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Distinct effects of obesity and diabetes on the action potential waveform and inward currents in rat ventricular myocytes

Anatoliy Shmygol, Gilles Bru-Mercier, Ahmed S. Sultan, Frank C. Howarth

Clin Sci (Lond) (2025) 139 (1): 55–67.

https://doi.org/10.1042/CS20242144

Published: 15 January 2025

...Anatoliy Shmygol; Gilles Bru-Mercier; Ahmed S. Sultan; Frank C. Howarth Obesity is a significant global health challenge, increasing the risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease. Research indicates that obese individuals, regardless of their diabetic status...

View articletitled, Distinct effects of obesity and diabetes on the action potential waveform and inward currents in rat ventricular myocytes

Articles

Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis

Roy Taylor, Alison C. Barnes, Kieren G. Hollingsworth, Keaton M. Irvine, Alexandra S. Solovyova, Lucy Clark, Tara Kelly, Carmen Martin-Ruiz, Davide Romeres, Albert Koulman, Claire M. Meek, Benjamin Jenkins, Claudio Cobelli, Rury R. Holman

Clin Sci (Lond) (2023) 137 (16): 1333–1346.

https://doi.org/10.1042/CS20230586

Published: 31 August 2023

... thresholds for lipid overspill and adverse effects on β-cell function. To test this hypothesis, people with Type 2 diabetes and body mass index <27kg/m 2 ( n = 20) underwent repeated 5% weight loss cycles. Metabolic assessments were carried out at stable weight after each cycle and after 12 months...

View articletitled, Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis

Includes: Supplementary data

Articles

Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms

Kalie L. Tommerdahl, Jessica Kendrick, Robert G. Nelson, Petter Bjornstad

Clin Sci (Lond) (2022) 136 (21): 1471–1483.

https://doi.org/10.1042/CS20210627

Published: 02 November 2022

...Kalie L. Tommerdahl; Jessica Kendrick; Robert G. Nelson; Petter Bjornstad Type 2 diabetes (T2D) is a global health pandemic with significant humanitarian, economic, and societal implications, particularly for youth and young adults who are experiencing an exponential rise in incident disease. Youth...

View articletitled, Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms

Articles

Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment

Shaimaa Nasr Amin

Clin Sci (Lond) (2021) 135 (4): 593–595.

https://doi.org/10.1042/CS20201297

Published: 18 February 2021

... 2020 07 02 2021 10 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cognition hippocampus mitochondria Platelets type 2 diabetes The mitochondria, the cellular organelles concerned with energy and regulating Ca 2...

View articletitled, Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment

Articles

Diabetes mellitus: a primary metabolic disturbance. Metabolomics underlying vascular responses to stress and ischemia?

In Collection

Celebrating 100 years of insulin research

Evangelos Oikonomou, Costas Tsioufis, Dimitris Tousoulis

Clin Sci (Lond) (2021) 135 (3): 589–591.

https://doi.org/10.1042/CS20201299

Published: 10 February 2021

... 2021 cardiovascular disease Metabolites type 2 diabetes Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and defect in metabolism of energy substrate—carbohydrate, fat and protein [ 1 ]. Most organs and systems are affected including brain, heart, kidney, eyes...

View articletitled, Diabetes mellitus: a primary metabolic disturbance. Metabolomics underlying vascular responses to stress and ischemia?

Articles

Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress

In Collection

Celebrating 100 years of insulin research

Joshua A. Beckman, Jiun-Ruey Hu, Shi Huang, Eric Farber-Eger, Quinn S. Wells, Thomas J. Wang, Robert E. Gerszten, Jane F. Ferguson

Clin Sci (Lond) (2020) 134 (17): 2369–2379.

https://doi.org/10.1042/CS20191227

Published: 16 September 2020

...Joshua A. Beckman; Jiun-Ruey Hu; Shi Huang; Eric Farber-Eger; Quinn S. Wells; Thomas J. Wang; Robert E. Gerszten; Jane F. Ferguson Objective: Type 2 diabetes mellitus (T2DM) reduces exercise capacity, but the mechanisms are incompletely understood. We probed the impact of ischemic stress...

