... metabolic regulation pulmonary fibrosis therapeutics transforming growth factors Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal chronic lung disease characterized by altered cellular composition and transitional states of resident epithelial and stromal cells and circulating...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . microRNA renal physiology therapeutics The renal tubular epithelial cell (rTEC) has been well-characterised with respect to its ability to release and take up extracellular RNA (exRNA) and EVs [ 1...

... parturition. These results implicate BET proteins as novel therapeutic targets for reducing inflammation associated with spontaneous preterm labor. Brd2 siRNA (siBRD2), Brd3 (siBRD3), Brd4 (siBRD4) and negative control siRNA (siCONT) (Ambion; Thermo Fisher Scientific; Scoresby, Vic, Australia) were...

... cardiovascular and kidney diseases, kidney function continues to decline in people with established diabetic kidney disease (DKD). Despite the many advances and a greatly improved understanding of the pathobiology of diabetes and its complications, there remains a major unmet need for more effective therapeutics...

...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 angiogenesis cancer hedgehog Immune-oncology tumor microenvironments therapeutics Sonic Hedgehog (SHH), Indian Hedgehog (IHH) and Desert Hedgehog (DHH) are lipid-modified secreted proteins that are involved...

... of molecules related to and/or interacting with the TGFβ signalling pathway have been identified as potential therapeutic targets. However, due to its pleiotropic nature, complete inhibition of the TGFβ signalling pathway is likely to lead to deleterious side effects. Therefore, a better understanding...

... biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed...

... of these lncRNAs and designing strategies to detect and manipulate them, may present novel therapeutic and diagnostic opportunities. This review will explore the current literature on lncRNAs in skeletal and cardiac muscle and discuss their recent implication in development and disease. Lastly, we will also...

... compounds to modulate autophagy additionally to mitigate apoptosis. Overall, our in vitro and in vivo studies establish an association between TTR V30M aggregates and autophagy impairment and suggest the use of autophagy modulators as an additional and alternative therapeutic approach for the treatment...

... to resident bacteria in patients with IBD. Approaches to alter the intestinal microflora for therapeutic purposes and their potential mechanisms of action are also discussed. Both types of IBD (inflammatory bowel disease), ulcerative colitis and Crohn's disease, can present at any age, but the peak...

... pulmonary hypertension therapeutics transforming growth factor receptor. 253Clinical Science (2002) 102, 253 268 (Printed in Great Britain) + R E V I E W Recent insights into the pathogenesis and therapeutics of pulmonary hypertension Julian W. STRANGE, John WHARTON, Peter G. PHILLIPS and Martin R...