...S. J. Rupert Vessey; Philip M. Jones; Simon C. Wallis; John Schofield; Stephen R. Bloom 1. Activating mutations of the α-subunits of the G s and G i 2 proteins give rise to the oncogenes gsp and gip2 , respectively, which are found in a variety of endocrine tumours. 2. In this study the polymerase...

...S. D. Heys; K. G. M. Park; M. A. McNurlan; A. G. Calder; V. Buchan; K. Blessing; O. Eremin; P. J. Garlick 1. A method is described for measuring the rates of protein synthesis in vivo in human colorectal and breast tumours by the intravenous injection of l -[1- 13 C]leucine as a ‘flooding dose'. 2...

...D. A. Kelly; J. M. Scott; D. G. Weir 1. Folate deficiency is reported in association with certain malignant tumours, and it has been suggested that this arises from increased folate turnover and catabolism in such circumstances. 2. Using an experimental animal model to determine the rate...