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Keyword: spontaneously hypertensive rats
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Articles
Clin Sci (Lond) (2001) 100 (6): 591–599.
Published: 25 April 2001
... was to explore the effects of long-term treatment (8 months) with a combination of an angiotensin type 1 (AT1) receptor antagonist, irbesartan (15 mg/kg per day), and an angiotensin-converting enzyme (ACE) inhibitor, captopril (100 mg/kg per day), in diabetic spontaneously hypertensive rats. Captopril...
Articles
Clin Sci (Lond) (1998) 95 (5): 583–587.
Published: 01 November 1998
... cellular magnesium or sodium content and exchange in vascular smooth muscle cells. 2. Therefore in aortic smooth muscle cells from 10 spontaneously hypertensive rats (SHR) of the Münster strain and 10 normotensive Wistar–Kyoto rats (WKY) aged 3 and 8–10 months, the intracellular magnesium and sodium...
Articles
Clin Sci (Lond) (1996) 91 (5): 539–550.
Published: 01 November 1996
... hypertension with cerebral, especially vertebrobasilar, atheroma. 5. Many of the pathophysiological changes in essential hypertension have parallels in the spontaneous hypertensive rat and its stroke-prone variant. Such rats have an impaired cerebral blood supply. Infarctions are easily produced by arterial...
Articles
Clin Sci (Lond) (1996) 91 (2): 147–154.
Published: 01 August 1996
...Xiao C. Li; Robert E. Widdop 16 4 1996 16 4 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 angiotensin II antagonists AT receptors CV-11974 EXP 3174 renal vasodilatation spontaneously hypertensive rats Clinical Science (1996) 91, 147-154...
Articles
Clin Sci (Lond) (1993) 85 (4): 425–429.
Published: 01 October 1993
...Zhiming Zhu; Martin Tepel; Marcus Neusser; Norbert Mehring; Walter Zidek 1. The effect of insulin on cytosolic free Ca 2+ concentration was measured using fura-2 in vascular smooth muscle cells of normotensive and spontaneously hypertensive rats. 2. In both strains, insulin increased cytosolic free...
Articles
Clin Sci (Lond) (1993) 84 (2): 129–132.
Published: 01 February 1993
...Irena Pohlová; Josef Zicha; Vladimir Křen; Jaroslav Kuneš; Michal Pravenec 1. A structural alteration within the first intron of the renin gene in spontaneously hypertensive rats was demonstrated to co-segregate with blood pressure in some sets of F 2 hybrids or recombinant inbred strains. There is...
Articles
Clin Sci (Lond) (1992) 82 (5): 513–519.
Published: 01 May 1992
... in spontaneously hypertensive rats but not in normotensive Wistar-Kyoto rats; the antagonist also blocked the pressor response to ventricularly infused bradykinin in both strains. 2. Bradykinin content was increased in the hypothalamus and septum and decreased in the dorsal medulla of spontaneously...
Articles
Clin Sci (Lond) (1991) 81 (2): 271–279.
Published: 01 August 1991
...P. G. McNally; F. Baker; N. Mistry; J. Walls; J. Feehally 1. Nifedipine ameliorates cyclosporin A-induced renal impairment in surgically intact (two-kidney) rats. This study investigates the effect of nifedipine on cyclosporin A nephrotoxicity in spontaneously hypertensive rats after either...
Articles
Clin Sci (Lond) (1990) 79 (5): 437–442.
Published: 01 November 1990
... spontaneously hypertensive rats compared with Wistar—Kyoto rats. 6. The atropine-sensitive metabolic effects of pilocarpine and electrical field stimulation on the pineal gland were increased in spontaneously hypertensive rats compared with Wistar-Kyoto rats. 12 3 1990 16 5 1990 © 1990 The...
Articles
Clin Sci (Lond) (1985) 69 (6): 721–726.
Published: 01 December 1985
... diuresis/natriuresis spontaneously hypertensive rats Clinical Science (1985) 69,721-726 721 Effect of natural and synthetic atrial natriuretic factor on arterial blood pressure, natriuresis and cyclic GMP excretion in spontaneously hypertensive rats STEPHEN C. PANG, MINH-CHAU HOANG, JOHANNE TREMBLAY...
Articles
Clin Sci (Lond) (1985) 69 (5): 511–515.