View articletitled, Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress

Includes: Supplementary data

Articles

TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy

Barbara Toffoli, Federica Tonon, Veronica Tisato, Andrea Michelli, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi

Clin Sci (Lond) (2020) 134 (17): 2337–2352.

https://doi.org/10.1042/CS20201004

Published: 10 September 2020

... studies have shown that TRAIL delivery ameliorated glucose control in type 1 and type 2 diabetes. It is currently unknown whether TRAIL positive effects are maintained in more severe forms of type 2 diabetes, and whether they include renoprotection. Our study aimed at evaluating TRAIL effects in a severe...

View articletitled, TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy

Includes: Supplementary data

Articles

Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang

Clin Sci (Lond) (2020) 134 (16): 2161–2175.

https://doi.org/10.1042/CS20200530

Published: 24 August 2020

... 2020 cognitive impairment hippocampus mitochondrial transplantation oxidative stress platelet type 2 diabetes The global convergence of lifestyle variation and population aging has resulted in the increased incidence of diabetes [ 1 ]. According to epidemiological analysis, the number...

View articletitled, Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Includes: Supplementary data

Articles

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

Jizheng Chen, Fang Wang, Yue Zhou, Jing Jiang, Sulaiman Ksimu, Xu Zhang, John Zhong Li, Junqi Niu, Qian Wang

Clin Sci (Lond) (2020) 134 (5): 529–542.

https://doi.org/10.1042/CS20190900

Published: 13 March 2020

...Jizheng Chen; Fang Wang; Yue Zhou; Jing Jiang; Sulaiman Ksimu; Xu Zhang; John Zhong Li; Junqi Niu; Qian Wang Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been...

View articletitled, Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

Includes: Supplementary data

Articles

Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Miroslava Kacířová, Anna Zmeškalová, Lucia Kořínková, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská

Clin Sci (Lond) (2020) 134 (5): 547–570.

https://doi.org/10.1042/CS20191313

Published: 13 March 2020

... play a role in inflammation. In this review, we try to elucidate the connections between peripheral inflammation at obesity and Type 2 diabetes and the central inflammatory process. Multiple lines of evidence highlight the importance of peripheral inflammation and its link to neuroinflammation, which...

View articletitled, Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

Articles

Adipokines as key players in β cell function and failure

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Nicolás Gómez-Banoy, James C. Lo

Clin Sci (Lond) (2019) 133 (22): 2317–2327.

https://doi.org/10.1042/CS20190523

Published: 26 November 2019

...Nicolás Gómez-Banoy; James C. Lo The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act...

View articletitled, Adipokines as key players in β cell function and failure

Articles

Specialized pro-resolving mediators in diabetes: novel therapeutic strategies

Eoin P. Brennan, Muthukumar Mohan, Darrell Andrews, Madhura Bose, Phillip Kantharidis

Clin Sci (Lond) (2019) 133 (21): 2121–2141.

https://doi.org/10.1042/CS20190067

Published: 06 November 2019

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes DKD is the leading cause of chronic kidney disease (CKD), leading to impaired renal function, scarring...

View articletitled, Specialized pro-resolving mediators in diabetes: novel therapeutic strategies

Articles

Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism

Ting Xie, Wing Yan So, Xing Yu Li, Po Sing Leung

Clin Sci (Lond) (2019) 133 (19): 2029–2044.

https://doi.org/10.1042/CS20190093

Published: 14 October 2019

... Press Limited on behalf of the Biochemical Society 2019 Apoptosis CVX343 Insulin Islets Obesity Type 2 diabetes Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and hyperlipidemia. Most patients with T2DM are overweight or obese, and thus...

View articletitled, Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism

Includes: Supplementary data

Articles

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

Mei Xue, Ting Li, Yue Wang, Yunpeng Chang, Ying Cheng, Yunhong Lu, Xiangyang Liu, Linxin Xu, Xiaoyu Li, Xiaochen Yu, Bei Sun, Liming Chen

Clin Sci (Lond) (2019) 133 (15): 1705–1720.

https://doi.org/10.1042/CS20190585

Published: 02 August 2019

...Mei Xue; Ting Li; Yue Wang; Yunpeng Chang; Ying Cheng; Yunhong Lu; Xiangyang Liu; Linxin Xu; Xiaoyu Li; Xiaochen Yu; Bei Sun; Liming Chen Cardiovascular complications contribute to the major mortality and morbidity in type 2 diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized...

