... there is a common aetiology for these diseases. Transgenic mouse models expressing mutant proteins provide a means of gaining insight into the pathophysiological and clinical features of human cardiomyopathy. For example, transgenic mice carrying the missense mutation p.Arg403Gln in the αMHC gene, the murine...

... acetylcholine endothelial function growth factor transgenic mouse vasodilation Acromegaly, characterized by excessive secretion of GH (growth hormone), is associated with cardiovascular disease [ 1 ]. Indeed, cardiovascular events are the most common cause of death in acromegalic patients [ 2 , 3...

... The Biochemical Society and the Medical Research Society 1993 active renin anti-renin antibody inactive renin sodium depletion transgenic mouse Clinical Science (1993) 84, 21-29 (Printed in Great Britain) 21 Biochemical characteristics of human renin expressed in transgenic mice Kazuo TAKAORI...

... fibrosis transgenic mouse to be undertaken. Knowledge of normal ion transport will be necessary for the validation of any such animal model. We have therefore characterized selected responses of the murine trachea and caecum mounted in ‘mini’ Ussing chambers under open-circuit conditions. 2. Basal values...