... participate in the development and/or maintenance of hyperdynamic circulation. 24 1 1997 8 5 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 cirrhosis endotoxin hyperdynamic circulation nitric oxide portal hypertension tumour necrosis factor-α Clinical...

... an inflammatory challenge by intraperitoneal injection of tumour necrosis factor-α or endotoxin (lipopolysaccharide). 3. Diets containing 200 g of casein and 8 g of l-cysteine/kg (normal-protein diet), or 80 g of casein and 8 g of l-cysteine, or isonitrogenous amounts of l-methionine or l-alanine (low-protein...

... necrosis factor-α production and since this cytokine may induce vasodilatation per se , a pentoxifylline-induced decrease in tumour necrosis factor-α production may limit arterial vasodilatation and decrease portal pressure. The aim of the present study was to examine the effects of pentoxifylline...

...Helen M. Keane; Nick Sheron; John Goka; Robin D. Hughes; Roger Williams 1. Soluble tumour necrosis factor receptors released into the circulation inhibit the effects of excess tumour necrosis factor-α and represent an important protective response. 2. In this study we have measured the levels...

...R. Koopmans; F. J. Hoek; S. J. H. van Deventer; T. van der Poll 1. Tumour necrosis factor-α is considered an important mediator in the pathophysiology of several diseases. Although much information is available about the serum concentrations of this cytokine in these illnesses, little is known...

...J. Stuart Elborn; Sally M. Cordon; Philip J. Western; Ian A. MaCdonald; Dennis J. Shale 1. We investigated the relationship between circulating tumour necrosis factor-α concentrations, resting energy expenditure, cachexia and altered intermediary metabolism in patients with cystic fibrosis...

...Hilda M. Mulrooney; Robert F. Grimble 1. Tumour necrosis factor-α is produced in response to inflammatory stimuli. Fish oil can suppress the production and actions of cytokines. Little information is available on the effects of other fats on cytokine biology. We compared the effects of fats...

...Kazuhiro Takahashi; Ayona Silva; Jonathan Cohen; Hing-Chung Lam; Mohammad A. Ghatei; Stephen R. Bloom 1. To investigate the role of endothelin in Gram-negative bacteraemia and the possible involvement of tumour necrosis factor-α in its pathophysiology, we measured plasma and tissue (lung, kidney...