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Keywords: torsade de pointes
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Articles
Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG
Available to PurchaseKenshi HAYASHI, Masami SHIMIZU, Hidekazu INO, Masato YAMAGUCHI, Hidenobu TERAI, Naoto HOSHI, Haruhiro HIGASHIDA, Nariaki TERASHIMA, Yoshihide UNO, Honin KANAYA, Hiroshi MABUCHI
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (2): 175–182.
Published: 27 July 2004
... dysfunction, may manifest marked QT prolongation or torsade de pointes only upon an additional stressor. A 59-year-old woman had marked QT prolongation and repeated torsade de pointes 3 months after initiation of probucol, a cholesterol-lowering drug. We identified a single base substitution in the HERG gene...
