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Keywords: tumour necrosis factor
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Articles
Clin Sci (Lond) (2013) 125 (3): 131–141.
Published: 12 April 2013
...-induced vascular hyporeactivity, suggesting different signalling pathways between IL-1β and NOS (NO synthase). LPS-induced plasma levels of IL-1β, TNFα (tumour necrosis factor α), IL-10, vascular eNOS (endothelial NOS) and COX2 (cyclo-oxygenase 2) protein expression, as determined by ELISA and Western...
Articles
Clin Sci (Lond) (2005) 108 (3): 255–263.
Published: 18 February 2005
... be activated by FVIIa (activated FVII) and induce ET-1 (endothelin-1) synthesis. In bovine aortic endothelial cells pretreated with TNF (tumour necrosis factor-α) to increase TF expression, FVIIa stimulated ET-1 synthesis via activation of PAR2. Although FX (factor X) alone was inactive, this response...
Articles
Clin Sci (Lond) (2003) 104 (5): 493–501.
Published: 01 May 2003
... approaches are presented together with future prospects for in vivo analysis. The strategic application of these functional approaches is discussed and illustrated by analysis of the role of genetic variation in the tumour necrosis factor promoter region in determining susceptibility to severe malaria...
Articles
Clin Sci (Lond) (2002) 103 (2): 163–169.
Published: 17 July 2002
...William BILSBOROUGH; Gerard O'DRISCOLL; Kim STANTON; Rukshen WEERASOORIYA; Lawrence DEMBO; Roger TAYLOR; Daniel GREEN Tumour necrosis factor-α (TNFα) is a mediator of reactive oxygen species, which are implicated in endothelial dysfunction and atherosclerosis. Type II diabetes is associated...
Articles
Clin Sci (Lond) (1999) 97 (1): 85–89.
Published: 01 June 1999
...P. C. TAYLOR; A. M. PETERS; D. M. GLASS; R. N. MAINI The therapeutic effects of a monoclonal antibody against tumour necrosis factor α (TNFα) were evaluated objectively in 10 patients with rheumatoid arthritis by 111 In-labelled granulocyte imaging before and after treatment, and compared...
Articles
Clin Sci (Lond) (1999) 96 (3): 287–295.
Published: 01 March 1999
... that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1β, tumour necrosis factor-α and C-reactive protein were...
Articles
Clin Sci (Lond) (1998) 95 (3): 347–354.
Published: 01 September 1998
... were also studied. 2. Incubation of PBMCs with interleukin-4 significantly reduced both spontaneous and lipopolysaccharide-induced production of tumour necrosis factor and lipopolysaccharide-induced interleukin-6 production, demonstrating that the PBMCs from patients with acute and chronic disease...
Articles
Clin Sci (Lond) (1996) 91 (2): 121–130.
Published: 01 August 1996
...Robert F. Grimble © 1996 The Biochemical Society and the Medical Research Society 1996 amino acids antioxidants cytokines fats glutathione inflammation interleukin nutrition tumour necrosis factor vitamin E Clinical Science (1996) 91, 121-130 (Printed i n Great Britain...
Articles
Clin Sci (Lond) (1995) 88 (4): 485–489.
Published: 01 April 1995
... necrosis factor production, plasma interleukin-6 and acute-phase protein concentration and antioxidant vitamins in smokers and non-smokers. 2. Measurement of tumour necrosis factor was conducted in whole blood stimulated with endotoxin (lipopolysaccharide), and interleukin-6 concentrations were measured...
Articles
Clin Sci (Lond) (1995) 88 (2): 211–217.
Published: 01 February 1995
...A. Brouwer; S. G. Parker; H. F. J. Hendriks; L. Gibbons; M. A. Horan 1. The clinicopathological features of endotoxaemia have been ascribed to cytotoxic mediators such as tumour necrosis factor, interleukins and eicosanoids. Macrophages, particularly Kupffer cells, are an important source...
Articles
Clin Sci (Lond) (1994) 87 (3): 349–355.
Published: 01 September 1994
... as an increase in circulating triacylglycerol levels, whereas no changes were observed in glycaemia. 3. Tumour-bearing rats were treated with a polyclonal anti-murine tumour necrosis factor-α antibody or with a non-immune IgG preparation. Control animals were either untreated or received a nonimmune IgG...
Articles
Clin Sci (Lond) (1994) 87 (2): 173–178.
