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Keywords: stroke
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Articles
Clin Sci (Lond) (2023) 137 (23): 1787.
Published: 14 December 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . blood pressure digoxin migraine stroke The authors of the review...
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Clin Sci (Lond) (2023) 137 (20): 1595–1618.
Published: 25 October 2023
... on the potential implication of Na,K-ATPase-dependent intracellular signaling pathways in severe vascular disorders; ischemic stroke, familial migraine, and arterial hypertension. We propose similarity in the detrimental Na,K-ATPase-dependent signaling seen in these pathological conditions. The review includes...
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Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
...Sneha Raju; Jason E. Fish; Kathryn L. Howe Stroke is the leading cause of serious disability in the world and a large number of ischemic strokes are due to thromboembolism from unstable carotid artery atherosclerotic plaque. As it is difficult to predict plaque rupture and surgical treatment...
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Clin Sci (Lond) (2019) 133 (14): 1603–1607.
Published: 22 July 2019
...Sonu Bhaskar Diabetes is associated with poor recovery profiles following stroke. The pathophysiological mechanisms by which diabetes mediates neurological recovery after stroke are debatable. A recent paper published in the Clinical Science by Pintana et al. (Clinical Science (2019) 133 , 1367...
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Clin Sci (Lond) (2018) 132 (12): 1315–1328.
Published: 26 June 2018
...Emma L. Bailey; Martin W. McBride; John D. McClure; Wendy Beattie; Delyth Graham; Anna F. Dominiczak; Colin Smith; Joanna M. Wardlaw Background: The effect of salt on cerebral small vessel disease (SVD) is poorly understood. We assessed the effect of dietary salt on cerebral tissue of the stroke...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (10): 1055–1067.
Published: 25 May 2018
...Douglas M. Bennion; U. Muscha Steckelings; Colin Sumners Stroke is a devastating disease that afflicts millions of people each year worldwide. Ischemic stroke, which accounts for ~88% of cases, occurs when blood supply to the brain is decreased, often because of thromboembolism or atherosclerotic...
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Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
..., including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson’s disease. The present review is focused...
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Clin Sci (Lond) (2017) 131 (11): 1059–1068.
Published: 17 May 2017
.... It is frequently present along with other age-related pathologies such as Alzheimer's disease (AD). Multiple etiology dementia with both VCI and AD is the single most common cause of later life dementia. There are two main clinical syndromes of VCI: post-stroke VCI in which cognitive impairment is the immediate...
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Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
... that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as aging...
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Clin Sci (Lond) (2014) 127 (2): 77–89.
Published: 17 March 2014
... on miRNA expression following ischaemic stroke in an animal model. Adult (6 month) and middle-aged (11–12 months) female and male rats were subject to MCAo (middle cerebral artery occlusion) using ET-1 (endothelin-1). Circulating miRNAs were analysed in blood samples at 2 and 5 days post-stroke, and brain...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (5): 339–346.
Published: 25 October 2013
...Wen-Jun Tu; Sheng-Jie Zhao; Dong-Jiang Xu; Hui Chen Low vitamin D levels have been reported to contribute to the risk of cardiovascular events and mortality, especially stroke. In the present study we therefore evaluated the short-term prognostic value of serum 25(OH)D (25-hydroxyvitamin D...
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Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
...Robert W. Regenhardt; Douglas M. Bennion; Colin Sumners The goal of the present review is to examine the evidence for beneficial actions of manipulation of the RAS (renin–angiotensin system) in stroke, with particular focus on Ang-(1–7) [angiotensin-(1–7)] and its receptor Mas. The RAS appears...
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Clin Sci (Lond) (2012) 123 (3): 173–192.
Published: 12 April 2012
... and stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases. antioxidant ataxia diabetes free radical mitochondrion sepsis stroke ROS (reactive oxygen species), such as O 2 − (superoxide anion) and H 2 O 2 , are traditionally thought...
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Clin Sci (Lond) (2010) 118 (6): 375–389.
Published: 15 December 2009
...Hilary V.O. Carswell; I. Mhairi Macrae; Tracy D. Farr Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models. However, a recent clinical trial indicated that HRT (hormone-replacement therapy...
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Clin Sci (Lond) (2010) 118 (3): 183–185.
Published: 26 October 2009
...Simona Sacco; Antonio Carolei After a long debate, due to conflicting data from clinical studies, homocysteine is now largely accepted as a risk factor for cardiovascular diseases including stroke. To date, the role of elevated homocysteine levels in stroke recurrences has not been evaluated...
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Clin Sci (Lond) (2009) 117 (11): 387–395.
Published: 14 September 2009
... to stroke susceptibility. To test our hypothesis, we investigated the association of variants in the promoter of ANGPT2 with stroke in a multi-centre case-control study. We found that the C allele of rs3739390 conferred a 1.42-fold risk of lacunar infarction {adjusted OR (odds ratio), 1.42 [95% CI...
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Clin Sci (Lond) (2008) 114 (1): 37–47.
