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1-28 of 28
Keywords: spontaneously hypertensive rat
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Articles
Jan Neckář, Md. Abdul Hye Khan, Garrett J. Gross, Michaela Cyprová, Jaroslav Hrdlička, Alena Kvasilová, John R. Falck, William B. Campbell, Lenka Sedláková, Šárka Škutová, Veronika Olejníčková, Martina Gregorovičová, David Sedmera, František Kolář, John D. Imig
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (8): 939–951.
Published: 29 April 2019
...) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p.o., 9...
Articles
José M. González, Beatriz Somoza, M. Victoria Conde, Maria S. Fernández-Alfonso, M. Carmen González, Silvia M. Arribas
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (10): 651–659.
Published: 14 April 2008
...José M. González; Beatriz Somoza; M. Victoria Conde; Maria S. Fernández-Alfonso; M. Carmen González; Silvia M. Arribas The present study explores the contribution of alterations in resting tone to cerebral artery narrowing in SHRs (spontaneously hypertensive rats) and the role of hypertension...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (5): 541–546.
Published: 01 May 2004
...-related BP (blood pressure) development in MSHR (male spontaneously hypertensive rats). Whether this decrease is due to an effect on the endothelium or smooth muscle is unknown. To determine this effect, we examined the role of E 2 on vascular endothelium and smooth muscle separately. We treated MSHR...
Articles
Virginia CHAMORRO, Rosemary WANGENSTEEN, Juan SAINZ, Juan DUARTE, Francisco O'VALLE, Antonio OSUNA, Félix VARGAS
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (3): 251–259.
Published: 01 March 2004
... hypertrophy and renal injury in spontaneously hypertensive rats (SHRs), and explores how these effects are modified when spontaneous hypertension is transformed in a low-renin model by the administration of deoxycorticosterone acetate (DOCA). The following groups were used: SHR-control, SHR+DOCA, SHR+losartan...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (2): 163–171.
Published: 01 February 2004
...Jennifer M. HUGHES; Stuart J. BUND In the present study, myogenic properties of femoral arteries from control hindlimbs and those distal to external iliac artery partial ligation of spontaneously hypertensive rats (SHRs) and normotensive Wistar–Kyoto (WKY) rats were assessed. Arterial pressure...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (4): 385–393.
Published: 14 September 2001
...Stuart J. BUND This investigation related arterial structure to myogenic (pressure-dependent) contractile responses in resistance arteries from spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) normotensive control rats under pressurized conditions in vitro . Femoral and mesenteric...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (4): 277–283.
Published: 01 September 2000
... Balfagón (e-mail [email protected] ). 4 1 2000 29 3 2000 2 6 2000 The Biochemical Society and the Medical Research Society © 2000 2000 electrical field stimulation nitrergic innervation protein kinase C rat mesenteric artery spontaneously hypertensive rat...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (3): 277–282.
Published: 09 February 2000
... in anaesthetized spontaneously hypertensive rats (SHR). Miconazole, a non-selective inhibitor of CYP-450 that inhibits both hydroxylation and epoxidation, substantially suppressed mesenteric vasoconstrictor responses to angiotensin II in SHR, but had no effect on responses to noradrenaline or sympathetic nerve...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (2): 239–246.
Published: 29 June 1999
...-old male spontaneously hypertensive rats (SHR 12 and SHR 20 respectively) and age-matched Wistar–Kyoto rats (WKY 12 and WKY 20 respectively). These rats were killed after measurement of haemodynamic parameters by transthoracic echocardiography and use of a tipmanometer via the right carotid artery...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (3): 303–309.
Published: 01 September 1998
... accordingly. Correspondence : Dr Sven-Olof Granstam. 5 1 1998 18 3 1998 14 4 1998 The Biochemical Society and the Medical Research Society © 1998 1998 acetylcholine blood flow carvedilol haemodynamics hypertension spontaneously hypertensive rat 303Clinical Science...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (3): 231–238.
Published: 01 March 1998
...Stuart J. Bund 1. Endothelium-dependent acetylcholine-mediated relaxations of small coronary arteries (∼200 μm internal diameter) from 20 weeks old spontaneously hypertensive rats (SHR) and normotensive Wistar—Kyoto (WKY) controls were compared under pressurized no-flow conditions after...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (3): 225–229.
Published: 01 March 1998
...Susana R. Garcia; Stuart J. Bund 1. The endothelium contributes substantially to the modulation of myogenic tone in coronary arteries from spontaneously hypertensive rats (SHR) and Wistar—Kyoto rats (WKY). This study has addressed the contributions of endothelium-derived nitric oxide and cyclo...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (6): 719–725.
Published: 01 June 1995
... in hypertensive strains are scarce. 2. We studied the effects of 27 weeks of a fructose-versus a corn-starch-enriched (69.5% w/w) diet in the spontaneously hypertensive rat. 3. In both dietary groups, blood pressure increased with ageing, with no apparent difference between the diets. The fructose-fed rats gained...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (1): 1–4.
Published: 01 July 1994
...Michael A. Kaiser; David Lodwick; Nilesh J. Samani 1. S A is a recently identified gene implicated in blood pressure regulation in rodent models of genetic hypertension. In this study we have examined, by Northern blotting, its expression in tissues of the spontaneously hypertensive rat, the Wistar...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (5): 585–591.
