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Keyword: type 2 diabetes
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Articles
Clin Sci (Lond) (2019) 133 (22): 2317-2327.
Published: 26 November 2019
...Nicolás Gómez-Banoy; James C. Lo The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act as an...
Articles
Clin Sci (Lond) (2019) 133 (21): 2121-2141.
Published: 06 November 2019
... Kantharidis ( phillip.kantharidis@monash.edu ) 12 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes...
Articles
Clin Sci (Lond) (2019) 133 (19): 2029-2044.
Published: 14 October 2019
... Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Apoptosis CVX343 Insulin Islets Obesity Type 2 diabetes Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and hyperlipidemia. Most patients with T2DM...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (15): 1705-1720.
Published: 02 August 2019
...Mei Xue; Ting Li; Yue Wang; Yunpeng Chang; Ying Cheng; Yunhong Lu; Xiangyang Liu; Linxin Xu; Xiaoyu Li; Xiaochen Yu; Bei Sun; Liming Chen Cardiovascular complications contribute to the major mortality and morbidity in type 2 diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized as an...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (13): 1367-1386.
Published: 01 July 2019
...Hiranya Pintana; Grazyna Lietzau; Ingrid Lovise Augestad; Fausto Chiazza; Thomas Nyström; Cesare Patrone; Vladimer Darsalia Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2451-2467.
Published: 30 November 2018
... 2018 25 09 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 exosomes Insulin sensitivity microRNA pregnancy type 2 diabetes Maternal metabolism undergoes dynamic changes in pregnancy to ensure an adequate supply of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (20): 2207-2220.
Published: 23 October 2018
...Sara Baqar; Dorothy Liu; Lisa F. Lincz; Yee Wen Kong; George Jerums; Elif I. Ekinci Objective: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin–angiotensin–aldosterone system (RAAS) activation...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (15): 1699-1709.
Published: 16 August 2018
...James G. Boyle; Rachel Livingstone; John R. Petrie Type 2 diabetes (T2D) carries risks of both cardiovascular (CV) (myocardial infarction, stroke, and peripheral vascular disease) and microvascular (retinopathy/nephropathy/neuropathy) complications. Glucose-lowering is an effective strategy for...
Articles
Clin Sci (Lond) (2018) 132 (15): 1629-1643.
Published: 14 August 2018
... pluripotent stem cells type 2 diabetes Wound healing Diabetes mellitus is a major global health concern, affecting approximately 425 million adults worldwide, a figure predicted to rise to 629 million people with diabetes by 2045 (International Diabetes Federation). Type 1 diabetes mellitus (T1DM...
Articles
Clin Sci (Lond) (2018) 132 (10): 1039-1054.
Published: 25 May 2018
... 23 03 2018 23 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (4): 489-507.
Published: 28 February 2018
...Keizo Kanasaki Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors used to treat type 2 diabetes may have nephroprotective effects beyond the reduced renal risk conferred by glycemic control. DPP-4 is a ubiquitous protein with exopeptidase activity that exists in cell membrane...
Articles
Clin Sci (Lond) (2018) 132 (2): 213-229.
Published: 19 January 2018
... protein 1 (Ninj1) is an adhesion molecule that not only contributes to inflammation but also regulates the apoptosis of endothelial cells. In the present study, Ninj1 was found highly expressed in endothelial cells in Type 2 diabetic mice and increased in high-glucose (HG) cultured HUVECs. Furthermore, we...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (1): 69-83.
Published: 05 January 2018
... diabetes. It has been shown that TRAIL deficiency worsens diabetes and that TRAIL delivery, when it is given before disease onset, slows down its development. The present study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat type 2 diabetes. Thirty male C57BL/6J...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1905-1917.
Published: 07 July 2017
...Bram Brouwers; Vera B. Schrauwen-Hinderling; Tomas Jelenik; Anne Gemmink; Bas Havekes; Yvonne Bruls; Dennis Dahlmans; Michael Roden; Matthijs K.C. Hesselink; Patrick Schrauwen Non-alcoholic fatty liver (NAFL) is an independent risk factor for the development of type 2 diabetes (T2DM). We examined...
