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Keywords: topoisomerases
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Articles
Clin Sci (Lond) (2021) 135 (10): 1311–1332.
Published: 28 May 2021
... result in cardiomyopathy and heart failure. Cardiomyocyte toxicity occurs via multiple molecular mechanisms, including topoisomerase II-mediated DNA double-strand breaks and reactive oxygen species (ROS) formation via effects on the mitochondrial electron transport chain, NADPH oxidases (NOXs...
Includes: Supplementary data