View articletitled, Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

Includes: Supplementary data

Articles

Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons

Hiranya Pintana, Grazyna Lietzau, Ingrid Lovise Augestad, Fausto Chiazza, Thomas Nyström, Cesare Patrone, Vladimer Darsalia

Clin Sci (Lond) (2019) 133 (13): 1367–1386.

https://doi.org/10.1042/CS20190180

Published: 01 July 2019

...Hiranya Pintana; Grazyna Lietzau; Ingrid Lovise Augestad; Fausto Chiazza; Thomas Nyström; Cesare Patrone; Vladimer Darsalia Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes...

View articletitled, Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons

Includes: Supplementary data

Articles

Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Carlos Palma, Katherin Scholz-Romero, Omar Elfeky, Felipe Zuñiga, Valeska Ormazabal, Emilio Diaz, Gregory E. Rice, Gregory Duncombe, Thomas Jansson, Harold David McIntyre, Martha Lappas, Carlos Salomon

Clin Sci (Lond) (2018) 132 (22): 2451–2467.

https://doi.org/10.1042/CS20180487

Published: 30 November 2018

... Limited on behalf of the Biochemical Society 2018 exosomes Insulin sensitivity microRNA pregnancy type 2 diabetes Correspondence: Carlos Salomon ( [email protected] ) Human placentas at term (>37 weeks of gestation) were obtained from elective cesarean deliveries...

View articletitled, Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

Includes: Supplementary data

Articles

The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes

Sara Baqar, Dorothy Liu, Lisa F. Lincz, Yee Wen Kong, George Jerums, Elif I. Ekinci

Clin Sci (Lond) (2018) 132 (20): 2207–2220.

https://doi.org/10.1042/CS20180472

Published: 23 October 2018

...Sara Baqar; Dorothy Liu; Lisa F. Lincz; Yee Wen Kong; George Jerums; Elif I. Ekinci Objective: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin–angiotensin–aldosterone system (RAAS) activation...

View articletitled, The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes

Includes: Supplementary data

Articles

Cardiovascular benefits of GLP-1 agonists in type 2 diabetes: a comparative review

James G. Boyle, Rachel Livingstone, John R. Petrie

Clin Sci (Lond) (2018) 132 (15): 1699–1709.

https://doi.org/10.1042/CS20171299

Published: 16 August 2018

...James G. Boyle; Rachel Livingstone; John R. Petrie Type 2 diabetes (T2D) carries risks of both cardiovascular (CV) (myocardial infarction, stroke, and peripheral vascular disease) and microvascular (retinopathy/nephropathy/neuropathy) complications. Glucose-lowering is an effective strategy...

View articletitled, Cardiovascular benefits of GLP-1 agonists in type 2 diabetes: a comparative review

Articles

The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro

Patricia E. Martin, Erin M. O’Shaughnessy, Catherine S. Wright, Annette Graham

Clin Sci (Lond) (2018) 132 (15): 1629–1643.

https://doi.org/10.1042/CS20171483

Published: 14 August 2018

..., and the development of effective therapeutics for treatment of chronic wounds. Correspondence: Annette Graham ( [email protected] ) induced pluripotent stem cells type 2 diabetes Wound healing Diabetes mellitus is a major global health concern, affecting approximately 425 million adults...

View articletitled, The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro

Articles

Recent advances in the detection of brown adipose tissue in adult humans: a review

Frank J. Ong, Basma A. Ahmed, Stephan M. Oreskovich, Denis P. Blondin, Tahniyah Haq, Norman B. Konyer, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Katherine M. Morrison, Gregory R. Steinberg

Clin Sci (Lond) (2018) 132 (10): 1039–1054.

https://doi.org/10.1042/CS20170276

Published: 25 May 2018

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...