Articles
Clin Sci (Lond) (2017) 131 (10): 991-1000.
Published: 09 May 2017
...Ashish Patidar; Dhruv K. Singh; Shori Thakur; Peter Winocour; Ken Farrington; Anwar R. Baydoun Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum...
Articles
Clin Sci (Lond) (2017) 131 (5): 343-353.
Published: 15 February 2017
... expresses the GLP-1 receptor (GLP-1R). The present study aimed to assess the impact of GLP-1 analogue treatment on subcutaneous AT (SCAT) inflammatory and fibrotic responses, compared with weight loss by calorie reduction (control). Among the 39 participants with Type 2 diabetes recruited, 30 age-matched...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (1): 37-47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (1): 45-56.
Published: 30 November 2015
... contributes to delaying wound healing. B 2 receptor blockade restores the normal wound healing pattern in mouse models of diabetes. bradykinin receptors kallikrein–kinin system skin wound healing Type 1 diabetes Type 2 diabetes • Impairment of skin wound repair is a major complication of...
Articles
Clin Sci (Lond) (2015) 129 (5): 415-422.
Published: 11 June 2015
... aldosterone level and estimated glomerular filtration rate (eGFR) in hypertensive patients with type 2 diabetes. In a randomized, double-blind, placebo-controlled study (RCT), 28 patients with type 2 diabetes, treated with telmisartan (40 mg daily), received 2 weeks of placebo or NaCl capsules (100 mmol/24 h...
Articles
Clin Sci (Lond) (2015) 128 (10): 707-713.
Published: 27 February 2015
...Mavin Macauley; Fiona E Smith; Peter E Thelwall; Kieren G Hollingsworth; Roy Taylor; Roy Taylor Storage of food-derived glucose as muscle and liver glycogen is vital to avoid damaging swings plasma osmolarity. We report that in Type 2 diabetes, muscle glycogen storage was completely inactive...
Articles
Clin Sci (Lond) (2015) 128 (7): 405-410.
Published: 09 December 2014
...Roy Taylor; Rury R. Holman Type 2 diabetes (T2DM) is frequently regarded as a disease of obesity and its occurrence in individuals of normal body mass index (BMI) is often regarded as indicating a non-obesity-related subtype. However, the evidence for such a distinct, common subtype is lacking. The...
Articles
Clin Sci (Lond) (2015) 128 (7): 411-423.
Published: 09 December 2014
... (db/db) mice, a model of Type 2 diabetes and control Lepr db /Lepr + (db/+) mice were administered atorvastatin (10 mg/kg per day, 2 weeks). Atorvastatin improved glucose tolerance in db/db mice. Systemic and vascular oxidative stress in db/db mice, characterized by increased plasma TBARS...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (12): 665-677.
Published: 08 August 2014
... Boscá; María Fernández-Velasco Type 2 diabetes has a complex pathology that involves a chronic inflammatory state. Emerging evidence suggests a link between the innate immune system receptor NOD1 (nucleotide-binding and oligomerization domain 1) and the pathogenesis of diabetes, in monocytes and hepatic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (2): 91-100.
Published: 17 March 2014
... the present study was to investigate the role of GdCl 3 in hepatic gluconeogenesis and explore the precise molecular mechanism. Animals from a classical Type 2 diabetic mouse model, created by exposing C57BL/6J mice to a high-fat diet for 4 months, were treated with GdCl 3 or saline. Body weight...
Articles
Clin Sci (Lond) (2014) 126 (10): 739-752.
Published: 03 February 2014
... β-cell failure. aging extracellular heat-shock protein 72 (eHSP72) insulin resistance pancreatic β-cell Type 1 diabetes Type 2 diabetes • eHSP72 is increased in the plasma of both types of diabetes and is positively correlated with inflammatory markers; however, no studies have...
Articles
Clin Sci (Lond) (2013) 125 (8): 383-389.
