... of translation. CKD was among the fastest growing causes of death in the past 20 years in age-adjusted terms. The gap between recent advances and the growing worldwide mortality appears to result from sequential roadblocks that limit the flow from basic research to clinical development (translational research...

... microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges...

... © The Authors Journal compilation © 2010 Biochemical Society 2010 cardiovascular disease diabetes mellitus hyperlipidaemia inflammation innate immune system periodontitis translational research The innate immune system contributes to the development of T2DM [Type 2 DM (diabetes...

... atherosclerosis endothelial function endothelial progenitor cell smooth muscle progenitor cell translational research The last decade has seen a huge interest in the field of regenerative biology, with particular emphasis on the use of isolated or purified stem and progenitor cells to try to restore...

... and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost-effective decision making in exploratory development and increase phase II success. Translational research is one of the most important activities of translational medicine as it supports predictions about...

..., Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, U.S.A. (email [email protected] ). 11 3 2005 20 4 2005 9 5 2005 The Biochemical Society 2005 biomarker genomics protein expression proteomics renal disease translational research...