Published: 01 November 1985
...P. J. O. Manhem; S. A. Clark; W. B. Brown; G. D. Murray; J. I. S. Robertson 1. Chlorothiazide (100 mg/kg body weight) was given by gavage daily to spontaneously hypertensive rats for 4 weeks. Another group of spontaneously hypertensive rats was given only tap water and served as control. 2...
Articles
Clin Sci (Lond) (1985) 68 (2): 179–184.
Published: 01 February 1985
...Giacomo Bruschi; Maria E. Bruschi; Maurizio Caroppo; Guido Orlandini; Marco Spaggiari; Angelo Cavatorta 1. The cytoplasmic free calcium concentration ([Ca 2+ ] i ) was assessed with the fluorescent dye Quin 2 in platelets and lymphocytes of spontaneously hypertensive rats (SHR), normotensive Wistar...
Articles
Clin Sci (Lond) (1985) 68 (1): 35–43.
Published: 01 January 1985
...W. Gaida; R. E. Lang; K. Kraft; Th. Unger; D. Ganten 1. Changes in brain neuropeptide content in spontaneously hypertensive rats may be primarily related to the development of hypertension or may be secondary consequences of it. 2. We have measured brain concentrations of β-endorphin, Leu...
Articles
Clin Sci (Lond) (1984) 66 (4): 421–426.
Published: 01 April 1984
... endogenous corticosteroids. 1 9 1983 18 10 1983 © 1984 The Biochemical Society and the Medical Research Society 1984 aldosterone dexamethasone Na,K-dependent adenosine triphosphatase spontaneously hypertensive rats Clinical Science (1984) 66,421-426 421 The role of...
Articles
Clin Sci (Lond) (1982) 63 (s8): 117s–119s.
Published: 01 October 1982
... rats still respond satisfactorily to the strong stimulus of severe dehydration. © 1982 The Biochemical Society and the Medical Research Society 1982 [arginine]vasopressin brain vasopressin spontaneously hypertensive rats CIinicalScience (1982) 63,117s-119s 117s Reduced synthesis of...
Articles
Clin Sci (Lond) (1982) 63 (s8): 309s–311s.
Published: 01 October 1982
... frequency related vasoconstriction as well as [ 3 H]noradrenaline release were observed over the stimulating range of 0.25-32 Hz in both the Wistar-Kyoto and spontaneously hypertensive rats. The spontaneously hypertensive rat kidneys exhibited both an increased vasoconstrictor response and a greater [ 3 H...
Articles
Clin Sci (Lond) (1982) 63 (s8): 187s–189s.
Published: 01 October 1982
...Mitsuhide Naruse; Tadashi Inagami 1. Three-week-old spontaneously hypertensive rats (SHR) showed markedly elevated specific renin activity in the adrenal and the mesenteric vessels compared with control Wistar-Kyoto (WKY)rats. 2. In 17-week-old SHR with established hypertension, adrenal renin...
Articles
Clin Sci (Lond) (1981) 61 (3): 295–298.
Published: 01 September 1981
...W. Rascher; E. Weidmann; F. Gross 1. Plasma concentration of arginine vasopressin, plasma osmolality and packed cell volume were measured in stroke-prone spontaneously hypertensive rats (SHRSP) and in normotensive Wistar-Kyoto (WKY) rats at different ages. 2. In young and in adolescent SHRSP, at 6...
Articles
Clin Sci (Lond) (1981) 61 (3): 313–316.
Published: 01 September 1981
...R. B. Jones; J. Patrick; P. J. Hilton 1. The intracellular sodium content and the sodium efflux rate constant have been determined in vitro in thymocytes derived from the Okamato-Aoki strain of spontaneously hypertensive rats. 2. A strong positive correlation between the systolic blood pressure and...
Articles
Clin Sci (Lond) (1981) 61 (s7): 199s–202s.
Published: 01 January 1981
... hypertensive rats Clinical Science (1981) 61,199s-202s 199s Plasma concentrations of catecholamines in two strains of spontaneously hypertensive rats at different ages P. F E R R A R I * , G . B . P I C O T T I T , E. M I N O T T I * , G . P. B O N D I O L O T T I ? , A . M. C A R A V A G G I * A N D G . B...
Articles
Clin Sci (Lond) (1981) 61 (s7): 109s–111s.
Published: 01 January 1981
...S. Lundin; P. Friberg; Margareta Hallbäck-Nordlander 1. The influence of different arterial pressures on the relationship between diastolic filling pressure and stroke volume was studied during pharmacological cardiac nerve blockade in adult, anaesthetized spontaneously hypertensive rats in...