Published: 14 June 2013
...Pam R. Taub; Israel Ramirez-Sanchez; Theodore P. Ciaraldi; Silvia Gonzalez-Basurto; Ramon Coral-Vazquez; Guy Perkins; Michael Hogan; Alan S. Maisel; Robert R. Henry; Guillermo Ceballos; Francisco Villarreal HF (heart failure) and T2D (Type 2 diabetes) associate with detrimental alterations in SkM...
Articles
Clin Sci (Lond) (2013) 125 (6): 301-310.
Published: 22 May 2013
... countries and share multiple risk factors. The relationship between NAFLD and AF in Type 2 diabetes is currently unknown. We studied a hospital-based sample of 702 patients with Type 2 diabetes discharged from our Division of Endocrinology during 2007–2011. The diagnosis of AF was confirmed in affected...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 125 (4): 167-182.
Published: 26 April 2013
...Karen E. Porter; Kirsten Riches The rising epidemic of T2DM (Type 2 diabetes mellitus) worldwide is of significant concern. The inherently silent nature of the disease in its early stages precludes early detection; hence cardiovascular disease is often established by the time diabetes is diagnosed...
Articles
Clin Sci (Lond) (2012) 123 (6): 375-386.
Published: 29 May 2012
... aortas than in their controls, but the total PP1α protein level was not different. These results suggest that the aortic relaxation responses, NO production, and eNOS activity mediated by CaMKII phosphorylation are decreased in this Type 2 diabetic model, and that these impairments of CaMKII signalling...
Articles
Clin Sci (Lond) (2012) 122 (6): 253-270.
Published: 11 November 2011
...-line oral therapy for T2D (Type 2 diabetes). The main effect of this drug from the biguanide family is to acutely decrease hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory chain complex I. In addition, the resulting decrease in hepatic energy...
Articles
Clin Sci (Lond) (2012) 122 (5): 203-214.
Published: 28 October 2011
... compilation © 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36 million in the U.S.A. [ 1 , 2 ]. The prevalence of diabetes is increasing...
Articles
Clin Sci (Lond) (2011) 121 (4): 169-177.
Published: 04 May 2011
..., but no direct measurement has tested this concept or its possible relationship to the reported impairment in insulin-stimulated muscle ATP production. Isoglycaemic–hyperinsulinaemic clamps with [ 13 C]glucose infusion were performed on Type 2 diabetic subjects and matched controls with measurement of...
Articles
Clin Sci (Lond) (2011) 120 (10): 463-472.
Published: 28 January 2011
...Adriana Georgescu; Doina Popov; Anamaria Constantin; Miruna Nemecz; Nicoleta Alexandru; Daniel Cochior; Aura Tudor The aim of the present study was to examine the effects of obesity alone and obesity associated with Type 2 diabetes on the structure, vascular reactivity and response to insulin of...
Articles
Clin Sci (Lond) (2010) 119 (7): 293-301.
Published: 25 June 2010
... 3 2010 20 4 2010 13 5 2010 13 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cardiometabolic risk-factor exercise training insulin sensitivity mitochondrial function statin Type 2 diabetes Hyperlipidaemia and hyperglycaemia are...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 118 (10): 607-615.
Published: 23 February 2010
...Sandra J. Hamilton; Gerard T. Chew; Timothy M.E. Davis; Gerald F. Watts Dyslipidaemia contributes to endothelial dysfunction and CVD (cardiovascular disease) in Type 2 diabetes mellitus. While statin therapy reduces CVD in these patients, residual risk remains high. Fenofibrate corrects atherogenic...
Articles
Clin Sci (Lond) (2009) 117 (5): 173-190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
Articles
Clin Sci (Lond) (2009) 116 (10): 741-760.
Published: 15 April 2009
... Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. diabetic cardiomyopathy heart failure hyperglycaemia Type 2 diabetes...
Articles
Clin Sci (Lond) (2009) 116 (7): 565-574.
Published: 02 March 2009
...: Professor Nigel J. Brunskill (email njb18@le.ac.uk ). 1 9 2008 1 10 2008 15 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 C-peptide G-protein-coupled receptor proinsulin Type 1 diabetes Type 2 diabetes Diabetes is a disease of increasing...
