... a is both pro-angiogenic and neuroprotective, but pro-nociceptive and increases vascular permeability in animal models. Streptozotocin (STZ)-induced diabetic rats develop both hyperglycaemia and many of the resulting diabetic complications seen in patients, including peripheral neuropathy. In the present...

... tissue and muscle), in macrosomic offspring of streptozotocin-induced mildly hyperglycaemic rats. Food intake and nutritional efficiency were also evaluated. Mild hyperglycaemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation...

...Gil ARI; Yoram VARDI; John P. M. FINBERG The purpose of this investigation was to study the time course, response to insulin and characteristics of erectile dysfunction in streptozotocin (STZ)-diabetic Sprague–Dawley rats, and the function of the NO-generating system in these animals. Copulation...

...-arginine and/or N -ω-nitro-l-arginine, a known nitric oxide synthase inhibitor in streptozotocin-induced diabetic rats. 2. Normal rats and rats drinking hypertonic glucose (10%) were used as time-controlled groups. Six weeks after administration of streptozotocin the diabetic rats had significantly higher...

... rats were rendered diabetic by neonatal streptozotocin treatment, and then were mated with untreated male spontaneously hypertensive rats. Moderately severe hyperglycaemia was maintained during the gestation. 3. The birth weight was significantly lower in the female offspring of the diabetic dams than...

... streptozotocin-diabetic rats maintained under moderate glycaemic control (∼300 mg/dl) were treated with either placebo ( n = 10 rat/group) or octreotide for 14 weeks. Uninephrectomized non-diabetic rats given either placebo or octreotide served as controls. 2. Average body weight was diminished and kidney weight...

...Colin D. Payton; J. M. Boulton-Jones 1. Streptozotocin was used to induce diabetes in two inbred strains of rats, Lewis and DA, known to have different glomerular properties. 2. Dietary protein intake, weight and plasma glucose were monitored during the course of the experiment, and, at regular...

... Society and the Medical Research Society 1989 chloroquine diabetes glycated haemoglobin hypoglycaemia immunoreactive insulin streptozotocin Clinical Science (1989) 76, 137-141 Attenuation of streptozotocin-induced diabetes in rats by pretreatment with chloroquine KOJO A. ASAMOAH, BRIAN L...

...R. A. Hebden; S. M. Gardiner; T. Bennett; I. A. MacDonald 1. Intakes and urine outputs of fluid and electrolytes were measured daily in rats before, and for 3 weeks after, induction of diabetes by intraperitoneal injection of streptozotocin (STZ; 60 mg/kg); control animals received saline. 2. Water...

...P. N. Durrington; W. P. Stephens 1. No significant difference in serum high-density-lipoprotein (HDL) cholesterol was observed when control rats were compared with rats with streptozotocin-induced diabetes of 14 days duration. Blood glucose and serum cholesterol and triglyceride concentrations were...

...E. A. Elebute; R. A. Little 1. The effects of streptozotocin-diabetes on the local and general responses to a 4 h period of bilateral hind-limb ischaemia in the rat have been investigated. The rats were injured 48 h after the intravenous injection of the streptozotocin. 2. Less fluid was lost from...