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Keywords: somatostatin
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Clin Sci (Lond) (1993) 85 (5): 615–621.
Published: 01 November 1993
... pathogenic role of reactive oxygen species and to elucidate a possible therapeutic role for somatostatin. 2. Mild pancreatitis was induced by low blockade of the biliary duct and severe pancreatitis was evoked by retrograde infusion of bile salts. Renal function was studied by clearance techniques in rats...
Clin Sci (Lond) (1993) 84 (4): 455–460.
Published: 01 April 1993
...Cheryl Ray; Shane Carney; Trefor Morgan; Alastair Gillies 1. Experiments in vivo and in vitro were performed in the rat to define the role of somatostatin in modulating the hydro-osmotic action of arginine vasopressin. 2. Somatostatin had a biphasic effect on basal collecting duct diffusional water...
Clin Sci (Lond) (1992) 83 (5): 575–581.
Published: 01 November 1992
...Martin Muntzel; Thierry Hannedouche; Roberte Niesor; Laure-Helène Nöel; Jean-Claude Souberbielle; Bernard Lacour; Tilman Drüeke 1. To determine whether treatment with octreotide, a somatostatin analogue, may diminish or prevent long-term diabetic renal hypertrophy and nephropathy, uninephrectomized...
Clin Sci (Lond) (1989) 77 (6): 623–628.
Published: 01 December 1989
...S. J. Raimbach; P. Cortelli; J. S. Kooner; R. Bannister; S. R. Bloom; C. J. Mathias 1. The haemodynamic and hormonal changes following glucose ingestion (1 g/kg) were determined before and after pretreatment with either placebo or the somatostatin analogue, octreotide (SMS 201-995, 50 μg sub...
Clin Sci (Lond) (1988) 75 (4): 345–350.
Published: 01 October 1988
...Niels MøLler; Guyla Petrany; David Cassidy; William L. Sheldon; Desmond G. Johnston; Michael F. Laker 1. Somatostatin analogues, such as SMS 201–995 (sandostatin), have been suggested as treatment for a variety of disease states including acromegaly, secretory gastrointestinal tumours and diabetes...
Clin Sci (Lond) (1986) 70 (6): 547–554.
Published: 01 June 1986
...D. L. Maxwell; K. B. Nolop; J. M. B. Hughes 1. In seven normal subjects the ventilatory responses to progressive isocapnic hypoxia and hyperoxic hypercapnia were measured during rebreathing. 2. During an infusion of somatostatin (10 nmol/mm) the mean hypoxic response decreased by 66% (control...
Clin Sci (Lond) (1983) 65 (5): 491–498.
Published: 01 November 1983
... infusion of either leucine (300 μmol/min for 150 min, series A), or leucine plus glucose (2.2 mmol/min, series B), or leucine, somatostatin (7 μg/min) and glucagon (1 ng/min, series C). Arterial concentrations of substrates and their net exchange across the splanchnic and leg tissues were determined...
Clin Sci (Lond) (1981) 61 (6): 785–787.
Published: 01 December 1981
...H.-G. Güllner; Virginia Harris; R. H. Unger 1. the effect of the tachykinin dodecapeptide kassinin, which has been extracted from the skin of several African frogs, on somatostatin release was examined in the rat and compared with that of the neuropeptide substance P. 2. Equimolar doses of the two...
Clin Sci (Lond) (1981) 61 (5): 653–656.
Published: 01 November 1981
...A. J. Barnes; R. G. Long; T. E. Adrian; W. Vale; M. R. Brown; J. E. Rivier; J. Hanley; M. A. Ghatei; D. L. Sarson; S. R. Bloom 1. The biochemical specificity and duration of action of a single 5 mg subcutaneous dose of des-AA 1,2,4,5,12,13 - d -Trp 8 -somatostatin were evaluated in eight patients...
Clin Sci (Lond) (1980) 58 (4): 317–320.
Published: 01 April 1980
...P. Laurberg 1. This study has evaluated the effect of somatostatin (0.1 or 3 μg/ml) on the release of thyroxine, 3,5,3′-tri-iodothyronine and 3,3′,5′-tri-iodothyronine from perfused thyroid lobes. 2. Somatostatin did not affect either the total release of iodothyronines or the ratio between various...