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Clin Sci (Lond) (2018) 132 (13): 1403–1415.
Published: 09 July 2018
... the progression of renal fibrosis in a mouse model of unilateral ureteral obstructive nephropathy (UUO). We found that preventive treatment with SIS3 at the time of disease induction largely suppressed progressive renal fibrosis by inhibiting α-smooth muscle actin (α-SMA) + myofibroblast accumulation...
Stella Bernardi, Giorgio Zauli, Christos Tikellis, Riccardo Candido, Bruno Fabris, Paola Secchiero, Mark E. Cooper, Merlin C. Thomas
Clin Sci (Lond) (2012) 123 (9): 547–555.
Published: 13 July 2012
... injection. Body composition was evaluated; indirect calorimetry studies, GTT (glucose tolerance test) and ITT (insulin tolerance test) were performed. Pro-inflammatory cytokines, together with adipose tissue gene expression and apoptosis, were measured. TRAIL treatment reduced significantly the increased...
Clin Sci (Lond) (2006) 110 (3): 267–278.
Published: 10 February 2006
... to illuminate the in vivo pathophysiological significance of this protein. Although evaluation of adiponectin as a novel therapy will ultimately require clinical intervention studies, this mediator may represent a novel target for the prevention and treatment of visceral obesity metabolic syndrome...
Clin Sci (Lond) (2006) 110 (1): 73–88.
Published: 12 December 2005
...Olivia J. Handley; Jenny J. Naji; Stephen B. Dunnett; Anne E. Rosser HD (Huntington's disease) is a devastating neurodegenerative disorder caused by a polyglutamine expansion in the gene encoding the huntingtin protein. Presently, there is no known cure for HD and existing symptomatic treatments...
Clin Sci (Lond) (2005) 108 (1): 23–36.
Published: 15 December 2004
... to overt HF. The BNP peptides also predict subsequent haemodynamic deterioration and adverse events in cardiovascular disease, and can therefore be used to monitor those at high risk and act as a guide to optimization of treatment. The favourable biological properties of the natriuretic peptides have...
Clin Sci (Lond) (2004) 107 (6): 539–557.
Published: 24 November 2004
... failure. Although a range of diagnostic methods may help to characterize alterations in cardiac function in general, none are specific for the alterations in diabetes. Treatment paradigms are very much limited to interpretation and translation from the results of interventions in non-diabetic patients...
Clin Sci (Lond) (1998) 95 (3): 325–329.
Published: 01 September 1998
... diabetes, six patients were entered into a 6-week, double-blind crossover trial during which each received 3 weeks treatment with subcutaneous GLP-1 or saline, self-administered three times a day immediately before meals. A standard test meal was given at the beginning and end of each treatment period. 3...
Clin Sci (Lond) (1996) 90 (3): 227–234.
Published: 01 March 1996
... lung function. 2. Twelve subjects whose asthma was inadequately controlled by inhaled bronchodilator alone were studied during four different drug treatments over 3 months. Subjective self-assessment of asthma was scored on a 10 cm visual analogue scale and followed by three consecutive measurements of...
Clin Sci Mol Med (1976) 51 (s3): 657s–659s.
Published: 01 December 1976
...C. Hodes; P. A. Rogers; M. G. Everitt 1. A screening programme has been set up in a group general practice for identifying and treating moderate high blood pressure in men and women aged 45–54 years, and at the same time the identification and treatment of high blood pressure in patients in...