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1-15 of 15
Keywords: stable isotope
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Articles
Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline
Available to PurchaseJonathan Grip, Towe Jakobsson, Christina Hebert, Maria Klaude, Gustaf Sandström, Jan Wernerman, Olav Rooyackers
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (4): 375–384.
Published: 27 May 2015
... by Portland Press Limited 2015 We examined the usefulness of a three-compartment model for description of lactate kinetics using stable isotopically labelled lactate in humans. The main results showed that adrenaline increased lactate release from, and mitochondrial ex vivo respiration in, human...
Articles
Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
... in this short-term (8 h) dose–response study. L -Arginine-HCl was continuously infused [intravenously (IV)] in three stepwise-increasing doses (33, 66 and 99 μmol·kg −1 ·h −1 ). Whole-body arginine-NO and protein metabolism were measured using stable isotope techniques, and baseline values were compared...
Includes: Supplementary data
Articles
Altered protein metabolism following coronary artery bypass graft (CABG) surgery
Available to PurchaseGiuseppe Caso, James A. Vosswinkel, Peter J. Garlick, Mohamed K. Barry, Thomas V. Bilfinger, Margaret A. Mcnurlan
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (4): 339–346.
Published: 15 January 2008
... cardiopulmonary bypass coronary artery bypass graft (CABG) fibrinogen muscle protein synthesis stable isotope Surgical trauma is accompanied by accelerated protein catabolism with mobilization of amino acids [ 1 ]. Following surgery, the rate of protein synthesis is reduced in skeletal muscle [ 2 – 4...
Articles
Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice
Available to PurchaseYvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery SAP concentrations in plasma were measured using a sandwich ELISA...
Articles
Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response
Available to PurchaseHans Barle, Folke Hammarqvist, Bo Westman, Maria Klaude, Olav Rooyackers, Peter J. Garlick, Jan Wernerman
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (1): 93–99.
Published: 12 December 2005
... reaction undergoing laparoscopic cholecystectomy. Correspondence: Dr Hans Barle (email [email protected] ). 19 7 2005 23 8 2005 6 9 2005 6 9 2005 The Biochemical Society 2006 cholecystitis inflammation liver protein MS stable isotope synthesis rate...
Articles
13 C- and 2 H-labelled glucose compared for minimal model estimates of glucose metabolism in man
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (6): 513–521.
Published: 23 November 2005
... test (IVGTT) minimal model stable isotope The primary measure of the equivalence of the behaviour of the two tracers was the direct comparison of the plasma tracer concentrations [ 11 ]. For all 40 IVGTTs performed, the correlation between the mole fractions of the two tracers was extremely...
Articles
Impact of surgical trauma on human skeletal muscle protein synthesis
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (6): 601–607.
Published: 24 November 2004
... and the assessment of protein synthesis was completed according to an identical protocol that applied for the pre-operative measurement. protein synthesis skeletal muscle stable isotope surgical trauma Muscle protein catabolism is a considerable clinical problem following surgical trauma. This muscle...
Articles
Holmium as a faecal marker for copper absorption studies in adults
Available to PurchaseLinda J. HARVEY, Gosia MAJSAK-NEWMAN, Jack R. DAINTY, S. Gabrielle WHARF, Martin D. REID, John H. BEATTIE, Susan J. FAIRWEATHER-TAIT
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (2): 233–240.
Published: 14 January 2002
... stable isotope label. Ten volunteers (nine female, one male) aged 24-55 years were recruited from the Norwich area to take part in a free-living study. The study was conducted in the Human Nutrition Unit at the Institute of Food Research, Norwich, U.K., and involved feeding breakfast test meals...
Articles
Preliminary experience with a new stable isotope breath test for chylomicron remnant metabolism: a study in central obesity
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (6): 683–690.
Published: 20 November 2001
...G.F. WATTS; D.C.F. CHAN; P.H.R. BARRETT; I.J. MARTINS; T.G. REDGRAVE We aimed to investigate the metabolism of chylomicron remnants in the postabsorptive state employing a new stable isotope breath test in centrally obese men without overt hyperlipidaemia. Groups of 12 centrally obese and 12 non...
Articles
Determination of Protein Synthesis in Lymphocytes in Vivo after Surgery
Available to PurchasePia Essén, Margaret A. McNurlan, Anders Thorell, Inga Tjäder, Giuseppe Caso, Susan E. Anderson, Jan Wernerman, Peter J. Garlick
Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (1): 99–106.
Published: 01 July 1996
..., it is difficult to interpret these in vitro findings. Therefore, an in vivo technique has been established for determination of the fractional protein synthesis rate, as an index of metabolic activity in human peripheral blood lymphocytes, by using a stable isotope technique. 2. The rate of protein synthesis...
Articles
Effects of Fasting on Fatty Acid Kinetics and on the Cardiovascular, Thermogenic and Metabolic Responses to the Glucose Clamp
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (6): 697–706.
Published: 01 December 1994
... by fasting. 26 1 1994 11 7 1994 22 8 1994 © 1994 The Biochemical Society and the Medical Research Society 1994 euglycaemic clamp fasting glucose-induced thermogenesis lipolysis [I- 13 C]palmitate stable isotope Clinical Science (1994) 87, 697-706 (Printed in Great Britain...
Articles
Studies of human zinc kinetics using the stable isotope 70 Zn
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (1): 113–117.
Published: 01 January 1993
... : control subjects, 0.018 ± 0.002 min −1 , alcoholic patients, 0.031 ± 0.006 min −1 ). 5. These data therefore demonstrate that kinetic studies using stable isotopes of Zn can provide novel information on exchangeable Zn pools in man, but provide no support for the possibility of an underlying Zn depletion...
Articles
Absorption of non-haem iron in normal women measured by the incorporation of two stable isotopes into erythrocytes
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (2): 213–219.
Published: 01 August 1992
... and the Medical Research Society 1992 erythrocyte inductively coupled plasma iron absorption mass spectrometry plasma volume stable isotope Clinical Science (1992) 83, 213-219 (Printed in Great Britain) 213 Absorption of nophaem iron in normal women measured by the incorporation of two stable...
Articles
Albumin metabolism in fasted subjects during late pregnancy
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (2): 161–168.
Published: 01 August 1991
... intravascular albumin mass pregnancy stable isotope whole-body protein turnover ClinicalScience (1991) 81,161-168 161 Albumin metabolism in fasted subjects during late pregnancy 0. SAMSON OLUFEMI*, PAUL G. WHITTAKER, DAVE HALLIDAYT AND TOM LIND University Department of Obstetrics and Gynaecology, Princess...
Articles
Urea, Glucose and Alanine Kinetics in Man: Effects of Glucose Infusion
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (5): 553–556.
Published: 01 May 1982
... with stable isotopes, [ 15 N 2 ]urea, [6- 2 H]glucose and [3- 13 C]alanine, was used. 3. The rate of appearance of glucose and urea in the plasma was rapidly reduced by the 17.7 μUmol min −1 kg −1 glucose infusion. 4. In contrast, during the glucose infusion there was an increased rate of appearance...