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Keywords: thrombosis
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Clin Sci (Lond) (2020) 134 (16): 2189–2201.
Published: 26 August 2020
... biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence...
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Clin Sci (Lond) (2017) 131 (12): 1245–1260.
Published: 07 June 2017
... inadequately to standard antiplatelet therapy. Furthermore, they often experience recurrent events as well as side effects that include excess bleeding. This highlights the need for identification of novel regulators of diabetes-associated thrombosis to target for therapeutic intervention. It is well...
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Clin Sci (Lond) (2013) 124 (3): 123–137.
Published: 02 October 2012
... in thrombosis and wound healing with a particular focus on: (i) the influence of plasma FXIIIa on the formation of stable fibrin clots able to withstand mechanical and enzymatic breakdown through fibrin–fibrin cross-linking and cross-linking of fibrinolysis inhibitors, in particular α 2 -antiplasmin; (ii...
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Clin Sci (Lond) (2012) 122 (9): 397–407.
Published: 21 December 2011
... and treatment. atherosclerosis endothelial cell inflammation magnesium oxidative stress thrombosis A relevant issue is to consider how low Mg levels affect endothelial function. There is clear evidence that Mg deficiency, similarly to common cardiovascular risk factors, promotes oxidative...
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Clin Sci (Lond) (2009) 116 (11): 791–804.
Published: 01 May 2009
... neutrophils in ruptured plaques compared with eroded plaques, suggesting a role for this cell type in plaque destabilization [ 40 ]. The most important consequences of atherosclerosis, such as myocardial infarction and stroke, are caused by thrombosis. Thrombus formation is driven by plaque rupture...
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Clin Sci (Lond) (2008) 115 (4): 129–131.
Published: 15 July 2008
... atherosclerosis inflammation myocardial infarction ruptured plaque thrombosis Toll-like receptor (TLR) The search for biomarkers that reflect progression of atherosclerotic disease has resulted in a large number of systemically expressed candidates that are mostly thought to mirror a vascular...
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Clin Sci (Lond) (2008) 115 (4): 133–140.
Published: 15 July 2008
...Yuh Ishikawa; Mamoru Satoh; Tomonori Itoh; Yoshitaka Minami; Yuji Takahashi; Motoyuki Akamura Several reports suggest that a chronic inflammatory process plays a key role in coronary artery plaque instability and subsequent occlusive thrombosis. In a previous study, we found that TLR4 (Toll-like...
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Clin Sci (Lond) (2005) 108 (3): 255–263.
Published: 18 February 2005
... as binding and activation of FVII (factor VII) can result in thrombosis. Although PAR2 (protease-activated receptor-2) is expressed on vascular endothelium, its precise physiological significance and mechanism of activation have yet to be defined. In the present study, we investigated whether PAR2 can...
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Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... extent this contributes to the reduced vasodilatory capacity. The inflammatory response appears central for many of the manifestations of the CHF syndrome. aging circulatory physiology endothelial function heart failure inflammation thrombosis vasculature Correspondence: Dr Sven E...
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Clin Sci (Lond) (1995) 89 (3): 205–214.
Published: 01 September 1995
...Gregory Y. H. Lip; Gordon D. O. Lowe © 1995 The Biochemical Society and the Medical Research Society 1995 d-dimer fibrin thrombosis Clinical Science (1995) 89, 205-2214 (Printed in Great Britain) 205 Editorial Review Fibrin IHJimer: a useful clinical marker of thrombogenesis! Gregory...
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