...William R. WADDELL 1. Sulindac, cis-5-fluoro-2-methyl-1-( p -methylsulphinylbenzylidene)indene-3-acetic acid, inhibits growth of colon polyps and cancers. This effect has been attributed to inhibition of prostaglandin synthesis but more recent observations indicate that, in vitro , cells that do...

...C. D. Mistry; C. J. Lote; R. Gokal; W. J. C. Currie; M. Vandenburg; N. P. Mallick 1. The renal effects of therapeutic doses of sulindac were studied in nine patients with stable renal insufficiency, mean creatinine clearance 37.0 ± 2.2 ml min −1 1.73 m −2 (range 24.7–54.6 ml min −1 1.73 m −2 ). 2...

...Charles P. Swainson; Peter Griffiths; Michael L. Watson 1. The effects of oral sulindac, 600 mg daily, on renal function and plasma hormones were studied in eight subjects with chronic renal failure. 2. Renal function and plasma hormones were measured before drug administration and then after...

.... Indomethacin is a NSAI drug with both renal and extrarenal cyclo-oxygenase inhibition properties. Sulindac is a relatively selective cyclooxygenase inhibitor said not to affect urinary prostaglandin excretion. 3. This study examines the relative effect on blood pressure of 4 weeks' treatment, with indomethacin...

...A. Salvetti; R. Pedrinelli; A. Magagna; P. Ugenti 1. The finding that sulindac, in contrast to indomethacin, does not inhibit renal prostaglandins synthesis in humans, prompted us to study the role that systemic and/or renal prostaglandins can play in the pharmacological responses to captopril...