Articles
Clin Sci (Lond) (2009) 116 (2): 113-123.
Published: 15 December 2008
... understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors...
Articles
Clin Sci (Lond) (2009) 116 (2): 99-111.
Published: 15 December 2008
...Wanzhu Jin; Mary-Elizabeth Patti T2DM (Type 2 diabetes mellitus) has reached epidemic proportions worldwide, exerting major health consequences at an individual and public health level alike. Unfortunately, the molecular pathophysiology of diabetes remains incompletely understood, impairing...
Articles
Clin Sci (Lond) (2009) 116 (1): 81-86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
Articles
Clin Sci (Lond) (2009) 116 (1): 17-26.
Published: 28 November 2008
... homoeostasis, cell proliferation, inflammation, reproduction and renoprotection. A large body of research over the past decade has revealed that, in addition to their insulin-sensitizing effects, TZDs play an important role in delaying and preventing the progression of chronic kidney disease in Type 2 diabetes...
Articles
Clin Sci (Lond) (2008) 115 (11): 327-334.
Published: 03 November 2008
...-II ( UTS2 ) is associated with the onset of Type 2 diabetes and insulin resistance in the Japanese population. In the present study, we have demonstrated a relationship between plasma U-II levels and the progression of diabetic retinopathy and vascular complications in patients with Type 2 diabetes...
Articles
Clin Sci (Lond) (2008) 115 (9): 273-281.
Published: 01 October 2008
... fitness in patients with Type 2 diabetes, and to identify and establish criteria for patients who are more likely to improve their blood glucose from short-term exercise training. A randomized, controlled trial of exercise training, comprising two supervised and one non-supervised sessions of...
Articles
Clin Sci (Lond) (2008) 115 (8): 255-262.
Published: 12 September 2008
...Yu-Sok Kim; Rogier V. Immink; Wim J. Stok; John M. Karemaker; Niels H. Secher; Johannes J. van Lieshout Type 2 diabetes is associated with an increased risk of endothelial dysfunction and microvascular complications with impaired autoregulation of tissue perfusion. Both microvascular disease and...
Articles
Clin Sci (Lond) (2008) 114 (9): 589-590.
Published: 02 April 2008
... 2008 glucagon glucose tolerance insulin deficiency kidney microalbuminuria Type 2 diabetes The existence of a second pancreatic hormone, one that raises plasma glucose concentrations, in addition to the glucose-lowering hormone insulin was deduced early in the 20th century and fully...
Articles
Clin Sci (Lond) (2008) 114 (9): 591-601.
Published: 02 April 2008
...Xiao C. Li; Tang-dong Liao; Jia L. Zhuo Clinical studies have shown that patients with early Type 2 diabetes often have elevated serum glucagon rather than insulin deficiency. Imbalance of insulin and glucagon in favouring the latter may contribute to impaired glucose tolerance, persistent...
Articles
Clin Sci (Lond) (2008) 114 (4): 313-320.
Published: 15 January 2008
...Piyush M. Srivastava; Paul Calafiore; Richard J. Macisaac; Sheila K. Patel; Merlin C. Thomas; George Jerums; Louise M. Burrell The aim of the present study was to determine the prevalence and predictors of an abnormal echocardiogram in patients with Type 2 diabetes. Cardiac function and structure...
Articles
Clin Sci (Lond) (2008) 114 (3): 251-256.
Published: 08 January 2008
... the aim of the present study was to compare the antioxidant capacities and structural changes in albumin in patients with T2DM (Type 2 diabetes mellitus) treated with MET (metformin) or SU (sulfonylureas) and in healthy control subjects. Structural changes in albumin were studied by fluorescence...
Articles
Clin Sci (Lond) (2008) 114 (1): 65-71.
Published: 30 November 2007
... muscle and fat tissues might generate novel strategies for the treatment of Type 2 diabetes. Correspondence: Dr Nils Welsh (email Nils.Welsh@mcb.uu.se ). 4 4 2007 20 7 2007 25 7 2007 25 7 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008...