused in vivo...

... acidosis, kinetics of tubular acidification, lithium, sodium reabsorption. Correspondence: Dr M. Mello Aires, Departamento de Fisiologia e BioEisica, lnstituto de CiCncias BiomCdicas, Universidade de Sio Paulo, Siio Paulo, SP, Brasil Abbreviations: DCT, distal convoluted tubule; Hepes, 4-( 2-hydroxyethy1...

..., the increase in intra- ureteral pressure in the upright and supine posi- tions and the effect of the so-called arteriovenous shunt through the newly formed uterine vessels [45] might all be expected to influence the final sodium reabsorption. Added to these are the effects of posture. Although the upright...

...), but did not correlate with the change in sodium excretion. 4. The exaggerated natriuresis was accompanied by a significant rise in the absolute rate of sodium reabsorption in the distal segments, but distal fractional reabsorption decreased. 5. It is concluded that the exaggerated natriuresis can...

... are unaffected by unilateral nephrectomy and suggest that, in the remaining kidney, atrate reabsorption along the entire nephron increases in proportion to the increment in glomerular filtration. Key words : concentration, dilution, kidney function, sodium reabsorption, uninephrectomy. Correspondence: Dr Adrian...

...) concentration rose progressively with the increasing concentration of the saline solution infused. 2. The greater fractional sodium excretion (FE Na ) after acute isotonic and hypertonic volume expansion is probably the result of inhibition of sodium reabsorption in the collecting duct, although inhibition...