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Keywords: therapeutics
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Clin Sci (Lond) (2020) 134 (21): 2893–2895.
Published: 13 November 2020
... the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . microRNA renal physiology therapeutics The renal tubular epithelial cell (rTEC) has been well-characterised with respect to its ability to release and take up extracellular RNA (exRNA...
Clin Sci (Lond) (2019) 133 (23): 2379–2400.
Published: 04 December 2019
... parturition. These results implicate BET proteins as novel therapeutic targets for reducing inflammation associated with spontaneous preterm labor. In the first cohort, 6 h after LPS injection, mice were killed by CO 2 asphyxiation followed by cervical dislocation. This time point was based on the LPS...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... cardiovascular and kidney diseases, kidney function continues to decline in people with established diabetic kidney disease (DKD). Despite the many advances and a greatly improved understanding of the pathobiology of diabetes and its complications, there remains a major unmet need for more effective therapeutics...
Clin Sci (Lond) (2019) 133 (8): 953–970.
Published: 29 April 2019
... microenvironments therapeutics Correspondence: Masaru Katoh ( mkatoh-kkr@umin.ac.jp ) 14 01 2019 24 03 2019 11 04 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Targeted therapies are promising options for cancer...
Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
... of molecules related to and/or interacting with the TGFβ signalling pathway have been identified as potential therapeutic targets. However, due to its pleiotropic nature, complete inhibition of the TGFβ signalling pathway is likely to lead to deleterious side effects. Therefore, a better...
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
... biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed...
Clin Sci (Lond) (2016) 130 (24): 2245–2256.
Published: 04 November 2016
... function of these lncRNAs and designing strategies to detect and manipulate them, may present novel therapeutic and diagnostic opportunities. This review will explore the current literature on lncRNAs in skeletal and cardiac muscle and discuss their recent implication in development and disease. Lastly, we...
Clin Sci (Lond) (2016) 130 (18): 1665–1675.
Published: 08 August 2016
... of both compounds to modulate autophagy additionally to mitigate apoptosis. Overall, our in vitro and in vivo studies establish an association between TTR V30M aggregates and autophagy impairment and suggest the use of autophagy modulators as an additional and alternative therapeutic approach for the...
Clin Sci (Lond) (2004) 107 (4): 331–341.
Published: 24 September 2004
... resident bacteria in patients with IBD. Approaches to alter the intestinal microflora for therapeutic purposes and their potential mechanisms of action are also discussed. Correspondence: Professor Yashwant Mahida (email yash.mahida@nottingham.ac.uk ). 5 5 2004 14 6 2004 23 6 2004...
Clin Sci (Lond) (2002) 102 (3): 253–268.
Published: 11 February 2002
... predisposition hypoxia pulmonary hypertension therapeutics transforming growth factor receptor. 253Clinical Science (2002) 102, 253 268 (Printed in Great Britain) + R E V I E W Recent insights into the pathogenesis and therapeutics of pulmonary hypertension Julian W. STRANGE, John WHARTON, Peter G...