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Keywords: transthyretin
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Articles

TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines

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João Moreira, Helena Martins, Margarida Saraiva, Maria João Saraiva
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (5): 355–366.
https://doi.org/10.1042/CS20220656
Published: 09 March 2023
...João Moreira; Helena Martins; Margarida Saraiva; Maria João Saraiva Hereditary amyloid transthyretin (ATTRv) amyloidosis is a fatal neurodegenerative disorder, first identified in Portugal. The most common transthyretin (TTR) mutation in ATTRv results from an exchange of a methionine for a valine...
View articletitled, TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines
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Includes: Supplementary data
Articles

Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin

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Cristina A. Teixeira, Maria do Rosário Almeida, Maria João Saraiva
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1665–1675.
https://doi.org/10.1042/CS20160075
Published: 08 August 2016
...Cristina A. Teixeira; Maria do Rosário Almeida; Maria João Saraiva Transthyretin (TTR)-related amyloidoses are diseases characterized by extracellular deposition of amyloid fibrils and aggregates in tissues composed of insoluble misfolded TTR that becomes toxic. Previous studies have demonstrated...
View articletitled, Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin
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