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Keywords: spontaneously hypertensive rats
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Clin Sci (Lond) (1996) 91 (5): 539–550.
Published: 01 November 1996
... hypertension with cerebral, especially vertebrobasilar, atheroma. 5. Many of the pathophysiological changes in essential hypertension have parallels in the spontaneous hypertensive rat and its stroke-prone variant. Such rats have an impaired cerebral blood supply. Infarctions are easily produced by arterial...
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Clin Sci (Lond) (1993) 84 (2): 129–132.
Published: 01 February 1993
...Irena Pohlová; Josef Zicha; Vladimir Křen; Jaroslav Kuneš; Michal Pravenec 1. A structural alteration within the first intron of the renin gene in spontaneously hypertensive rats was demonstrated to co-segregate with blood pressure in some sets of F 2 hybrids or recombinant inbred strains...
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Clin Sci (Lond) (1992) 82 (5): 513–519.
Published: 01 May 1992
... in spontaneously hypertensive rats but not in normotensive Wistar-Kyoto rats; the antagonist also blocked the pressor response to ventricularly infused bradykinin in both strains. 2. Bradykinin content was increased in the hypothalamus and septum and decreased in the dorsal medulla of spontaneously hypertensive...
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Clin Sci (Lond) (1981) 61 (s7): 315s–318s.
Published: 01 December 1981
...G. J. Dusting; R. Di Nicolantonio; T. Drysdale; A. E. Doyle 1. Vasodepressor responses to prostacyclin and nitroprusside were compared in anaesthetized, spontaneously hypertensive rats of the Okamoto strain and Wistar—Kyoto controls, and also in one-kidney, one-clip hypertensive rats...
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Clin Sci (Lond) (1980) 59 (s6): 385s–387s.
Published: 01 December 1980
...P. J. Fletcher; Janice M. Pfeffer; M. A. Pfeffer; E. Braunwald 1. Haemodynamic changes during graded methoxamine infusion have been measured in 16 spontaneously hypertensive rats with healed myocardial infarction produced by left coronary artery ligation and in 15 hypertensive rats without...
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Clin Sci (Lond) (1980) 59 (s6): 291s–294s.
Published: 01 December 1980
...: 0.03-0.1 mg min −1 kg −1 intra-arterially) produced sustained decreases in blood pressure measured from the cannulated tail artery in conscious spontaneously hypertensive rats. 3. This antihypertensive action of DPDA was antagonized by sulpiride but not by atropine, promethazine, propranolol...
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Clin Sci (Lond) (1980) 59 (s6): 251s–253s.
Published: 01 December 1980
...D. H. Suarez; Barbara L. Pegram; E. D. Frohlich 1. Systemic and regional haemodynamics were determined in conscious Wistar-Kyoto and spontaneously hypertensive rats with the radioactive microsphere technique after sham lesion or bilateral electrolytic lesion of the nuclei of the anterior...
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Clin Sci (Lond) (1980) 59 (s6): 449s–452s.
Published: 01 December 1980
...Shozo Ishise; Barbara L. Pegram; E. D. Frohlich 1. Wistar-Kyoto and spontaneously hypertensive rats were given either methyldopa (400 mg day −1 kg −1 ) or clonidine (0.1 or 0.3 mg day −1 kg −1 ) for 3 weeks commencing at 20 weeks of age. 2. Both drugs significantly decreased mean arterial pressure...
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Clin Sci (Lond) (1979) 57 (s5): 329s–331s.
Published: 01 December 1979
...+ pump, spontaneously hypertensive rats. Introduction In a recent study of net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients, we reported a decreased net Na+ efflux in accelerated cases and an increase in net K+ influx in moderately hypertensive subjects. Therefore in all essential...
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Clin Sci Mol Med (1976) 51 (s3): 385s–389s.
Published: 01 December 1976
...J. L. Elghozi; J. Altman; M. A. Devynck; J. F. Liard; J. P. Grunfeld; P. Meyer 1. Injections of antagonists of angiotensin II into the cerebral ventricles of normotensive and spontaneously hypertensive rats were performed in order to assess the role of the isorenin—angiotensin system in the brain...
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Clin Sci Mol Med (1975) 48 (s2): 181s–184s.
Published: 01 January 1975
...M. Fernandes; I. Sanford Smith; A. Weder; K. E. Kim; Anne B. Gould; Patricia Busby; C. Swartz; G. Onesti 1. Prazosin decreases blood pressure in normotensive, renal hypertensive and spontaneous hypertensive rats. The effect is greatest in the last-named. 2. In spontaneously hypertensive rats...
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Clin Sci Mol Med (1975) 48 (s2): 265s–268s.
Published: 01 January 1975
... diabetes insipidus are virtually non-responsive to intraventricular angiotensin. 5. Angiotensin II is elevated in the cerebrospinal fluid of spontaneously hypertensive rats. 6. An intraventricular perfusion of the angiotensin II receptor-blocking agent P 113 decreases blood pressure in spontaneously...
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