Articles
Clin Sci (Lond) (1981) 61 (s7): 315s–318s.
Published: 01 January 1981
...G. J. Dusting; R. Di Nicolantonio; T. Drysdale; A. E. Doyle 1. Vasodepressor responses to prostacyclin and nitroprusside were compared in anaesthetized, spontaneously hypertensive rats of the Okamoto strain and Wistar—Kyoto controls, and also in one-kidney, one-clip hypertensive rats and...
Articles
Clin Sci (Lond) (1981) 61 (s7): 121s–123s.
Published: 01 January 1981
... cells isoprenaline leucine noradrenaline ornithine decarboxylase propranolol spontaneously hypertensive rats thymidine Clinical Science (1981) 61, 121s-123s 121s Mechanisms of structural vascular changes in genetic hypertension: analyses on cultured vascular smooth muscle cells from...
Articles
Clin Sci (Lond) (1980) 59 (s6): 385s–387s.
Published: 01 January 1980
...P. J. Fletcher; Janice M. Pfeffer; M. A. Pfeffer; E. Braunwald 1. Haemodynamic changes during graded methoxamine infusion have been measured in 16 spontaneously hypertensive rats with healed myocardial infarction produced by left coronary artery ligation and in 15 hypertensive rats without...
Articles
Clin Sci (Lond) (1980) 59 (s6): 291s–294s.
Published: 01 January 1980
...: 0.03-0.1 mg min −1 kg −1 intra-arterially) produced sustained decreases in blood pressure measured from the cannulated tail artery in conscious spontaneously hypertensive rats. 3. This antihypertensive action of DPDA was antagonized by sulpiride but not by atropine, promethazine, propranolol or...
Articles
Clin Sci (Lond) (1980) 59 (s6): 251s–253s.
Published: 01 January 1980
...D. H. Suarez; Barbara L. Pegram; E. D. Frohlich 1. Systemic and regional haemodynamics were determined in conscious Wistar-Kyoto and spontaneously hypertensive rats with the radioactive microsphere technique after sham lesion or bilateral electrolytic lesion of the nuclei of the anterior...
Articles
Clin Sci (Lond) (1980) 59 (s6): 389s–391s.
Published: 01 January 1980
...S. Lundin; B. Folkow; P. Friberg; B. Rippe 1. Central blood volume and total blood volume were determined in spontaneously hypertensive rats and Wistar-Kyoto rats at two ages (6 and 12 weeks), representing ‘borderline’ hypertension and early ‘established’ hypertension. 2. A technique was used where...
Articles
Clin Sci (Lond) (1980) 59 (s6): 449s–452s.
Published: 01 January 1980
...Shozo Ishise; Barbara L. Pegram; E. D. Frohlich 1. Wistar-Kyoto and spontaneously hypertensive rats were given either methyldopa (400 mg day −1 kg −1 ) or clonidine (0.1 or 0.3 mg day −1 kg −1 ) for 3 weeks commencing at 20 weeks of age. 2. Both drugs significantly decreased mean arterial pressure...
Articles
Clin Sci (Lond) (1980) 59 (s6): 171s–173s.
Published: 01 January 1980
...R. Dietz; A. Schoumig; W. Rascher; R. Strasser; W. Kubler 1. Salt loading accelerates and increases the rise in blood pressure (spSH) in stroke-prone spontaneously hypertensive rats, but not in Wistar-Kyoto (WK) rats. 2. In both strains a slight increase in plasma volume was obtained during salt...
Articles
Clin Sci (Lond) (1980) 59 (s6): 79s–82s.
Published: 01 January 1980
...J. S. Hutchinson; A. E. Doyle 1. Neurosecretion of peptides from superfused neurohypophyses in vitro was inhibited by dopamine. 2. This inhibition was dose-dependent. 3. Intravenous injection of the dopamine agonist, bromocriptine, lowered blood pressure in spontaneously hypertensive rats within 15...
Articles
Clin Sci (Lond) (1980) 59 (s6): 235s–237s.
Published: 01 January 1980
... enkephalin peptides spontaneously hypertensive rats vasopressin ClinicalScience (1980) 5 9 , 2 3 5 ~ 2 3 1 s 235s Increased pressor responsiveness to enkephalin in spontaneously hypertensive rats: the role of vasopressin R . W. R O C K H O L D , J . T . C R O F T O N A N D L. S H A R E Department of...
Articles
Clin Sci (Lond) (1979) 56 (6): 585–589.