View articletitled, Recent advances in the detection of brown adipose tissue in adult humans: a review

Includes: Supplementary data

Articles

The role of renal dipeptidyl peptidase-4 in kidney disease: renal effects of dipeptidyl peptidase-4 inhibitors with a focus on linagliptin

Keizo Kanasaki

Clin Sci (Lond) (2018) 132 (4): 489–507.

https://doi.org/10.1042/CS20180031

Published: 28 February 2018

...Keizo Kanasaki Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors used to treat type 2 diabetes may have nephroprotective effects beyond the reduced renal risk conferred by glycemic control. DPP-4 is a ubiquitous protein with exopeptidase activity that exists in cell membrane...

View articletitled, The role of renal dipeptidyl peptidase-4 in kidney disease: renal effects of dipeptidyl peptidase-4 inhibitors with a focus on linagliptin

Articles

Functional blocking of Ninjurin1 as a strategy for protecting endothelial cells in diabetes mellitus

Xin Wang, Jinbao Qin, Xing Zhang, Zhiyou Peng, Kaichuang Ye, Xiaoyu Wu, Xinrui Yang, Huihua Shi, Zhen Zhao, Xin Guo, Xiaobing Liu, Minyi Yin, Xinwu Lu

Clin Sci (Lond) (2018) 132 (2): 213–229.

https://doi.org/10.1042/CS20171273

Published: 19 January 2018

... protein 1 (Ninj1) is an adhesion molecule that not only contributes to inflammation but also regulates the apoptosis of endothelial cells. In the present study, Ninj1 was found highly expressed in endothelial cells in Type 2 diabetic mice and increased in high-glucose (HG) cultured HUVECs. Furthermore, we...

View articletitled, Functional blocking of Ninjurin1 as a strategy for protecting endothelial cells in diabetes mellitus

Includes: Supplementary data

Articles

TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse

Stella Bernardi, Barbara Toffoli, Veronica Tisato, Fleur Bossi, Stefania Biffi, Andrea Lorenzon, Giorgio Zauli, Paola Secchiero, Bruno Fabris

Clin Sci (Lond) (2018) 132 (1): 69–83.

https://doi.org/10.1042/CS20171221

Published: 05 January 2018

... diabetes. It has been shown that TRAIL deficiency worsens diabetes and that TRAIL delivery, when it is given before disease onset, slows down its development. The present study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat type 2 diabetes. Thirty male C57BL/6J...

View articletitled, TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse

Includes: Supplementary data

Articles

Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Bram Brouwers, Vera B. Schrauwen-Hinderling, Tomas Jelenik, Anne Gemmink, Bas Havekes, Yvonne Bruls, Dennis Dahlmans, Michael Roden, Matthijs K.C. Hesselink, Patrick Schrauwen

Clin Sci (Lond) (2017) 131 (15): 1905–1917.

https://doi.org/10.1042/CS20170261

Published: 07 July 2017

...Bram Brouwers; Vera B. Schrauwen-Hinderling; Tomas Jelenik; Anne Gemmink; Bas Havekes; Yvonne Bruls; Dennis Dahlmans; Michael Roden; Matthijs K.C. Hesselink; Patrick Schrauwen Non-alcoholic fatty liver (NAFL) is an independent risk factor for the development of type 2 diabetes (T2DM). We examined...

View articletitled, Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Articles

Diabetes confers in vitro calcific potential on serum which associates with in vivo vascular calcification

Ashish Patidar, Dhruv K. Singh, Shori Thakur, Peter Winocour, Ken Farrington, Anwar R. Baydoun

Clin Sci (Lond) (2017) 131 (10): 991–1000.

https://doi.org/10.1042/CS20160882

Published: 09 May 2017

...Ashish Patidar; Dhruv K. Singh; Shori Thakur; Peter Winocour; Ken Farrington; Anwar R. Baydoun Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum...

