...Seiya Okuda; Hiroshi Tsuruda; Kaoru Onoyama; Yukinori Oh; Kenichi Motomura; Masatoshi Fujishima 1. Effect of hypertension on progressive renal disease was examined in spontaneously hypertensive rats (SHR) with experimental focal glomerular sclerosis, produced by the intravenous administration...

...R. Clinton Webb 1. The effect of the hypertensive process on vascular sensitivity to serotonin and methysergide was studied. 2. Isometric contractions were recorded from arteries isolated from spontaneously hypertensive (SHR), Kyoto-Wistar normotensive (WKY), deoxycorticosterone acetate (DOCA...

...D. Trachewsky; D. C. Kem 1. Riboflavin analogues were tested in three hypertensive rat models: the DOCA-salt hypertensive rat, spontaneously hypertensive rats (SHR) and Dahl S rats. 2. When 1.6 mg of 7,8-dimethyl-10-formyl-methylisoalloxazine (FMI) or 7,8-dimethyl-10-(2′-hydroxyethyl)isoalloxazine...

...H. A. J. Struyker-Boudier; R. T. Evenwel; J. F. M. Smits; H. Van Essen 1. Baroreflex sensitivity was studied in relation to the development of spontaneous hypertension in rats (SH rats), with normotensive Wistar-Kyoto (WKY) rats as controls. Conscious, freely moving animals were studied...

...Anna Palermo; Carlo Costantini; Gabriele Mara; Arnaldo Libretti 1. There is evidence that dysfunction of central adrenergic neurons and the peripheral sympathetic nervous system are implicated in the development and maintenance of spontaneous hypertension. 2. Accordingly adrenoceptors of brain...

...M. J. Mulvany; N. Nyborg; H. Nilsson 1. We have investigated the noradrenaline-activated calcium sensitivity of 150 μm mesenteric resistance blood vessels from spontaneously hypertensive and control Wistar-Kyoto rats. 2. Under control conditions the spontaneously hypertensive rat blood vessels had...

...M. A. Saragoca; R. C. Tarazi 1. In response to graded infusions of isoprenaline, adult spontaneously hypertensive rats (20-24 weeks old) showed diminished responses of left ventricular contractile indices, diminished chronotropic responses and impairment of left ventricular relaxation rate...

... low renin, presumably volume-expanded forms of hypertension. 3. By contrast, pump suppression does not appear to be involved in spontaneously hypertensive rats or in salt-induced hypertension in Dahl's salt-sensitive rats. In these genetic models the primary defect may be increased cell membrane...

...Kim Hanh Le Quan-Bui; Jean-Luc Elghozi; Marie-Aude Devynck; Philippe Meyer 1. The noradrenaline content of individual brain nuclei was measured by using high-pressure liquid chromatography coupled with electrochemical detection. 2. This study was performed on spontaneously hypertensive rats during...

...A. R. Sinaiko; M. J. Cooper; B. L. Mirkin 1. Chemical sympathectomy was produced in spontaneously hypertensive rats by intraperitoneal injection of 6-hydroxydopamine hydrobromide (6-OHD) (100 μg/g body weight) on days 1, 4 and 7 of neonatal life and weekly thereafter until 6 weeks of age. The dose...

...M. J. Mulvany; C. Aalkjær; J. Christensen 1. We have compared the noradrenaline sensitivity of 150 μm arterial resistance vessels taken from a specific place in the mesenteric bed of spontaneously hypertensive (SH) rats and of control Wistar—Kyoto (WK) rats at three ages: 6 weeks, 12 weeks and 24...

... 7 9 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 glomerular filtration haemodynamics renal arteriolar resistances salt hypertension spontaneous hypertension Clinical Science (1979) 56,203-209 Regulation of glomerular capillary pressure and filtration...

... spontaneously hypertensive rats, but in older spontaneously hypertensive rats arterial wall renin was significantly increased and renal venous renin was significantly decreased. 3. Arterial wall renin in rats with either acute or chronic two-kidney Goldblatt renal hypertension was significantly increased...

...Michael G. Collis; Paul M. Vanhoutte 1. Vascular reactivity was studied in Tyrode solution perfused kidneys from young (7 weeks) and mature (4–6 months) spontaneously hypertensive rats (SH rats). 2. The response to nerve stimulation was greater in the kidneys from young SH rats than in those from...

...Jan Möhring; Jacqueline Kintz; Josiane Schoun 1. The role of arginine—vasopressin (AVP) and of angiotensin in blood pressure control of spontaneously hypertensive rats (SH rats, stroke-prone strain) was studied. 2. In SH rats, which drank water or 1% NaCl, plasma AVP concentrations were elevated...

...C. M. Markov 1. Biosynthesis of PGE 2 from [ 14 C]arachidonic acid has been found to be lower and PGF 2α higher in the renal medulla of spontaneously hypertensive (SH) rats than in normal Wistar (NW) rats. 2. Biosynthesis of prostacyclin (PGF 1α ) from [ 14 C]arachidonic acid was decreased in lungs...

...YU. V. Postnov; S. N. Orlov; P. V. Gulak; A. S. Shevchenko 1. Erythrocyte membrane permeability to sodium and potassium ions was studied in 8–10 weeks spontaneously hypertensive rats (SHR, Kyoto/Wistar strain), normotensive Wistar and Sprague—Dawley rats. 2. The rate of 22 Na efflux from...

...N. Saito; S. Mukaino; K. Ogino; C. Kawai 1. Renal and cerebral vascular lesions occurred more often and earlier in spontaneously hypertensive rats (SHR) given a high salt diet than in SHR given a normal diet. 2. Kidney renin activity was low during high salt loading; the kidney renin activity...

... concentrations than transplantation of kidneys from NR donors. 5 5 1974 © 1974 The Biochemical Society and the Medical Research Society 1974 spontaneous hypertension renal transplant Clinical Science and Molecular Medicine (1974) 47,435-448. BLOOD PRESSURE CHANGES PRODUCED BY KIDNEY CROSS...

...Hideo Ueda 1. High-salt, high-carbohydrate and low-protein diet induces remarkable elevation of blood pressure in spontaneous hypertensive rats (SHR). 2. These animals have low serum potassium, low blood urea nitrogen and high blood sugar. 3. Heart weight is increased in proportion to the elevation...

...B. Folkow; Margareta Hallbäck; Lilian Weiss 1. The hypothalamic defence reaction was assessed in spontaneously hypertensive rats (SHR) and normotensive control rats (NCR). 2. SHR exhibited an apparently true hyper-reactivity of central autonomic structures mediating emotional behaviour during...

...G. Bianchi; U. Fox; G. F. Di Francesco; U. Bardi; Maria Radice 1. Spontaneously hypertensive and normotensive rats were selectively bred from a single Wistar strain. 2. Cross-transplantation of kidneys from hypertensive to normotensive rats and vice versa was performed, the sole remaining kidney...

... Society and the Medical Research Society 1994 spontaneous hypertension thymus autoimmunity Clinical Science and Molecular Medicine (1973) 45, 141s-144s. THE THYMUS OF SPONTANEOUSLY HYPERTENSIVE RATS: LIGHT- A N D ELECTRON-MICROSCOPIC STUDIES J . M. R O J O - O R T E G A , E. Y E G H I A Y A N...