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Keywords: tumour microenvironment
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Clin Sci (Lond) (2021) 135 (1): 35–52.
Published: 05 January 2021
...Jitske van den Bulk; Noel F.C.C. de Miranda; Peter ten Dijke Cancers may escape elimination by the host immune system by rewiring the tumour microenvironment towards an immune suppressive state. Transforming growth factor-β (TGF-β) is a secreted multifunctional cytokine that strongly regulates...
Clin Sci (Lond) (2020) 134 (12): 1377–1397.
Published: 18 June 2020
... be likened as a group performance concert rather than a solo concert. Tumours consist of not only cancer cells but also multiple distinct cell types that are either resident or infiltrating host cells that interact with one another and comprise the tumour microenvironment (TME) [ 132 ]. TME is composed...
Clin Sci (Lond) (2018) 132 (18): 2029–2044.
Published: 19 September 2018
.... In the present study, we explored the effect of exosomes on cells present in the tumour microenvironment. Exosomes were isolated from ovarian cancer cells with different invasive capacity (high = SKOV-3 and low = OVCAR-3) by differential and buoyant density centrifugation and characterised using nanoparticle...
Includes: Supplementary data