View articletitled, Diabetes confers in vitro calcific potential on serum which associates with in vivo vascular calcification

Articles

GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction

Emilie Pastel, Laura J. McCulloch, Rebecca Ward, Shivam Joshi, Kim M. Gooding, Angela C. Shore, Katarina Kos

Clin Sci (Lond) (2017) 131 (5): 343–353.

https://doi.org/10.1042/CS20160803

Published: 15 February 2017

... AT that expresses the GLP-1 receptor (GLP-1R). The present study aimed to assess the impact of GLP-1 analogue treatment on subcutaneous AT (SCAT) inflammatory and fibrotic responses, compared with weight loss by calorie reduction (control). Among the 39 participants with Type 2 diabetes recruited, 30 age-matched...

View articletitled, GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction

Includes: Supplementary data

Articles

Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes

Rikke Kruse, Andreas J.T. Pedersen, Jonas M. Kristensen, Stine J. Petersson, Jørgen F.P. Wojtaszewski, Kurt Højlund

Clin Sci (Lond) (2017) 131 (1): 37–47.

https://doi.org/10.1042/CS20160736

Published: 09 December 2016

...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...

View articletitled, Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes

Includes: Supplementary data

Articles

Improvement of skin wound healing in diabetic mice by kinin B 2 receptor blockade

Dorinne Desposito, Catherine Chollet, Christopher Taveau, Vincent Descamps, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby, Ludovic Waeckel

Clin Sci (Lond) (2016) 130 (1): 45–56.

https://doi.org/10.1042/CS20150295

Published: 30 November 2015

... receptors kallikrein–kinin system skin wound healing Type 1 diabetes Type 2 diabetes • Impairment of skin wound repair is a major complication of diabetes, favouring development of foot ulcers and contributing to their poor prognosis. Improving skin healing is a therapeutic issue in diabetic...

View articletitled, Improvement of skin wound healing in diabetic mice by kinin B 2 receptor blockade

Articles

Short-term dietary salt supplementation blunts telmisartan induced increases in plasma renin activity in hypertensive patients with type 2 diabetes mellitus

Angela X. Chen, George Jerums, Sara Baqar, Elisabeth Lambert, Goji Somarajah, Georgina Thomas, Christopher O’Callaghan, Richard J. MacIsaac, Elif I. Ekinci

Clin Sci (Lond) (2015) 129 (5): 415–422.

https://doi.org/10.1042/CS20140536

Published: 11 June 2015

... aldosterone level and estimated glomerular filtration rate (eGFR) in hypertensive patients with type 2 diabetes. In a randomized, double-blind, placebo-controlled study (RCT), 28 patients with type 2 diabetes, treated with telmisartan (40 mg daily), received 2 weeks of placebo or NaCl capsules (100 mmol/24 h...

View articletitled, Short-term dietary salt supplementation blunts telmisartan induced increases in plasma renin activity in hypertensive patients with type 2 diabetes mellitus

Articles

Diurnal variation in skeletal muscle and liver glycogen in humans with normal health and Type 2 diabetes

Mavin Macauley, Fiona E Smith, Peter E Thelwall, Kieren G Hollingsworth, Roy Taylor

Clin Sci (Lond) (2015) 128 (10): 707–713.

https://doi.org/10.1042/CS20140681

Published: 27 February 2015

...Mavin Macauley; Fiona E Smith; Peter E Thelwall; Kieren G Hollingsworth; Roy Taylor Storage of food-derived glucose as muscle and liver glycogen is vital to avoid damaging swings plasma osmolarity. We report that in Type 2 diabetes, muscle glycogen storage was completely inactive although liver...

View articletitled, Diurnal variation in skeletal muscle and liver glycogen in humans with normal health and Type 2 diabetes

Articles

Normal weight individuals who develop Type 2 diabetes: the personal fat threshold

Roy Taylor, Rury R. Holman

Clin Sci (Lond) (2015) 128 (7): 405–410.

https://doi.org/10.1042/CS20140553

Published: 09 December 2014

...Roy Taylor; Rury R. Holman Type 2 diabetes (T2DM) is frequently regarded as a disease of obesity and its occurrence in individuals of normal body mass index (BMI) is often regarded as indicating a non-obesity-related subtype. However, the evidence for such a distinct, common subtype is lacking...

