..., who had been hospitalized for an ACS At 2 years, a RR reduction of 16% (95%CI, 5–26%; P =0.005) in the primary endpoint rate in patients receiving intensive statin treatment compared with standard statin therapy Bohula et al., 2015 [ 14 ] IMPROVE-IT Simvastatin, 40 mg/day versus ezetimibe, 10...

... for PCR amplification of contaminating genomic DNA. Atherosclerosis cardiovascular events microRNA peripheral blood mononuclear cell statins telomere Telomeres are localized at the ends of chromosomes and play an essential role in the aging of human cells [ 1 ]. Human telomeric DNA...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cholesterol cognitive impairment hypercholesterolaemia statins vascular dementia The three most common dementia subtypes are Alzheimer's disease (AD), vascular dementia (VaD) and mixed dementia...

...Jerome Morel; Iain Hargreaves; David Brealey; Viruna Neergheen; Janne T. Backman; Sandro Lindig; Marcus Bläss; Michael Bauer; Daniel F. McAuley; Mervyn Singer Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated...

... whereas others found no significant role for the LDLR in that process. This elusive pathway appears clearly distinct from that of the widely prescribed statins that also enhance LDLR function but do not lower circulating Lp (a) levels in humans. So how does PCSK9 inhibition with mAbs reduce Lp...

... is observed during dementia and hypercholesterolaemia. We investigated the hypothesis that statin intervention in mid-life mitigates the inflammatory effects of oxLDL on the microvasculature. Human microvascular endothelial cells (HMVECs) were maintained in transwells to mimic the microvasculature and exposed...

...Justin C. MASON The statins reduce cholesterol synthesis through inhibition of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase and are widely prescribed for hyperlipidaemia to reduce the risk of atherosclerotic complications. The beneficial effect of lipid lowering by statins in the treatment...