.... To profile transcriptomic signatures of the choroid plexus at single-cell resolution, we conducted single-nuclear RNA-seq of choroid plexus tissues (Figure 2A). ApoE-KO; BAC/APOL1-G1 mouse with hydrocephalus (n = 1) and ApoE-KO mouse without hydrocephalus (n = 1) in the littermates were used...

... day 5 to 15 in wild-type but not homozygote rat kidneys. The transcriptomic profile of renal tissue revealed several dysregulated pathways due to the lack of Xdh expression with the remodeling in inflammasome, purinergic signaling, and redox homeostasis. Further analysis suggested that lack of Xdh...

... the cellular mechanisms that underlie female resilience, we utilized blood–brain barrier (BBB) and hippocampal transcriptomic analyses in heterozygous mice before seizure onset (pre-TC) and in mice that experienced ∼20 TCs (post-TC). Results : In the pre-TC latent phase, both sexes exhibited leaky BBB; however...

... mimetic intervention. Metabolic control and renal injury were compared in rats undergoing a dietary restriction plus medical therapy protocol (DMT; fenofibrate, liraglutide, metformin, ramipril, and rosuvastatin) and ad libitum -fed controls. The global renal cortical transcriptome and urinary 1 H-NMR...

... correlated with cGMP levels consistent with a NEP-dependent anti-fibrotic effect. To dissect the molecular mechanisms associated with the anti-fibrotic effects of NEP inhibition, we performed a ‘deep serial analysis of gene expression (Deep SAGE)’ transcriptome and targeted metabolomics analysis of total...

... represents acute rejection, a molecular study was performed. The transcriptome of eIV ( n =6), T cell-mediated vascular rejection with rich TI (T cell-mediated vascular rejection, TCMRV, n =4) and non-rejection histologic findings ( n =8) was compared using microarrays. A total of 310 genes were identified...

... RNA surgery transcriptomics two-dimensional electrophoresis The Biochemical Society 2005 The organism reacts to surgery with a non-specific metabolic response [ 1 – 6 ]. This stress response is maintained over several days, depending on the severity of the insult. The most conspicuous...