View articletitled, Normal weight individuals who develop Type 2 diabetes: the personal fat threshold

Articles

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways

Thiago Bruder-Nascimento, Glaucia E. Callera, Augusto C. Montezano, Ying He, Tayze T. Antunes, Aurelie Nguyen Dinh Cat, Rita C. Tostes, Rhian M. Touyz

Clin Sci (Lond) (2015) 128 (7): 411–423.

https://doi.org/10.1042/CS20140456

Published: 09 December 2014

... (db/db) mice, a model of Type 2 diabetes and control Lepr db /Lepr + (db/+) mice were administered atorvastatin (10 mg/kg per day, 2 weeks). Atorvastatin improved glucose tolerance in db/db mice. Systemic and vascular oxidative stress in db/db mice, characterized by increased plasma TBARS...

View articletitled, Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways

Includes: Supplementary data

Articles

NOD1 receptor is up-regulated in diabetic human and murine myocardium

Patricia Prieto, María Teresa Vallejo-Cremades, Gemma Benito, Pilar González-Peramato, Daniel Francés, Noelia Agra, Verónica Terrón, Silvia Gónzalez-Ramos, Carmen Delgado, Mariano Ruiz-Gayo, Ivette Pacheco, Juan P. Velasco-Martín, Javier Regadera, Paloma Martín-Sanz, Eduardo López-Collazo, Lisardo Boscá, María Fernández-Velasco

Clin Sci (Lond) (2014) 127 (12): 665–677.

https://doi.org/10.1042/CS20140180

Published: 08 August 2014

... Boscá; María Fernández-Velasco Type 2 diabetes has a complex pathology that involves a chronic inflammatory state. Emerging evidence suggests a link between the innate immune system receptor NOD1 (nucleotide-binding and oligomerization domain 1) and the pathogenesis of diabetes, in monocytes and hepatic...

View articletitled, NOD1 receptor is up-regulated in diabetic human and murine myocardium

Includes: Supplementary data

Articles

GdCl 3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice

Qian Wang, Ning Wang, Mei Dong, Fang Chen, Zhong Li, Yuanyuan Chen

Clin Sci (Lond) (2014) 127 (2): 91–100.

https://doi.org/10.1042/CS20130670

Published: 17 March 2014

... of the present study was to investigate the role of GdCl 3 in hepatic gluconeogenesis and explore the precise molecular mechanism. Animals from a classical Type 2 diabetic mouse model, created by exposing C57BL/6J mice to a high-fat diet for 4 months, were treated with GdCl 3 or saline. Body weight, blood...

View articletitled, GdCl 3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice

Articles

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme

Clin Sci (Lond) (2014) 126 (10): 739–752.

https://doi.org/10.1042/CS20130678

Published: 03 February 2014

.... In addition, we suggest that chronic eHSP72 exposure may mediate β-cell failure. aging extracellular heat-shock protein 72 (eHSP72) insulin resistance pancreatic β-cell Type 1 diabetes Type 2 diabetes Correspondence: Dr Mauricio Krause (email [email protected]...

View articletitled, Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Articles

Perturbations in skeletal muscle sarcomere structure in patients with heart failure and Type 2 diabetes: restorative effects of (−)-epicatechinrich cocoa

Pam R. Taub, Israel Ramirez-Sanchez, Theodore P. Ciaraldi, Silvia Gonzalez-Basurto, Ramon Coral-Vazquez, Guy Perkins, Michael Hogan, Alan S. Maisel, Robert R. Henry, Guillermo Ceballos, Francisco Villarreal

Clin Sci (Lond) (2013) 125 (8): 383–389.

https://doi.org/10.1042/CS20130023

Published: 14 June 2013

...Pam R. Taub; Israel Ramirez-Sanchez; Theodore P. Ciaraldi; Silvia Gonzalez-Basurto; Ramon Coral-Vazquez; Guy Perkins; Michael Hogan; Alan S. Maisel; Robert R. Henry; Guillermo Ceballos; Francisco Villarreal HF (heart failure) and T2D (Type 2 diabetes) associate with detrimental alterations in SkM...

