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Keywords: therapeutics
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Clin Sci (Lond) (2022) 136 (16): 1229–1240.
Published: 31 August 2022
... metabolic regulation pulmonary fibrosis therapeutics transforming growth factors Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal chronic lung disease characterized by altered cellular composition and transitional states of resident epithelial and stromal cells and circulating...
Clin Sci (Lond) (2020) 134 (21): 2893–2895.
Published: 13 November 2020
... to decipher this complexity, alternative pragmatic strategies rely on attempts to produce therapeutic-grade artificial vesicles [ 15 ]. The vesicle ‘coat’ may prove to be critical: siRNA within a cell-derived vesicle is more effective at gene silencing than it is when delivered as naked nucleic acid...
Clin Sci (Lond) (2019) 133 (23): 2379–2400.
Published: 04 December 2019
... parturition. These results implicate BET proteins as novel therapeutic targets for reducing inflammation associated with spontaneous preterm labor. Brd2 siRNA (siBRD2), Brd3 (siBRD3), Brd4 (siBRD4) and negative control siRNA (siCONT) (Ambion; Thermo Fisher Scientific; Scoresby, Vic, Australia) were...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... cardiovascular and kidney diseases, kidney function continues to decline in people with established diabetic kidney disease (DKD). Despite the many advances and a greatly improved understanding of the pathobiology of diabetes and its complications, there remains a major unmet need for more effective therapeutics...
Clin Sci (Lond) (2019) 133 (8): 953–970.
Published: 29 April 2019
... data and public data [ 46–48 ]. Herein, Hedgehog signaling dysregulation in human cancer, Hedgehog signaling-targeted therapeutics and clinical trials of SMO inhibitors will be reviewed, and mechanisms of resistance to SMO inhibitors and strategies to enhance the clinical benefits of Hedgehog signaling...
Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
... of molecules related to and/or interacting with the TGFβ signalling pathway have been identified as potential therapeutic targets. However, due to its pleiotropic nature, complete inhibition of the TGFβ signalling pathway is likely to lead to deleterious side effects. Therefore, a better understanding...
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
... biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed...
Clin Sci (Lond) (2016) 130 (24): 2245–2256.
Published: 04 November 2016
... of these lncRNAs and designing strategies to detect and manipulate them, may present novel therapeutic and diagnostic opportunities. This review will explore the current literature on lncRNAs in skeletal and cardiac muscle and discuss their recent implication in development and disease. Lastly, we will also...
Clin Sci (Lond) (2016) 130 (18): 1665–1675.
Published: 08 August 2016
... compounds to modulate autophagy additionally to mitigate apoptosis. Overall, our in vitro and in vivo studies establish an association between TTR V30M aggregates and autophagy impairment and suggest the use of autophagy modulators as an additional and alternative therapeutic approach for the treatment...
Clin Sci (Lond) (2004) 107 (4): 331–341.
Published: 24 September 2004
... to resident bacteria in patients with IBD. Approaches to alter the intestinal microflora for therapeutic purposes and their potential mechanisms of action are also discussed. Correspondence: Professor Yashwant Mahida (email yash.mahida@nottingham.ac.uk ). 5 5 2004 14 6 2004 23 6 2004...
Clin Sci (Lond) (2002) 102 (3): 253–268.
Published: 11 February 2002
... pulmonary hypertension therapeutics transforming growth factor receptor. 253Clinical Science (2002) 102, 253 268 (Printed in Great Britain) + R E V I E W Recent insights into the pathogenesis and therapeutics of pulmonary hypertension Julian W. STRANGE, John WHARTON, Peter G. PHILLIPS and Martin R...