... recapitulating the stromal compartment comprising type I collagen, laminin, fibronectin, and stromal cells (fibroblasts and endothelial cells). ET-1-stimulated HG-SOC cells in the tumouroids showed an altered migration pattern and formed cellular aggregates, mimicking micrometastases that invaded the stroma...

.... Fibroblast-like cells of the stroma rather than malignant epithelial cells contribute most to the high level of collagen within the tumour ECM. The aberrant and destructive pattern of collagen bundles suggests a more readily degradable TME and thus may facilitate breast tumour invasion [ 36 ]. Network...