... area in the total area of the tissue section was quantified in more than five fields for each mouse. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 ASK1 DUSP12 ischemia/reperfusion injury liver ubiquitination Hepatic ischemia...

...Jiangqiao Zhou; Tao Qiu; Tianyu Wang; Zhongbao Chen; Xiaoxiong Ma; Long Zhang; Jilin Zou Ubiquitin-specific peptidase 4 (USP4) protein is a type of deubiquitination enzyme that is correlated with many important biological processes. However, the function of USP4 in hepatic ischaemia/reperfusion (I...

... in modulating a vast expanse of physiological functions essential for maintenance of life. NRs display particular characteristics towards ubiquitination, the process of addition of specific ubiquitin tags at appropriate locations. Orchestrated through groups of enzymes harboring a diverse array of specialized...

...-2 is an ubiquitin ligase that catalyses the ubiquitination of proteins, resulting in proteasomal degradation. We hypothesized that inhibition of mechanistic target of rapamycin complex 1 (mTORC1) decreases amino acid uptake in primary human trophoblast (PHT) cells by activation of Nedd4-2, which...