Published: 01 June 1979
... observed. 2. Administration of SQ 14225 with the drinking fluid overnight suppressed the pressor responses to intravenous angiotensin I, although the blood pressure increase after intravenous angiotensin II was not altered in normotensive and spontaneously hypertensive rats. No change of pressor effects...
Articles
Clin Sci (Lond) (1979) 57 (s5): 35s–37s.
Published: 01 January 1979
... stroke-proneness. © 1979 The Biochemical Society and the Medical Research Society 1979 blood vessels collagen connective tissue spontaneously hypertensive rats Clinical Science (1979) 5 1,359-37s Biochemical alterations of connective tissue metabolism in the arterial walls of stroke-prone...
Articles
Clin Sci (Lond) (1979) 57 (s5): 329s–331s.
Published: 01 January 1979
... spontaneously hypertensive rats Clinical Science (1979) 51,3299-331s Clinical and pathological relevance of erythrocyte cation fluxes measurement in hypertension R. P. GARAY, M. D E M E N D O N C A , J . L. E L G H O Z I , M. A. DEVYNCK, G. D A G H E R , M. G. PERNOLLET, M. L. G R I C H O I S , D. BEN-ISHAY...
Articles
Clin Sci Mol Med (1978) 55 (3): 317–320.
Published: 01 September 1978
...C. R. Hiley; M. S. Yates 1. Radioactive 15 μm and 50 μm diameter microspheres were used to determine cardiac output, its regional distribution and tissue blood flow in adult normotensive Wistar and Okamoto spontaneously hypertensive rats. 2. Cardiac output in the spontaneously hypertensive rats was...
Articles
Clin Sci Mol Med (1978) 55 (s4): 255s–257s.
Published: 01 January 1978
...A. Scriabine; C. T. Ludden; C. S. Sweet; C. C. Porter; E. H. Ulm; C. A. Stone; C. J. Watkins; R. J. Wurtman; B. L. Cronin 1. Metyrosine (l-α-methyl- p -tyrosine, Demser), an inhibitor of tyrosine hydroxylase, has moderate antihypertensive activity in spontaneously hypertensive rats (20–40 mmHg fall...
Articles
Clin Sci Mol Med (1976) 51 (s3): 385s–389s.
Published: 01 January 1976
...J. L. Elghozi; J. Altman; M. A. Devynck; J. F. Liard; J. P. Grunfeld; P. Meyer 1. Injections of antagonists of angiotensin II into the cerebral ventricles of normotensive and spontaneously hypertensive rats were performed in order to assess the role of the isorenin—angiotensin system in the brain...
Articles
Clin Sci Mol Med (1975) 49 (1): 69–71.
Published: 01 July 1975
... suggested that the lowered kallikrein may be related to the development of hypertension. 28 1 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 blood pressure bradykinin kallikrein sodium spontaneously hypertensive rats CIinical Science and Molecular Medicine...
Articles
Clin Sci Mol Med (1974) 48 (s2): 205s–214s.
Published: 01 January 1974
...B. Folkow Consideration of the results obtained in studies of spontaneously hypertensive rats indicates that these animals can serve as useful models for perhaps the most common type of essential hypertension of man. Other variants of essential hypertension probably occur where the relative balance...
Articles
Clin Sci Mol Med (1974) 48 (s2): 181s–184s.
Published: 01 January 1974
...M. Fernandes; I. Sanford Smith; A. Weder; K. E. Kim; Anne B. Gould; Patricia Busby; C. Swartz; G. Onesti 1. Prazosin decreases blood pressure in normotensive, renal hypertensive and spontaneous hypertensive rats. The effect is greatest in the last-named. 2. In spontaneously hypertensive rats the...
Articles
Clin Sci Mol Med (1974) 48 (s2): 265s–268s.
Published: 01 January 1974
... diabetes insipidus are virtually non-responsive to intraventricular angiotensin. 5. Angiotensin II is elevated in the cerebrospinal fluid of spontaneously hypertensive rats. 6. An intraventricular perfusion of the angiotensin II receptor-blocking agent P 113 decreases blood pressure in spontaneously...
Articles
Clin Sci Mol Med (1973) 45 (s1): 325s–329s.
Published: 01 August 1973
... hypertensive rats than in normal Wistar rats in each dietary group. © 1994 The Biochemical Society and the Medical Research Society 1994 prostaglandins sodium loading sodium restriction hypertension spontaneously hypertensive rats kidney Clinical Science and Molecular Medicine (1973) 45,325...