Published: 01 November 1993
...Robert I Norman; Navtej Achall 1. The relationships between systolic blood pressure and altered erythrocyte Ca 2+ -Mg 2+ -ATPase activity and membrane microviscosity were assessed in membranes prepared from 20-week-old female Wistar-Kyoto normotensive and spontaneously hypertensive rats obtained...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 491–497.
Published: 01 October 1991
.... The production of prostaglandin E 2 , 6-keto-prostaglandin F 1α and thromboxane B 2 was greater by glomeruli from untreated spontaneous hypertensive rats (prostaglandin E 2 2.24 ± 0.41, 6-keto-prostaglandin F 1α 1.20 ± 0.13 and thromboxane B 2 2.75 ± 0.43 ng 10 min −1 mg −1 of protein) than by those from Wistar...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (3): 321–327.
Published: 01 March 1987
...A. Louise Sugden; Barbara L. Bean; James A. Straw 1. These studies were designed to investigate the effects of high dietary K + on electrolyte and water balance in young spontaneously hypertensive rats (SHR) and to relate these effects to changes in blood pressure. 2. The high K + diet reduced...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (3): 271–275.
Published: 01 March 1987
...Jaroslav Kunes; Stephen C. Pang; Marc Cantin; Jacques Genest; P. Hamet 1. Cardiac hyperplasia in newborn spontaneously hypertensive rats (SHR) has been noted by our group as well as by other investigators. The present study was designed to establish whether early (neonatal) hyperplasia is confined...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (3): 313–319.
Published: 01 March 1987
...A. Louise Sugden; James A. Straw; Barbara L. Bean 1. Blood pressure was measured after treatment with a high K + , a low Na + and a combined high K + /low Na + diet in young spontaneously hypertensive rats (SHR). 2. A high K + diet reduced blood pressure by approximately 10 mmHg during...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (4): 407–410.
Published: 01 April 1985
...J. Higaki; T. Ogihara; Y. Kumahara; E. L. Bravo 1. Intracellular calmodulin levels were measured by direct radioimmunoassay in spontaneously hypertensive rats (SHR) and Wistar—Kyoto rats (WKY). 2. Decreased calmodulin levels were demonstrated in the brain, heart, aorta and kidney of spontaneously...
Articles
Inès Aragon, Thérèse Montenay-Garestier, Marie-Aude Nunez, Marie-Gabrielle Pernollet, Anne-Marie Nunez, Drori Ben-Ishay, Philippe Meyer, Claude Helene
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 49s–52s.
Published: 01 October 1982
... plasma membrane spontaneously hypertensive rat Clinical Science (1982) 63,49~-52s 49s Diffuse structural abnormalities in cell membranes from genetically hypertensive rats: a fluorescence polarization study INES ARAGON*t, THBRESE MONTENAY-GARESTIER?, MARIE-AUDE DEVYNCK*, PHILIPPE MEYER A N D CLAUDE...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (6): 685–691.
Published: 01 December 1981
...M. Bianchi; G. Bellini; H. Hessan; K. E. Kim; C. Swartz; M. Fernandes 1. Plasma volume, packed cell volume (PCV), blood volume, extracellular fluid volume (ECFV) and Evans blue disappearance rate were measured in conscious spontaneously hypertensive rats and in weight-matched Wistar normotensive...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (2): 249–251.
Published: 01 August 1981
...Kenji Mizuno; Shunichi Hata; Soitsu Fukuchi 1. The effect of sodium intake on angiotensin-converting enzyme activity in subcellular fractions of aorta (homogenate, mitochondria, microsomes and supernatant) was studied in normotensive and spontaneously hypertensive rats. 2. Angiotensin-converting...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (3): 267–272.
Published: 01 March 1981
...I. Tikkanen; A. Miettinen; F. Fyhrquist; T. Törnroth 1. To explore the effect of nephritis on development of genetic hypertension we immunized 10-week-old spontaneously hypertensive rats with purified rat kidney brush-border antigen. This induces Heymann nephritis (autologous immune complex...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (2): 229–232.
Published: 01 February 1981
...G. Berglund; L. Sigström; S. Lundin; B. E. Karlberg; H. Herlitz 1. Intra-erythrocyte sodium, potassium, ATP and (Na + ,K + -activated)-ATPase concentrations and urinary aldosterone excretion were compared in 3-month-old spontaneously hypertensive rats ( n = 11) and normotensive Wistar-Kyoto control...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 27s–29s.
Published: 01 December 1979
... arteries but only in the smallest cerebral arteries. Clinical Science (1979) 51,279-29s The ratio between thickness of media and internal radius in cerebral, mesenteric and renal arterial vessels in spontaneously hypertensive rats C. N O R D B O R G AND B. B. J O H A N S S O N Neuropathologtcal Laboratory...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (2): 163–167.
Published: 01 February 1979
... spontaneously hypertensive rat 16 5 1978 16 9 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 Clinical Science (1979) 56,163-167 The role of the baroreceptor reflex in the cardiovascular effects of propranolol in the conscious spontaneously hypertensive rat H...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (3): 261–270.
Published: 01 September 1978
...J. D. Barrett; P. Eggena; M. P. Sambhi 1. A renin-like enzyme in aortic tissue of the spontaneously hypertensive rat was found to be a freely dissociable enzyme (saline homogenization) with an affinity for the renin inhibitor pepstatin. At neutral pH values, the enzyme was active in homologous...