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Keywords: transplantation
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Articles
Clin Sci (Lond) (2018) 132 (16): 1753–1763.
Published: 30 August 2018
..., BKPyV infection is highly prevalent amongst immunocompromised populations, yet little is known on its relationship with malignancy. We studied a female patient with BKPyV-associated and donor-derived de novo high-grade sarcomatoid urothelial carcinoma developed 8 years after kidney transplantation from...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (18): 2381–2395.
Published: 08 September 2017
... Sertoli cells in SSC enrichment; and (iii) assess the success of transplantation using in vitro differentiated SSCs in a mouse busulfan-treated azoospermia model. A 1-day-old embryoid body (EB) received 5 ng/ml of bone morphogenetic protein 4 (BMP4) for 4 days, 3 µM retinoic acid (RA) in a SIM mouse...
Articles
Clin Sci (Lond) (2017) 131 (17): 2241–2256.
Published: 10 August 2017
... data regarding the role of IL-1 cytokines in transplantation. In recent years, targeted therapeutics affecting IL-1 have been used in multiple clinical studies. In addition to the recombinant IL-1Ra, anakinra (highly effective in autoinflammatory diseases and tested for other chronic diseases), the...
Articles
Clin Sci (Lond) (2014) 127 (8): 527–537.
Published: 30 June 2014
... transplantation is partly mediated by oxidative stress and may lead to graft dysfunction. This is especially relevant when steatotic donors are considered. Using primary cultured liver sinusoidal endothelial cells (LSECs), liver grafts from healthy and steatotic rats, and human liver samples, we aimed to...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 125 (7): 319–327.
Published: 07 June 2013
...Wei Eric Wang; Xiongwen Chen; Steven R. Houser; Chunyu Zeng Stem cell therapy has emerged as a promising strategy for cardiac and vascular repair. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous...
Articles
Clin Sci (Lond) (2012) 123 (2): 93–98.
Published: 23 March 2012
... (ischaemia/reperfusion) injury in the liver. I/R is the main cause of primary liver failure and, consequently, minimizing the detrimental effects of this process could increase the number of suitable transplantation grafts and also enhance the survival rate of patients after liver transplantation. A...
Articles
Clin Sci (Lond) (2010) 118 (2): 87–97.
Published: 12 October 2009
... transplantation. Multiple groups have developed varied approaches to create a population of cells with the appropriate characteristics. Both adult and embryonic stem cells have received an enormous amount of attention as possible sources of insulin-producing cells. Although adult stem cells lack the pluripotent...
Articles
Clin Sci (Lond) (2008) 114 (3): 231–241.
Published: 08 January 2008
... stoichiometrically. These changes were irrespective of arginase-1 plasma levels and were explained by arginase activity present in intact erythrocytes. Next, plasma samples with 1000-fold normal arginase-1 concentrations were obtained from patients undergoing cadaveric liver transplantation. A significant decrease...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 206S–209S.
Published: 01 September 2002
... ET system is activated following prolonged ischaemia. In this study we used a model mimicking the conditions of the donor heart during transplantation. Isolated rat hearts perfused with Krebs–Henseleit buffer were subjected to 30min of normothermic perfusion, then 4h of cardioplegic arrest at 4°C...
Articles
Clin Sci (Lond) (2000) 99 (5): 467–472.
Published: 26 October 2000
...Martin G. BUCKLEY; Geraint H. JENKINS; Andrew G. MITCHELL; Magdi H. YACOUB; Donald R. J. SINGER C-type natriuretic peptide (CNP) is a potent, endothelial-derived relaxant and growth-inhibitory factor. Accelerated vascular disease is an important cause of morbidity in cardiac transplant recipients...
Articles
Clin Sci (Lond) (1999) 97 (3): 283–290.
Published: 15 July 1999
... suggested that it can directly alter transport processes at the plasma membrane. To examine this possibility in a physiological context, we determined Na + /K + -ATPase activity in erythrocytes from two groups of subjects receiving CsA treatment: group I consisted of kidney transplant patients, and group II...
Articles
Clin Sci (Lond) (1997) 93 (1): 81–88.
Published: 01 July 1997
...Etsuro Hatano; Tetsuya Kiuchi; Akira Tanaka; Hisashi Shinohara; Toshiyuki Kitai; Seiji Satoh; Takuya Inomoto; Hiroto Egawa; Shinji Uemoto; Yukihiro Inomata; Hauke Lang; Karl J Oldhafer; Bruckhardt Ringe; Rudolf Pichlmayr; Koichi Tanaka; Yoshio Yamaoka 1. Living-related liver transplantation has...
Articles
Clin Sci (Lond) (1997) 92 (2): 113–122.
Published: 01 February 1997
..., they cannot repair or replace the lost myelin. To this end, an additional therapy has been proposed, which involves transplanting cells of the oligodendrocyte lineage into the central nervous system. 2. The cell of interest for transplantation is the oligodendrocyte precursor because, unlike the...
Articles
Clin Sci (Lond) (1996) 91 (3): 319–327.
Published: 01 September 1996
...Annick Buvry; Monique Garbarg; Violetta Dimitriadou; Agnès Rouleau; George F. J. Newlands; Reza Tavakoli; Virginie Poaty; Alain Lockhart; Jean-Charles Schwartz; Nelly Frossard 1. Lung transplantation causes a total interruption of the innervation and vascularization within the transplanted organ...
Articles
Clin Sci (Lond) (1987) 72 (3): 283–287.
Published: 01 March 1987
... lung was studied in five human heart–lung transplant recipients. 2. AH five patients showed significant increases in mean pulmonary artery pressure and pulmonary vascular resistance during hypoxic exposure, returning toward normoxic values during recovery. Aside from P ao 2 and P ao 2 , other factors...
Articles
Clin Sci (Lond) (1986) 70 (5): 443–452.
Published: 01 May 1986
...Susan C. Pirie; D. J. Potts 1. Rabbits were anaesthetized and kidneys removed directly with no flush (group NF), or alternatively kidneys were flushed (group F) with sodium phosphate buffered 140 mmol/1 sucrose (PBsuc 140), Collins C 2 (C 2 ) or Euro-Collins (EC) transplant preservation solutions...
Articles
Clin Sci (Lond) (1981) 61 (1): 69–73.
Published: 01 July 1981
...J. Cunningham; M. J. Vandenburg; J. M. P. Holly; F. J. Goodwin 1. Changes in plasma renin activity, plasma noradrenaline, pulse rate and blood pressure after tilting were measured in normal subjects and in patients with renal transplants. 2. There was a marked difference between the renin responses...
Articles
Clin Sci Mol Med (1976) 51 (s3): 227s–230s.
Published: 01 December 1976
...J. S. Horvath; C. Baxter; F. Furby; V. Hood; J. Johnson; B. McGrath; D. J. Tiller 1. Patients with cadaveric renal transplants and plasma creatinine less than 177 μmol/l who had their own kidneys removed were studied. 2. The renin—angiotensin system appeared to behave in a normal fashion in...
Articles
Clin Sci Mol Med (1974) 47 (3): 235–248.
Published: 01 September 1974
... patients. Five patients were also studied before nephrectomy and six after successful renal transplantation. 2. Before nephrectomy, the resting concentrations of plasma aldosterone were usually raised. In the three patients out of five tested, the response to intravenous ACTH was marked. In two out of four...