... inequalities oestrogen sex testosterone To approach medicine from a gender perspective is a relatively recent attempt to see as an opportunity the fact that the two sexes may have different experiences and manifestations of the same disease. The two sexes may, indeed, present with different symptoms...

...Andreia Z. Chignalia; Maria Aparecida Oliveira; Victor Debbas; Randal O. Dull; Francisco R.M. Laurindo; Rhian M. Touyz; Maria Helena C. Carvalho; Zuleica B. Fortes; Rita C. Tostes The mechanisms whereby testosterone increases cardiovascular risk are not clarified. However, oxidative stress...

... – 18 ]. arterial hypertension endothelin endothelin receptor end-organ damage 17β-oestradiol sex testosterone According to the Department of Reproductive Health and Research, World Health Organization (WHO Draft working definition, October 2002; http://www.who.int/reproductive...

... to promote increases in blood pressure and compromise renal function. In the present issue of Clinical Science , Malkin and co-workers show that testosterone replacement impairs vascular reactivity in men with androgen deficiency. These studies may shed light on the functional and therapeutic significance...

...Christopher J. Malkin; Richard D. Jones; T. Hugh Jones; Kevin S. Channer Testosterone is reported to have an acute vasodilating action in vitro , an effect that may impart a favourable haemodynamic response in patients with chronic heart failure. However, the effect of chronic testosterone exposure...

...Richard D. JONES; Kate M. ENGLISH; T. Hugh JONES; Kevin S. CHANNER Testosterone decreases myocardial ischaemia in men with coronary artery disease via a coronary vasodilatory action. However, long-term therapy may increase the risk of prostatic carcinoma via activation of the nuclear AR (androgen...

...K. J. ELLIOTT; N. T. CABLE; T. REILLY; M. J. DIVER To investigate the effect of changes in sex hormone concentration on muscle strength and the bioavailability of 17-β oestradiol (oestradiol) and testosterone, seven eumenorrheic females were tested during two phases of the menstrual cycle. Maximum...

... controls by time since menopause and by body mass index. Serum levels of androstenedione and total testosterone were measured by radioimmunoassays. Free testosterone was calculated from total testosterone, immunoassayed sex hormone-binding globulin and albumin. The mean±S.D. serum level of androstenedione...

... the effects of cigarette smoking on the levels of total and free testosterone have reported conflicting findings, but there has been no accurate assessment of the effects of cigarette smoking on the levels of bioavailable testosterone [not bound to sex hormone-binding globulin (SHBG)]. We attempted...

...Kate M. ENGLISH; Richard D. JONES; Hugh T. JONES; Alyn H. MORICE; Kevin S. CHANNER This study was performed to examine whether aging affects the vasodilatory effects of testosterone in the coronary arteries of male rats. Isolated coronary arteries from young mature (3–4 months) and elderly (22–26...

... expenditure (by indirect calorimetry) and circulating levels of catabolic (cortisol) and anabolic [testosterone, insulin-like growth factor-I (IGF-I)] hormones. Compared with the patients with a weight loss of < 10%, those with a weight loss of ⩾ 10% were characterized by higher levels of sTNF-R55 (trend...

... and the Medical Research Society 1970 adrenal cortex catecholamines prolactin psychological stress testosterone thyroid hormones Clinical Science (1988) 74,255-259 255 Endocrine effects of examination stress C. G. SEMPLE', C. E. GRAY2, W. B O U N D 2 , C. A. ESPIE3 AND G. H. BEASTALL2 'Department...

...M. Jawed Iqbal; Maureen Dalton; Robert S. Sawers 1. The percentage binding of testosterone (T) and oestradiol (E 2 ) to sex hormone binding globulin (SHBG) and human serum albumin (HSA) was determined over a range of SHBG concentrations of 16–250 nmol of dihydrotestosterone (DHT) bound/l...

... after ADH. 4. Castration, 24 h before study, abolished the ADH-induced fall in PRA, and testosterone implanted before castration did not restore the response. Cyproterone acetate reversed the ADH effect in males, so that PRA then rose after ADH. Hypophysectomized male rats, with depressed basal plasma...