Published: 30 November 2007
...Jessica M. Osmond; Christine' S. Rigsby; Anne M. Dorrance In recent years, it has become increasingly clear that the extra-renal effects of aldosterone play an important role in the pathogenesis of cardiovascular disease. Stroke is one of the leading causes of death in the Western world, and MR...
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Clin Sci (Lond) (2004) 107 (5): 477–484.
Published: 26 October 2004
...Rajesh ULLEGADDI; Hilary J. POWERS; Salah E. GARIBALLA Evidence shows that there is a rapid increase in the production of markers of oxidative damage immediately following acute stroke and that endogenous antioxidant defences are rapidly depleted, thus permitting further tissue damage. Several...
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Clin Sci (Lond) (2004) 107 (1): 27–28.
Published: 23 June 2004
...Justin C. T. PEPPERELL Sleep apnoea is associated with increased cardiovascular risk. Sleep apnoea is common after stroke and associated with increased blood pressure variability as described by Turkington and co-workers in this issue of Clinical Science . Both sleep apnoea and blood pressure...
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Clin Sci (Lond) (2004) 107 (1): 75–79.
Published: 23 June 2004
...Peter M. TURKINGTON; John BAMFORD; Peter WANKLYN; Mark W. ELLIOTT Approx. 60% of acute stroke patients have periods of significant UAO (upper airway obstruction) and this is associated with a worse outcome. UAO is associated with repeated fluctuation in BP (blood pressure) and increased BP...
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Clin Sci (Lond) (1996) 91 (4): 399–413.
Published: 01 October 1996
...-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor treatment, comprising 2.4% (2.0 to 2.7) with a history of myocardial infarction, 1.9% (1.6 to 2.2) with angina and 0.5% (0.3–0.7) with a history of stroke-all with total cholesterol >5.5 mmol/l. The prevalence of these diagnoses with total...
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Clin Sci (Lond) (1995) 89 (3): 247–253.
Published: 01 September 1995
... aortic compliance is abnormal in patients with stroke. 2. Pulse wave velocity measurements of thoracoabdominal aortic compliance were made in 20 stroke patients and 25 age- and sex-matched hospitalized, non-stroke control subjects putatively free of cardiovascular disease. Since compliance varies...
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Clin Sci (Lond) (1981) 61 (s7): 369s–371s.
Published: 01 December 1981
...Paul K. Whelton; Peter Goldblatt 1. Analysis of age-adjusted death rates from 21 countries over a 20-year period identified the presence of a strong positive association between recorded mortality from stroke, hypertension and stomach cancer. However, the slopes of regression lines for secular...
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Clin Sci Mol Med (1976) 51 (s3): 673s–675s.
Published: 01 December 1976
... mortality was far higher in men than in women. 4. Causes of death were stroke in 17%, heart failure in 24%, coronary occlusion in 16%, uraemia in 4% and other diseases in 39%. At the first examination thirteen cases of malignant hypertension were registered, none at later sessions. © 1976 The Biochemical...
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Clin Sci Mol Med (1976) 51 (s3): 45s–48s.
Published: 01 December 1976
... malignant nephrosclerosis stroke Clinical Science and Molecular Medicine (1976) 51, 45-8s. Vasopressin and malignant deoxycorticosterone hypertension in rats J . M O H R I N G , B. M O H R I N G , M. P E T R I AND D. H A A C K Department of Pharmacology, University of Heidelberg, Heidelberg, Germany...
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Clin Sci Mol Med (1975) 48 (s2): 161s–163s.
Published: 01 January 1975
...K. Okamoto; F. Hazama; Y. Yamori; H. Haebara; A. Nagaoka 1. A colony of stroke-prone spontaneously hypertensive rats has been developed by selective breeding. 2. These animals developed severe hypertension early in life, the magnitude of the hypertension being closely related to the incidence...
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Clin Sci Mol Med (1975) 48 (s2): 127s–129s.
Published: 01 January 1975
... The Biochemical Society and the Medical Research Society 1975 renin sodium stroke Clinical Science and Molecular Medicine (1975) 48, 127s-129s. Plasma renin, urinary sodium excretion and vascular disease A. E. DOYLE, K. G. C H U A , S. D U F F Y A N D W. J. L O U I S Dcpartmeiit of Medicine, Austin...
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Clin Sci Mol Med (1973) 45 (s1): 205s–208s.
Published: 01 August 1973
... of arteriosclerosis does not seem to be influenced to the same degree. © 1994 The Biochemical Society and the Medical Research Society 1994 hypertension hypotensive drugs stroke myocardial infarction Clinical Science and Molecular Medicine (1973) 45, 205s-208s. C O M P L I C A T I O N S I N T R E A T E...
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Clin Sci Mol Med (1973) 45 (s1): 191s–193s.
Published: 01 August 1973
.... Since 1960 myocardial infarction, rather than cerebrovascular accident, has been the commonest cause of death. © 1994 The Biochemical Society and the Medical Research Society 1994 hypertension renal failure proteinuria stroke Clinical Science and Molecular Medicine (1973) 45, 191s-193s. T...