Published: 01 August 1994
... and butter for 4 and 8 weeks on subsequent cytokine production by peritoneal macrophages of rats. 4. Tumour necrosis factor production in response to a lipopolysaccharide stimulus and interleukin-1 and interleukin-6 production in response to a tumour necrosis factor challenge were studied. 5. All fats...
Articles
Clin Sci (Lond) (1994) 86 (5): 633–638.
Published: 01 May 1994
...Felix Stockenhuber; Michaela Keil; Christian Wurnig; Robert W. Kurz; Michael Gottsauner-Wolf; Peter Balcke 1. Serum levels of erythropoietin and the immune parameters tumour necrosis factor-α, soluble interleukin-2 receptor, interleukin-2, interleukin-6 and interferon-γ were measured in patients...
Articles
Clin Sci (Lond) (1994) 86 (4): 461–467.
Published: 01 April 1994
...U. Süttmann; O. Selberg; H. Gallati; J. Ockenga; H. Deicher; M. J. Müller 1. Increased release of tumour necrosis factor is thought to contribute to human-immunodeficiency-virus-associated wasting syndrome. Elevated serum concentrations of tumour necrosis factor have, however, mainly been found...
Articles
Clin Sci (Lond) (1994) 86 (3): 347–351.
Published: 01 March 1994
...J. F. Doherty; M. H. N. Golden; D. G. Remick; G. E. Griffin 1. Cytokine production in vitro was assessed in 16 malnourished children, before and after nutritional recovery. 2. Tumour necrosis factor-α and interleukin-6 were measured in whole blood after lipopolysaccharide stimulation. 3. The total...
Articles
Clin Sci (Lond) (1993) 84 (3): 349–356.
Published: 01 March 1993
...Tsukasa Nakamura; Isao Ebihara; Mitsumine Fukui; Toshimasa Takahashi; Yasuhiko Tomino; Hikaru Koide 1. We determined glomerular and medullary tumour necrosis factor-α mRNA levels in acute puromycin aminonucleoside nephrosis on days 0, 8 and 20. 2. Tumour necrosis factor-α mRNA levels were increased...
Articles
Clin Sci (Lond) (1993) 84 (2): 243–246.
Published: 01 February 1993
...P. Jeremy McLaughlin; Atsushi Alkawa; Helen M. Davies; Richard G. Ward; Ali Bakran; Robert A. Sells; Peter M. Johnson 1. Uromodulin, an immunosuppressive glycoprotein found in urine, is a high-affinity binding ligand for certain cytokines, including tumour necrosis factor. 2. Its occurrence...
Articles
Clin Sci (Lond) (1992) 82 (2): 205–209.
Published: 01 February 1992
...Rhys D. Evans; Vera Ilic; Dermot H. Williamson 1. Administration of tumour necrosis factor (cachectin) and of interleukin-1-α increased the plasma level of non-esterified fatty acids in fed rats, and in the case of interleukin-1-α the blood glycerol level was also increased, suggesting stimulation...
Articles
Clin Sci (Lond) (1991) 80 (4): 359–365.
Published: 01 April 1991
... 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 acquired immunodeficiency syndrome fasting glucose lipolysis non-esterified fatty acids triacylglycerols tumour necrosis factor Clinical Science (1991) 80,359-365 359 Basal fuel homoeostasis in symptomatic...
Articles
Clin Sci (Lond) (1990) 79 (6): 657–662.
Published: 01 December 1990
...David C. Bibby; Robert F. Grimble 1. The primary aim of the study was to determine whether the stimulatory effect of tumour necrosis factor-α and endotoxin on hypothalamic prostaglandin E 2 production was influenced by dietary fats containing different amounts of linoleic acid. Rats received diets...
Articles
Clin Sci (Lond) (1989) 77 (1): 35–41.
Published: 01 July 1989
...%. Preincubation of control subjects' neutrophils with plasma from emphysematous patients had no effect on fibronectin digestion. 2. Tumour necrosis factor increased fibronectin digestion in a dose-dependent manner when the cytokine was added to the adherent cells but not when preincubated...
Articles
Clin Sci (Lond) (1988) 75 (3): 251–255.
Published: 01 September 1988
...J. R. Weinberg; D. J. M. Wright; A. Guz 1. The cardiovascular effects of intravenous injections of interleukin-1 (IL-1) and tumour necrosis factor (TNF) have been investigated in the conscious rabbit. They have been compared with the effects of bacterial lipopolysaccharide (LPS) because both IL-1...