View articletitled, Perturbations in skeletal muscle sarcomere structure in patients with heart failure and Type 2 diabetes: restorative effects of (−)-epicatechinrich cocoa

Articles

Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with Type 2 diabetes

Giovanni Targher, Alessandro Mantovani, Isabella Pichiri, Riccardo Rigolon, Marco Dauriz, Giacomo Zoppini, Giovanni Morani, Corrado Vassanelli, Enzo Bonora

Clin Sci (Lond) (2013) 125 (6): 301–310.

https://doi.org/10.1042/CS20130036

Published: 22 May 2013

... countries and share multiple risk factors. The relationship between NAFLD and AF in Type 2 diabetes is currently unknown. We studied a hospital-based sample of 702 patients with Type 2 diabetes discharged from our Division of Endocrinology during 2007–2011. The diagnosis of AF was confirmed in affected...

View articletitled, Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with Type 2 diabetes

Includes: Supplementary data

Articles

The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?

Karen E. Porter, Kirsten Riches

Clin Sci (Lond) (2013) 125 (4): 167–182.

https://doi.org/10.1042/CS20120413

Published: 26 April 2013

...Karen E. Porter; Kirsten Riches The rising epidemic of T2DM (Type 2 diabetes mellitus) worldwide is of significant concern. The inherently silent nature of the disease in its early stages precludes early detection; hence cardiovascular disease is often established by the time diabetes is diagnosed...

View articletitled, The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?

Articles

Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats

Tsuneo Kobayashi, Shingo Nemoto, Keiko Ishida, Kumiko Taguchi, Takayuki Matsumoto, Katsuo Kamata

Clin Sci (Lond) (2012) 123 (6): 375–386.

https://doi.org/10.1042/CS20110621

Published: 29 May 2012

... in their controls, but the total PP1α protein level was not different. These results suggest that the aortic relaxation responses, NO production, and eNOS activity mediated by CaMKII phosphorylation are decreased in this Type 2 diabetic model, and that these impairments of CaMKII signalling may be, at least in part...

View articletitled, Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats

Articles

Cellular and molecular mechanisms of metformin: an overview

Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli

Clin Sci (Lond) (2012) 122 (6): 253–270.

https://doi.org/10.1042/CS20110386

Published: 11 November 2011

...-line oral therapy for T2D (Type 2 diabetes). The main effect of this drug from the biguanide family is to acutely decrease hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory chain complex I. In addition, the resulting decrease in hepatic energy...

View articletitled, Cellular and molecular mechanisms of metformin: an overview

Articles

Toll-like receptors and diabetes: a therapeutic perspective

Mohan R. Dasu, Sandra Ramirez, Roslyn R. Isseroff

Clin Sci (Lond) (2012) 122 (5): 203–214.

https://doi.org/10.1042/CS20110357

Published: 28 October 2011

.... 12 7 2011 1 9 2011 8 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36...

View articletitled, Toll-like receptors and diabetes: a therapeutic perspective

Articles

Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates

Ee L. Lim, Kieren G. Hollingsworth, Fiona E. Smith, Peter E. Thelwall, Roy Taylor

Clin Sci (Lond) (2011) 121 (4): 169–177.

https://doi.org/10.1042/CS20100611

Published: 04 May 2011

..., but no direct measurement has tested this concept or its possible relationship to the reported impairment in insulin-stimulated muscle ATP production. Isoglycaemic–hyperinsulinaemic clamps with [ 13 C]glucose infusion were performed on Type 2 diabetic subjects and matched controls with measurement of glycogen...

View articletitled, Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates

Articles

Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes

Adriana Georgescu, Doina Popov, Anamaria Constantin, Miruna Nemecz, Nicoleta Alexandru, Daniel Cochior, Aura Tudor

Clin Sci (Lond) (2011) 120 (10): 463–472.

https://doi.org/10.1042/CS20100355

Published: 28 January 2011

...Adriana Georgescu; Doina Popov; Anamaria Constantin; Miruna Nemecz; Nicoleta Alexandru; Daniel Cochior; Aura Tudor The aim of the present study was to examine the effects of obesity alone and obesity associated with Type 2 diabetes on the structure, vascular reactivity and response to insulin...

