... by Portland Press Limited 2015 We examined the usefulness of a three-compartment model for description of lactate kinetics using stable isotopically labelled lactate in humans. The main results showed that adrenaline increased lactate release from, and mitochondrial ex vivo respiration in, human...

... in this short-term (8 h) dose–response study. L -Arginine-HCl was continuously infused [intravenously (IV)] in three stepwise-increasing doses (33, 66 and 99 μmol·kg −1 ·h −1 ). Whole-body arginine-NO and protein metabolism were measured using stable isotope techniques, and baseline values were compared...

... graft (CABG) fibrinogen muscle protein synthesis stable isotope Surgical trauma is accompanied by accelerated protein catabolism with mobilization of amino acids [ 1 ]. Following surgery, the rate of protein synthesis is reduced in skeletal muscle [ 2 – 4 ], so amino acids are available...

... of stable isotopes of L -arginine { L -[guanidino- 15 N 2 - 2 H 2 ]arginine ([ 15 N 2 2 H 2 ]Arg); 99% atom percentage excess} and L -citrulline { L -[ureido- 15 N]citrulline ([ 15 N]Cit); 99% atom percentage excess} (Mass Trace) was given via the jugular vein (prime, 146 nmol [ 15 N 2 2 H 2 ]Arg/10 g...

... stable isotope synthesis rate Catabolic states are characterized by specific changes in protein metabolism. As the liver plays an important role in protein metabolism, this organ is vital for the response to a catabolic insult. Based primarily on results from studies in animals, the concept...

... diabetes glucose effectiveness insulin sensitivity intravenous glucose tolerance test (IVGTT) minimal model stable isotope Interpretation of the IVGTT (intravenous glucose tolerance test) by the minimal model of glucose kinetics is widely used in the determination of S I (insulin...

... minor. All patients were awake during the second determination of FSR. Correspondence: Dr Inga Tjäder (email [email protected] ). 2 7 2004 19 8 2004 24 8 2004 24 8 2004 The Biochemical Society 2004 protein synthesis skeletal muscle stable isotope...

... stable isotope label. Ten volunteers (nine female, one male) aged 24-55 years were recruited from the Norwich area to take part in a free-living study. The study was conducted in the Human Nutrition Unit at the Institute of Food Research, Norwich, U.K., and involved feeding breakfast test meals...

...G.F. WATTS; D.C.F. CHAN; P.H.R. BARRETT; I.J. MARTINS; T.G. REDGRAVE We aimed to investigate the metabolism of chylomicron remnants in the postabsorptive state employing a new stable isotope breath test in centrally obese men without overt hyperlipidaemia. Groups of 12 centrally obese and 12 non...

..., it is difficult to interpret these in vitro findings. Therefore, an in vivo technique has been established for determination of the fractional protein synthesis rate, as an index of metabolic activity in human peripheral blood lymphocytes, by using a stable isotope technique. 2. The rate of protein synthesis...

... by fasting. 26 1 1994 11 7 1994 22 8 1994 © 1994 The Biochemical Society and the Medical Research Society 1994 euglycaemic clamp fasting glucose-induced thermogenesis lipolysis [I- 13 C]palmitate stable isotope Clinical Science (1994) 87, 697-706 (Printed in Great Britain...

... : control subjects, 0.018 ± 0.002 min −1 , alcoholic patients, 0.031 ± 0.006 min −1 ). 5. These data therefore demonstrate that kinetic studies using stable isotopes of Zn can provide novel information on exchangeable Zn pools in man, but provide no support for the possibility of an underlying Zn depletion...

... and the Medical Research Society 1992 erythrocyte inductively coupled plasma iron absorption mass spectrometry plasma volume stable isotope Clinical Science (1992) 83, 213-219 (Printed in Great Britain) 213 Absorption of nophaem iron in normal women measured by the incorporation of two stable...

... intravascular albumin mass pregnancy stable isotope whole-body protein turnover ClinicalScience (1991) 81,161-168 161 Albumin metabolism in fasted subjects during late pregnancy 0. SAMSON OLUFEMI*, PAUL G. WHITTAKER, DAVE HALLIDAYT AND TOM LIND University Department of Obstetrics and Gynaecology, Princess...

... with stable isotopes, [ 15 N 2 ]urea, [6- 2 H]glucose and [3- 13 C]alanine, was used. 3. The rate of appearance of glucose and urea in the plasma was rapidly reduced by the 17.7 μUmol min −1 kg −1 glucose infusion. 4. In contrast, during the glucose infusion there was an increased rate of appearance...