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Keywords: superoxide dismutase
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Articles
Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... after 15 min of incubation. Linolenic acid caused a significantly lower inhibition of EDR than stearic acid. SOD (superoxide dismutase) restored the inhibitory effect caused by NEFAs, suggesting the involvement of ROS (reactive oxygen species) in removing nitric oxide. The nitric oxide concentration...
Articles
Clin Sci (Lond) (1999) 96 (4): 381–385.
Published: 01 April 1999
... compared with controls ( P < 0.005). Furthermore, an increase in plasma superoxide dismutase activity was also observed in relation to exercise ( P < 0.01). The elevation in plasma activities of antioxidant enzymes and the higher levels of free radical scavengers of low molecular mass may compensate...
Articles
Clin Sci (Lond) (1998) 94 (6): 623–632.
Published: 01 June 1998
... this study we aimed to identify whether oxidative stress occurs in the liver and pancreas in the initial stages of development of diabetes. 2. We therefore investigated the lipid peroxide level (thiobarbituric acid-reactive substances, TBARS) and activities of antioxidant enzymes [superoxide dismutase...
Articles
Clin Sci (Lond) (1998) 94 (4): 447–452.
Published: 01 April 1998
... years) and 47 healthy young (29.87 ± 0.53 years) volunteers, we studied the levels of antioxidant enzyme activity (superoxide dismutase, catalase and glutathione peroxidase), protein oxidative damage (as protein carbonyl content) and lysosomal proteolytic activity (cathepsins B, H and L), with and...
Articles
Clin Sci (Lond) (1996) 91 (4): 441–448.
Published: 01 October 1996
... activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) in aorta, heart and blood of control and streptozotocin-induced diabetic rats at various stages of development of diabetes (0 to 6 weeks). 2. There was no change in the TBARS levels of aorta, heart and blood in the...
Articles
Clin Sci (Lond) (1993) 85 (3): 353–359.
Published: 01 September 1993
...Rosa Maria Borzì; Brunella Grigolo; R. Meliconi; L. Fasano; C. Sturani; M. Fabbri; T. Porstmann; A. Facchini 1. Tissue damage in idiopathic pulmonary fibrosis is due in part to oxidant-antioxidant imbalance. 2. We evaluated the serum levels of the antioxidant enzyme Cu/Zn superoxide dismutase (EC...
Articles
Clin Sci (Lond) (1993) 84 (3): 287–295.
Published: 01 March 1993
...W. Sunman; A.D. Hughes; P.S. Sever 1. Small arteries were isolated from either rat mesentery or human subcutaneous fat, and mounted in a myograph for the measurement of isometric force. 2. Superoxide dismutase, either in the presence or absence of catalase, relaxed noradrenaline-induced tone. This...
Articles
Clin Sci (Lond) (1989) 77 (5): 463–466.
Published: 01 November 1989
...Ruth Shainkin-Kestenbaum; Andrew J. Adler; Geoffrey M. Berlyne; C. Caruso 1. The effect of Al 3+ on superoxide dismutase in vitro was studied, since in uraemia there is excessive superoxide production and frequently an elevated serum Al 3+ level. Thus, the protective role of superoxide dismutase is...
Articles
Clin Sci (Lond) (1987) 73 (3): 329–332.
Published: 01 September 1987
...M. Beaman; R. Birtwistle; A. J. Howie; J. Michael; D. Adu 1. The nephrotic syndrome was induced in inbred female Wistar rats by the intravenous injection of puromycin aminonucleoside (PA) (5 mg/100 g body weight). 2. One group ( n = 12) received superoxide dismutase (SOD) (15 mg/kg body weight), a...
Articles
Clin Sci (Lond) (1986) 71 (1): 57–60.
Published: 01 July 1986
... cerebrospinal fluid from patients with infantile and juvenile neuronal ceroid-lipofuscinosis were less protective against superoxide radical-induced hydroxyl radical formation compared with controls [3]. 2. The content of superoxide dismutase isoenzymes in cerebrospinal fluid and in plasma from patients with...
Articles
Clin Sci (Lond) (1986) 70 (4): 365–369.
Published: 01 April 1986
...Michael Öhman; Stefan L. Marklund 1. Disulfiram has long been used in the treatment of chronic alcoholism. It is in vivo partially reduced to diethyldithiocarbamate, which is an efficient inhibitor of Cu, Zn-containing superoxide dismutase both in vitro and in vivo. The recently described...
Articles
Clin Sci (Lond) (1985) 69 (6): 687–689.
Published: 01 December 1985
...D. B. Webb; R. Mackenzie; S. N. Zoob; A. J. Rees 1. The accelerated model of nephrotoxic serum nephritis (NTSN) was produced in 12 Sprague-Dawley rats. Six of these rats were administered superoxide dismutase (EC 1.15.1.1; SOD) subcutaneously (8 mg/kg) 8-hourly for 4 days. The first dose was given...
Articles
Clin Sci (Lond) (1983) 65 (6): 605–610.
Published: 01 December 1983
... pretreated with superoxide dismutase, another with catalase and the third group was not pretreated at all. 2. In non-pretreated ischaemic kidneys there was a significant trapping of labelled erythrocytes in the outer stripe of the medulla. This trapping was not seen in non-ischaemic control kidneys and was...
Articles
Clin Sci (Lond) (1982) 63 (3): 251–255.
Published: 01 September 1982
...Takeshi Saito; Keizo Ito; Masaaki Kurasaki; Shun Fujimoto; Hiroshi Kaji; Kazuo Saito 1. Activities, contents and true specific activities of superoxide dismutase (SOD) were determined in human erythrocytes of 105 normal healthy subjects. 2. The mean SOD activity assayed by the inhibition of...
Articles
Clin Sci (Lond) (1980) 58 (3): 211–219.
Published: 01 March 1980
... decrease in the activity of glutathione reductase in patients with secondary iron overload due to multiple transfusion therapy for thalassaemia major. 3. The activities of superoxide dismutase, catalase and glutathione peroxidase were similar in both patient groups. 4. Subcellular fractionation studies...
Articles
Clin Sci (Lond) (1980) 58 (2): 173–175.
Published: 01 February 1980
...Susumu Okahata; Yohnosuke Kobayashi; Tomofusa Usui 1. Erythrocyte superoxide dismutase activity was determined in 46 adults, 10 paediatric patients without anaemia and 11 paediatric patients with several types of anaemia. No difference was found in superoxide dismutase activity between adults and...
Articles
Clin Sci Mol Med (1978) 54 (5): 549–553.
Published: 01 May 1978
...T. J. Peters; Carol A. Seymour 1. Liver biopsies from two patients with the Dubin—Johnson—Sprinz syndrome were subjected to analytical subcellular fractionation by sucrose-density-gradient centrifugation and enzymic micro-assays. 2. A selective deficiency of mitochondrial superoxide dismutase has...
Articles
Clin Sci Mol Med (1977) 52 (4): 429–442.
Published: 01 April 1977
.... NAD(P)H/nitroblue tetrazolium reductase activity was partially inhibited by superoxide dismutase. 5. NADPH and NADH oxidase activities, measured by the production of oxidized nucleotide, were localized with the azurophil granules. 6. Superoxide dismutase, catalase, glutathione reductase and...