View articletitled, Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes

Articles

The use of statins potentiates the insulin-sensitizing effect of exercise training in obese males with and without Type 2 diabetes

Ruth C. R. Meex, Esther Phielix, Vera B. Schrauwen-Hinderling, Esther Moonen-Kornips, Gert Schaart, Patrick Schrauwen, Matthijs K. C. Hesselink

Clin Sci (Lond) (2010) 119 (7): 293–301.

https://doi.org/10.1042/CS20100153

Published: 25 June 2010

.... cardiometabolic risk-factor exercise training insulin sensitivity mitochondrial function statin Type 2 diabetes Hyperlipidaemia and hyperglycaemia are frequently reported in obese subjects and are highly associated with the development of cardiovascular disorders, the primary cause of death...

View articletitled, The use of statins potentiates the insulin-sensitizing effect of exercise training in obese males with and without Type 2 diabetes

Includes: Supplementary data

Articles

Fenofibrate improves endothelial function in the brachial artery and forearm resistance arterioles of statin-treated Type 2 diabetic patients

Sandra J. Hamilton, Gerard T. Chew, Timothy M.E. Davis, Gerald F. Watts

Clin Sci (Lond) (2010) 118 (10): 607–615.

https://doi.org/10.1042/CS20090568

Published: 23 February 2010

...Sandra J. Hamilton; Gerard T. Chew; Timothy M.E. Davis; Gerald F. Watts Dyslipidaemia contributes to endothelial dysfunction and CVD (cardiovascular disease) in Type 2 diabetes mellitus. While statin therapy reduces CVD in these patients, residual risk remains high. Fenofibrate corrects atherogenic...

View articletitled, Fenofibrate improves endothelial function in the brachial artery and forearm resistance arterioles of statin-treated Type 2 diabetic patients

Articles

Effects of insulin resistance on endothelial progenitor cells and vascular repair

Richard M. Cubbon, Matthew B. Kahn, Stephen B. Wheatcroft

Clin Sci (Lond) (2009) 117 (5): 173–190.

https://doi.org/10.1042/CS20080263

Published: 03 August 2009

...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...

View articletitled, Effects of insulin resistance on endothelial progenitor cells and vascular repair

Articles

Diabetic cardiomyopathy

Omar Asghar, Ahmed Al-Sunni, Kaivan Khavandi, Ali Khavandi, Sarah Withers, Adam Greenstein, Anthony M. Heagerty, Rayaz A. Malik

Clin Sci (Lond) (2009) 116 (10): 741–760.

https://doi.org/10.1042/CS20080500

Published: 15 April 2009

... ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. diabetic cardiomyopathy heart failure hyperglycaemia Type 2 diabetes The link between HF (heart...

View articletitled, Diabetic cardiomyopathy

Articles

Cellular and physiological effects of C-peptide

Claire E. Hills, Nigel J. Brunskill

Clin Sci (Lond) (2009) 116 (7): 565–574.

https://doi.org/10.1042/CS20080441

Published: 02 March 2009

... in diabetes. C-peptide G-protein-coupled receptor proinsulin Type 1 diabetes Type 2 diabetes To exert hormone-like activity, C-peptide must have a receptor. Specific displaceable binding of C-peptide to pancreatic islet β-cells was initially described by Flatt et al. [ 6 ]. Ido and co...

View articletitled, Cellular and physiological effects of C-peptide

Articles

Obesity and diabetes: lipids, ‘nowhere to run to'

Margaret J. Hill, David Metcalfe, Philip G. McTernan

Clin Sci (Lond) (2009) 116 (2): 113–123.

https://doi.org/10.1042/CS20080050

Published: 15 December 2008

... understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors...

View articletitled, Obesity and diabetes: lipids, ‘nowhere to run to'

Articles

Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes

Wanzhu Jin, Mary-Elizabeth Patti

Clin Sci (Lond) (2009) 116 (2): 99–111.

https://doi.org/10.1042/CS20080090

Published: 15 December 2008

...Wanzhu Jin; Mary-Elizabeth Patti T2DM (Type 2 diabetes mellitus) has reached epidemic proportions worldwide, exerting major health consequences at an individual and public health level alike. Unfortunately, the molecular pathophysiology of diabetes remains incompletely understood, impairing...

View articletitled, Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes

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