... the possible involvement of the sympathetic nervous system in the genesis of isolation-induced hypertension. 2. Male and female Wistar rats were treated neonatally with guanethidine, with a protocol designed to produce an extensive peripheral sympathectomy; control rats received saline. 3. The effects...

...A. R. Sinaiko; M. J. Cooper; B. L. Mirkin 1. Chemical sympathectomy was produced in spontaneously hypertensive rats by intraperitoneal injection of 6-hydroxydopamine hydrobromide (6-OHD) (100 μg/g body weight) on days 1, 4 and 7 of neonatal life and weekly thereafter until 6 weeks of age. The dose...

... nervous system, sympathectomy, recording of sympathetic discharge, hind-limb perfusion and study of noradrenaline. These factors are mainly involved in the initiation of hypertension, and they appear to diminish in importance after the establishment of hypertension, as indicated by the noradrenaline...