...K. L. Evemy; P. Cummins; W. A. Littler 1. The effect of prolonged administration of β-adrenoreceptor-blocking agents was studied in growing rabbits. Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. 2. Animals given propranolol had a significantly lower heart rate...

... The Biochemical Society and the Medical Research Society 1978 amiloride epidemiology hydrochlorothiazide hypertension methyldopa timolol Clinical Science and Molecular Medicine (1978) 55,353s-354s Results of a national therapeutic trial conducted in 10 000 hypertensive patients by 2000 general...

...G. Muiesan; B. Magnani; E. Agabiti-Rosei; C. Alicandri; E. Ambrosioni; N. Miele 1. The effects of timolol alone and in combination with a fixed dose of hydrochlorothiazide and amiloride have been studied in a double-blind, controlled study in fifty-four patients with mild to moderate essential...

...P. Lund-Johansen; O. J. Ohm 1. Oxygen consumption and central haemodynamics were recorded at rest and during exercise in fifty-one men with essential hypertension (W.H.O. stage I) and repeated after 1 year on a single drug: alprenolol ( n = 10), atenolol (13) metoprolol (12) and timolol (16). 2...

...C. S. Sweet; M. Mandradjieff 1. Renal hypertensive dogs were treated with hydrochlorothiazide (8−2 μmol/kg or 33 μmol/kg daily for 7 days), or timolol (4.6 μmol/kg daily for 4 days), a potent β-adrenergic blocking agent, or combinations of these drugs). Changes in mean arterial blood pressure...